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Christopher B. Burge

Christopher B. Burge

D-Index & Metrics

Genetics

D-Index
97
Citations
131131
World Ranking
820
National Ranking
411

Molecular Biology

D-Index
97
Citations
131131
World Ranking
580
National Ranking
319

Overview

Christopher B. Burge is affiliated with MIT in the United States and specializes in research within Biochemistry, Genetics, and Molecular Biology. Their work focuses extensively on Molecular Biology, with additional research interests spanning Genetics, Cellular and Molecular Neuroscience, Cardiology and Cardiovascular Medicine, and Psychiatry and Mental Health.

Their primary research topics include RNA Research and Splicing, RNA and protein synthesis mechanisms, RNA modifications and cancer, Genomics and Rare Diseases, Axon Guidance and Neuronal Signaling, Cancer, Stress, Anesthesia, and Immune Response, as well as Ion channel regulation and function.

Frequent co-authors with whom Burge has collaborated include Michael P. McGurk, Steven M. Blue, Louis Philip Benoit Bouvrette, Madeleine J. Oudin, and Scott D. Findlay.

Regular publication venues for their research consist of bioRxiv (Cold Spring Harbor Laboratory), ENCODE Datasets, Nature, Nature Communications, and Science Advances.

Recent notable papers authored or co-authored by Christopher B. Burge include:

  • Expanded encyclopaedias of DNA elements in the human and mouse genomes, 2020, Nature
  • A large-scale binding and functional map of human RNA-binding proteins, 2020, Nature
  • Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS, 2021, Molecular Cell
  • Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity, 2020, Nature Structural & Molecular Biology
  • Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3, 2022, npj Breast Cancer

Best Publications

  • Initial sequencing and analysis of the human genome.

    Eric S. Lander;Lauren M. Linton;Bruce Birren;Chad Nusbaum

  • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

    Benjamin P. Lewis;Christopher B. Burge;David P. Bartel

  • Most mammalian mRNAs are conserved targets of microRNAs

    Robin Carl Friedman;Kyle Kai-How Farh;Christopher B. Burge;David Bartel

  • Prediction of Complete Gene Structures in Human Genomic DNA

    Chris Burge;Samuel Karlin

  • Prediction of Mammalian MicroRNA Targets

    Benjamin P. Lewis;I-hung Shih;Matthew W. Jones-Rhoades;David P. Bartel

  • Alternative Isoform Regulation in Human Tissue Transcriptomes

    Eric T. Wang;Rickard Sandberg;Rickard Sandberg;Shujun Luo;Irina Khrebtukova

  • Prediction of Plant MicroRNA Targets

    Matthew W. Rhoades;Brenda J. Reinhart;Lee P. Lim;Christopher B. Burge

  • A uniform system for microRNA annotation

    Victor R. Ambros;Bonnie Bartel;David P. Bartel;Christopher B. Burge

  • Expanded encyclopaedias of DNA elements in the human and mouse genomes

    Jill E. Moore;Michael J. Purcaro;Henry E. Pratt;Charles B. Epstein

  • Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals.

    Gene W. Yeo;Christopher B. Burge

  • The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

    Kyle Kai-How Farh;Andrew Grimson;Calvin Jan;Benjamin P. Lewis

  • The microRNAs of Caenorhabditis elegans

    Lee P. Lim;Nelson C. Lau;Earl G. Weinstein;Aliaa Abdelhakim

  • Vertebrate microRNA genes.

    Lee P. Lim;Margaret E. Glasner;Soraya Yekta;Christopher B. Burge

  • Transcriptional Amplification in Tumor Cells with Elevated c-Myc

    Charles Y. Lin;Jakob Lovén;Peter B. Rahl;Ronald M. Paranal

  • Predictive Identification of Exonic Splicing Enhancers in Human Genes

    William G. Fairbrother;Ru-Fang Yeh;Phillip A. Sharp;Christopher B. Burge

  • Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

    Rickard Sandberg;Joel R. Neilson;Arup Sarma;Phillip A. Sharp

  • Analysis and design of RNA sequencing experiments for identifying isoform regulation

    Yarden Katz;Eric T Wang;Edoardo M Airoldi;Christopher B Burge

  • c-Myc regulates transcriptional pause release.

    Peter B. Rahl;Charles Y. Lin;Amy C. Seila;Ryan A. Flynn

  • Splicing regulation: from a parts list of regulatory elements to an integrated splicing code.

    Zefeng Wang;Christopher B. Burge

  • Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues

    Jason Merkin;Caitlin Russell;Ping Chen;Ping Chen;Christopher B. Burge

Frequent Co-Authors

Gene W. Yeo
Gene W. Yeo University of California, San Diego
Eric T. Wang
Eric T. Wang University of Florida
Brenton R. Graveley
Brenton R. Graveley University of Connecticut Health Center
Samuel Karlin
Samuel Karlin Stanford University
Edoardo M. Airoldi
Edoardo M. Airoldi Temple University
Noam Shomron
Noam Shomron Tel Aviv University
Karen Adelman
Karen Adelman Harvard University

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