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Frank B. Gertler

Frank B. Gertler

D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
33782
World Ranking
1532
National Ranking
861

Overview

Frank B. Gertler is affiliated with MIT in the United States and conducts research primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields, including Biotechnology, Cell Biology, Biomedical Engineering, Immunology and Allergy, and Cancer Research.

The main topics covered in Frank B. Gertler's research include Cancer Research and Treatments, Cellular Mechanics and Interactions, Nanoplatforms for Cancer Theranostics, Cell Adhesion Molecules Research, Cancer Genomics and Diagnostics, Molecular Biology Techniques and Applications, and Neurobiology and Insect Physiology Research.

Among recent publications, Frank B. Gertler has contributed to the following papers:

  • Microenvironment-triggered multimodal precision diagnostics, 2021, Nature Materials
  • Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function, 2020, Neural Development
  • Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila, 2021, UNC Libraries
  • The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance, 2020, UNC Libraries
  • Mena INV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis, 2020, UNC Libraries

Frequent coauthors who have collaborated with Frank B. Gertler include:

  • Julie Gates
  • David Van Vactor
  • Stephanie L. Gupton
  • Madeleine J. Oudin
  • Tatsiana Kosciuk

The most common publication venues for Frank B. Gertler's work are UNC Libraries, with seven publications, along with contributions to Nature Materials, Neural Development, and Cancer Research.

Best Publications

  • A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

    Douglas A Rubinson;Christopher P Dillon;Adam V Kwiatkowski;Claudia Sievers;Claudia Sievers

  • Cytoskeletal dynamics and transport in growth cone motility and axon guidance

    Erik W Dent;Frank B Gertler

  • Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility

    James E. Bear;Tatyana M. Svitkina;Matthias Krause;Dorothy A. Schafer

  • Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

    Jung-Hyun Min;Haifeng Yang;Mircea Ivan;Frank Gertler

  • Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

    Piers Nash;Xiaojing Tang;Stephen Orlicky;Qinghua Chen

  • Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

    Ioannis K. Zervantonakis;Shannon K. Hughes-Alford;Joseph L. Charest;John S. Condeelis

  • Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.

    Frank B Gertler;Kirsten Niebuhr;Matthias Reinhard;Jürgen Wehland

  • Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration.

    Matthias Krause;Erik W. Dent;James E. Bear;Joseph J. Loureiro

  • The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance

    Erik W. Dent;Stephanie L. Gupton;Frank B. Gertler

  • Negative Regulation of Fibroblast Motility by Ena/VASP Proteins

    James E Bear;Joseph J Loureiro;Irina Libova;Reinhard Fässler

  • The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids.

    Brian W. Howell;Lorene M. Lanier;Ronald Frank;Frank B. Gertler

  • Mena is required for neurulation and commissure formation.

    Lorene M Lanier;Monte A Gates;Walter Witke;A.Sheila Menzies

  • Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes.

    Valérie Laurent;Thomas P. Loisel;Birgit Harbeck;Ann Wehman

  • A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.

    Kirsten Niebuhr;Frank Ebel;Ronald Frank;Matthias Reinhard

  • Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end.

    Marisan R. Mejillano;Shin-ichiro Kojima;Derek Anthony Applewhite;Frank B. Gertler

  • An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

    Irina M. Shapiro;Albert W. Cheng;Nicholas C. Flytzanis;Michele Balsamo

  • RIAM, an Ena/VASP and Profilin Ligand, Interacts with Rap1-GTP and Mediates Rap1-Induced Adhesion

    Esther M. Lafuente;André A.F.L. van Puijenbroek;Matthias Krause;Christopher V. Carman

  • Mouse disabled (mDab1): a Src binding protein implicated in neuronal development

    Brian W. Howell;Frank B. Gertler;Jonathan A. Cooper

  • Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth

    Lawrence R. Zukerberg;Gentry N. Patrick;Margareta Nikolic;Sandrine Humbert

  • Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins.

    Melanie Barzik;Tatyana I. Kotova;Henry N. Higgs;Larnele Hazelwood

Frequent Co-Authors

John S. Condeelis
John S. Condeelis Albert Einstein College of Medicine
James E. Bear
James E. Bear University of North Carolina at Chapel Hill
Thomas E. Rohan
Thomas E. Rohan Albert Einstein College of Medicine
Jürgen Wehland
Jürgen Wehland Technische Universität Braunschweig
Alan Wells
Alan Wells University of Pittsburgh
Cornelia I. Bargmann
Cornelia I. Bargmann Rockefeller University
Marc Tessier-Lavigne
Marc Tessier-Lavigne Xaira Therapeutics

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