What is he best known for?
The fields of study he is best known for:
Cell biology, Ena/Vasp homology proteins, Actin, Filopodia and Actin cytoskeleton are his primary areas of study.
His research in Cell biology intersects with topics in Genetics, Lamellipodium and Profilin.
Frank B. Gertler has included themes like EVH1 domain, Vasodilator-stimulated phosphoprotein, Actin remodeling, ROR1 and MDia1 in his Ena/Vasp homology proteins study.
His work is dedicated to discovering how MDia1, Actin remodeling of neurons are connected with Commissure and other disciplines.
His Actin research integrates issues from Microtubule and Cytoskeleton.
His Motility research includes elements of Cancer research and Focal adhesion.
His most cited work include:
- A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference (1513 citations)
- Cytoskeletal dynamics and transport in growth cone motility and axon guidance (769 citations)
- Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility (719 citations)
What are the main themes of his work throughout his whole career to date?
Frank B. Gertler mainly investigates Cell biology, Actin, Ena/Vasp homology proteins, Metastasis and Actin cytoskeleton.
His study in Cell biology is interdisciplinary in nature, drawing from both Lamellipodium, Cytoskeleton and Profilin.
His studies in Actin integrate themes in fields like Axon guidance, Cell and Microtubule.
As part of the same scientific family, Frank B. Gertler usually focuses on Ena/Vasp homology proteins, concentrating on Actin remodeling and intersecting with Arp2/3 complex, MDia1 and Actin-binding protein.
His biological study spans a wide range of topics, including Tumor microenvironment, Cancer research, Breast cancer and Oncology.
His Actin cytoskeleton research incorporates elements of Integrin and Pleckstrin homology domain.
He most often published in these fields:
- Cell biology (64.19%)
- Actin (24.89%)
- Ena/Vasp homology proteins (20.52%)
What were the highlights of his more recent work (between 2014-2021)?
- Cell biology (64.19%)
- Metastasis (17.90%)
- Cancer research (16.16%)
In recent papers he was focusing on the following fields of study:
Frank B. Gertler focuses on Cell biology, Metastasis, Cancer research, Cancer and Actin.
His Cell biology study combines topics from a wide range of disciplines, such as RNA splicing and Gene expression.
The concepts of his Metastasis study are interwoven with issues in Tumor microenvironment, Tumor progression, Breast cancer and Oncology.
His Cancer research research includes themes of Haptotaxis, Fibronectin, Paclitaxel, Immunology and Signal transduction.
The study incorporates disciplines such as DNA, Cell, Cytoskeleton and Molecular biology in addition to Actin.
His study in the field of Actin cytoskeleton is also linked to topics like Fluorescence-lifetime imaging microscopy.
Between 2014 and 2021, his most popular works were:
- Distal Alternative Last Exons Localize mRNAs to Neural Projections. (132 citations)
- Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway (126 citations)
- Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance (103 citations)
In his most recent research, the most cited papers focused on:
His primary areas of study are Cell biology, Cancer research, Signal transduction, Metastasis and Actin.
His Cell biology study focuses on Phosphorylation in particular.
The Cancer research study combines topics in areas such as Gene silencing, Intravasation and Cortactin.
His Metastasis research is multidisciplinary, incorporating perspectives in Stage, Breast cancer and Proportional hazards model.
His Actin research is multidisciplinary, relying on both Axon, Anatomy, Slit and Nervous system.
His research integrates issues of Cancer cell, Actin cytoskeleton, Cytoskeleton, Mechanotransduction and Growth factor receptor in his study of Cell migration.
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