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Biology and Biochemistry
UK
2025

D-Index & Metrics

Immunology

D-Index
140
Citations
85001
World Ranking
163
National Ranking
15

Research.com Recognitions

  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Michael L. Dustin is affiliated with the University of Oxford in the United Kingdom. Their research focuses extensively on immunology, particularly within the realms of immune cell function, T-cell and B-cell immunology, and cancer immunotherapy. This work bridges immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology.

The main fields of study in Dustin's research output include:

  • Immunology and Microbiology
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these wide-ranging fields, specific subfields include:

  • Immunology
  • Oncology
  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging
  • Biophysics

The primary topics that Dustin investigates cover multiple aspects of immune function and therapy:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Monoclonal and Polyclonal Antibodies Research
  • Single-cell and spatial transcriptomics

Recent publications highlight contributions to the understanding of T-cell behavior and cancer therapies. Selected papers include:

  • "Promises and challenges of adoptive T-cell therapies for solid tumours," 2021, British Journal of Cancer
  • "Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells," 2020, Science
  • "An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory," 2022, Nature Cell Biology
  • "Cell-cell interfaces as specialized compartments directing cell function," 2020, Nature Reviews Molecular Cell Biology
  • "A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals," 2020, Nature Immunology

Dustin frequently collaborates with a core group of co-authors, indicating strong, ongoing research partnerships. These include Salvatore Valvo, Audun Kvalvaag, Ashwin Jainarayanan, Pablo F. Céspedes, and Omer Dushek.

The scientist's work has been published predominantly in a set of key journals and venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • American Journal Of Pathology
  • Biophysical Journal
  • Nature Immunology

Awards recognizing contributions to science include being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2009 and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • ATP mediates rapid microglial response to local brain injury in vivo

    Dimitrios Davalos;Jaime Grutzendler;Jaime Grutzendler;Guang Yang;Jiyun V Kim

  • The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

    Arash Grakoui;Shannon K. Bromley;Cenk Sumen;Mark M. Davis

  • Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

    Michael L. Dustin;Robert Rothlein;Atul K. Bhan;Charles A. Dinarello

  • T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

    Michael L. Dustin;Timothy A. Springer;Timothy A. Springer

  • A HUMAN INTERCELLULAR ADHESION MOLECULE (ICAM-1) DISTINCT FROM LFA-1

    Robert Rothlein;Michael L. Dustin;Steven D. Marlin;Timothy A. Springer

  • The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system.

    Timothy A. Springer;Michael L. Dustin;Takashi K. Kishimoto;Steven D. Marlin

  • Lymphocyte Function-associated Antigen-1 (LFA-1) Interaction with Intercellular Adhesion Molecule-1 (ICAM-1) is One of At Least Three Mechanisms for Lymphocyte Adhesion to Cultured Endothelial Cells

    Michael L. Dustin;Timothy A. Springer

  • Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.

    Gabriel D. Victora;Tanja A. Schwickert;David R. Fooksman;Alice O. Kamphorst

  • The immunological synapse.

    S K Bromley;W R Burack;K G Johnson;K Somersalo

  • Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

    Donald E. Staunton;Steven D. Marlin;Christian Stratowa;Michael L. Dustin

  • Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1.

    Donald E. Staunton;Michael L. Dustin;Timothy A. Springer

  • Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein

    Neng-Yao Shih;Jun Li;Vladimir Karpitskii;Ancho Nguyen

  • T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.

    Rajat Varma;Gabriele Campi;Tadashi Yokosuka;Takashi Saito

  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

    Donald E. Staunton;Michael L. Dustin;Harold P. Erickson;Timothy A. Springer

  • Visualizing dendritic cell networks in vivo.

    Randall L Lindquist;Guy Shakhar;Diana Dudziak;Hedda Wardemann

  • T Cell Receptor Signaling Precedes Immunological Synapse Formation

    Kyeong-Hee Lee;Amy D. Holdorf;Michael L. Dustin;Andrew C. Chan

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.

    Michael L Dustin;Michael W Olszowy;Amy D Holdorf;Jun Li

  • The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

    Michael L. Dustin;John A. Cooper

  • The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

    Wei Tang;Yi Lu;Yi Lu;Qing-Yun Tian;Yan Zhang

  • Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

    Tadashi Yokosuka;Kumiko Sakata-Sogawa;Wakana Kobayashi;Michio Hiroshima

Frequent Co-Authors

Timothy A. Springer
Timothy A. Springer Boston Children's Hospital
Robert Rothlein
Robert Rothlein Boehringer Ingelheim (Germany)
Donald E. Staunton
Donald E. Staunton CisThera (United States)
Michel C. Nussenzweig
Michel C. Nussenzweig Rockefeller University
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
Jay T. Groves
Jay T. Groves University of California, Berkeley
Simon J. Davis
Simon J. Davis University of Oxford
Michael P. Sheetz
Michael P. Sheetz The University of Texas Medical Branch at Galveston
Mark R. Middleton
Mark R. Middleton University of Oxford

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