His primary areas of study are Biophysics, Cell adhesion, Catch bond, Cell biology and Ligand. The concepts of his Biophysics study are interwoven with issues in Selectin, Plasma protein binding, Stereochemistry and Immunology. The Cell adhesion study combines topics in areas such as Kinetics, Receptor, Integrin and Cell adhesion molecule.
He works mostly in the field of Integrin, limiting it down to concerns involving Cytoskeleton and, occasionally, Mechanotransduction, Clutch, Signal transducing adaptor protein and Rigidity. The various areas that Cheng Zhu examines in his Catch bond study include Leukocyte Rolling, Molecular dynamics, Hinge, Protein structure and Slip. Cheng Zhu interconnects Synapse, Synapse formation, Neuroscience and Antigen receptor in the investigation of issues within Cell biology.
Biophysics, Cell biology, Integrin, Cell adhesion and Receptor are his primary areas of study. His Biophysics study combines topics in areas such as Adhesion, Selectin, Plasma protein binding, Biochemistry and Kinetics. His Cell biology research incorporates themes from Cytoskeleton and T-cell receptor.
His work deals with themes such as Ligand, Platelet, Intercellular Adhesion Molecule-1, Extracellular matrix and Biological membrane, which intersect with Integrin. His work in Cell adhesion is not limited to one particular discipline; it also encompasses Cell adhesion molecule. His biological study spans a wide range of topics, including Cell, Antibody and Molecular biology.
His main research concerns Biophysics, Composite material, Cracking, Geotechnical engineering and Mechanotransduction. His Biophysics research is multidisciplinary, relying on both Integrin, Cytoskeleton, Actin, Binding site and Biological membrane. His studies deal with areas such as Signal transduction and Function as well as Mechanotransduction.
His research integrates issues of Cell surface receptor, Cell and Cell adhesion in his study of Signal transduction. His study in Cell adhesion is interdisciplinary in nature, drawing from both Effector and Receptor Cross-Talk. His Cell biology study incorporates themes from Innate immune system, Ligand and Glycosphingolipid.
His primary scientific interests are in Signal transduction, Cracking, Cell biology, Biophysics and Function. Cheng Zhu interconnects Integrin, Cell adhesion, Affinity maturation and Biological membrane in the investigation of issues within Signal transduction. His Cell adhesion research includes themes of Effector, Neuroscience and Receptor Cross-Talk.
His research integrates issues of Crystallite, Optics and Deformation in his study of Cracking. His studies deal with areas such as T cell, Immune system and Antigen as well as Cell biology. The various areas that Cheng Zhu examines in his Biophysics study include Acquired immune system, Cell surface receptor and Antigen recognition.
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Direct observation of catch bonds involving cell-adhesion molecules
Bryan T. Marshall;Mian Long;Mian Long;James W. Piper;Tadayuki Yago.
Demonstration of catch bonds between an integrin and its ligand
Fang Kong;Andrés J. García;A. Paul Mould;Martin J. Humphries.
Journal of Cell Biology (2009)
Cell mechanics: mechanical response, cell adhesion, and molecular deformation.
Cheng Zhu;Gang Bao;Ning Wang.
Annual Review of Biomedical Engineering (2000)
Measuring two-dimensional receptor-ligand binding kinetics by micropipette.
Scott E. Chesla;Periasamy Selvaraj;Cheng Zhu.
Biophysical Journal (1998)
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
Jun Huang;Veronika I. Zarnitsyna;Baoyu Liu;Lindsay J. Edwards.
Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity
Alberto Elosegui-Artola;Roger Oria;Yunfeng Chen;Yunfeng Chen;Anita Kosmalska.
Nature Cell Biology (2016)
Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling
Baoyu Liu;Wei Chen;Brian D. Evavold;Cheng Zhu.
Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond
Evan Evans;Andrew Leung;Volkmar Heinrich;Cheng Zhu.
Proceedings of the National Academy of Sciences of the United States of America (2004)
Rolling cell adhesion.
Rodger P. McEver;Cheng Zhu.
Annual Review of Cell and Developmental Biology (2010)
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.
Swapan K. Nath;Shizhong Han;Xana Kim-Howard;Jennifer A. Kelly.
Nature Genetics (2008)
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