World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
19769
World Ranking
4818
National Ranking
2323

Overview

Cheng Zhu is affiliated with the Georgia Institute of Technology in the United States. Their research primarily spans the fields of Medicine, and Biochemistry, Genetics and Molecular Biology.

The scientist's work is focused on several subfields including Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, Cell Biology, and Atomic and Molecular Physics, and Optics. The main topics covered in their research include Monoclonal and Polyclonal Antibodies Research, T-cell and B-cell Immunology, Cellular Mechanics and Interactions, Cell Adhesion Molecules Research, Force Microscopy Techniques and Applications, Immunotherapy and Immune Responses, and CAR-T cell therapy research.

Cheng Zhu has published numerous articles in various scientific venues. The more frequent publication venues for their work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • APL Bioengineering
  • Journal of Physics Conference Series
  • Biophysical Journal

Their recent papers include:

  • PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition, 2021, Nature Communications
  • Catch bond models may explain how force amplifies TCR signaling and antigen discrimination, 2023, Nature Communications
  • Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity, 2022, Nature Communications
  • Signaling mechanisms of the platelet glycoprotein Ib-IX complex, 2022, Platelets
  • Mechanotransduction in T Cell Development, Differentiation and Function, 2020, Cells

Cheng Zhu has collaborated frequently with several coauthors, including:

  • Kaitao Li
  • Zhou Yuan
  • Hyun-Kyu Choi
  • Stefano Travaglino
  • Muaz Nik Rushdi

Best Publications

  • Direct observation of catch bonds involving cell-adhesion molecules

    Bryan T. Marshall;Mian Long;Mian Long;James W. Piper;Tadayuki Yago

  • Demonstration of catch bonds between an integrin and its ligand

    Fang Kong;Andrés J. García;A. Paul Mould;Martin J. Humphries

  • Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

    Alberto Elosegui-Artola;Roger Oria;Yunfeng Chen;Yunfeng Chen;Anita Kosmalska

  • Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

    Baoyu Liu;Wei Chen;Brian D. Evavold;Cheng Zhu

  • The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

    Jun Huang;Veronika I. Zarnitsyna;Baoyu Liu;Lindsay J. Edwards

  • Cell mechanics: mechanical response, cell adhesion, and molecular deformation.

    Cheng Zhu;Gang Bao;Ning Wang

  • Measuring two-dimensional receptor-ligand binding kinetics by micropipette.

    Scott E. Chesla;Periasamy Selvaraj;Cheng Zhu

  • Rolling cell adhesion.

    Rodger P. McEver;Cheng Zhu

  • Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond

    Evan Evans;Andrew Leung;Volkmar Heinrich;Cheng Zhu

  • A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

    Swapan K. Nath;Shizhong Han;Xana Kim-Howard;Jennifer A. Kelly

  • Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF

    Tadayuki Yago;Jizhong Lou;Tao Wu;Jun Yang

  • Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.

    Vincent C. Luca;Vincent C. Luca;Byoung Choul Kim;Byoung Choul Kim;Chenghao Ge;Shinako Kakuda

  • DNA-based digital tension probes reveal integrin forces during early cell adhesion

    Yun Zhang;Chenghao Ge;Cheng Zhu;Khalid Salaita

  • Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan.

    Krishna K. Sarangapani;Tadayuki Yago;Arkadiusz G. Klopocki;Michael B. Lawrence

  • T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

    Jarrett J. Adams;Samanthi Narayanan;Baoyu Liu;Michael E. Birnbaum

  • Catch bonds govern adhesion through L-selectin at threshold shear.

    Tadayuki Yago;Jianhua Wu;C. Diana Wey;Arkadiusz G. Klopocki

  • Kinetics and mechanics of cell adhesion.

    Cheng Zhu

  • Receptor-mediated cell mechanosensing.

    Yunfeng Chen;Yunfeng Chen;Lining Ju;Muaz Rushdi;Muaz Rushdi;Chenghao Ge;Chenghao Ge

  • Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

    Wei Chen;Jizhong Lou;Jizhong Lou;Cheng Zhu

  • Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

    David Cole;Anna Marta Bulek;Garry Michael Dolton;Andrea J. Schauenberg

Frequent Co-Authors

Rodger P. McEver
Rodger P. McEver Oklahoma Medical Research Foundation
Brian D. Evavold
Brian D. Evavold University of Utah
Chao-Sheng Tang
Chao-Sheng Tang Nanjing University
Bin Shi
Bin Shi Nanjing University
Shaun P. Jackson
Shaun P. Jackson University of Sydney
John Freedman
John Freedman University of Toronto
Heyu Ni
Heyu Ni University of Toronto
Michael L. Dustin
Michael L. Dustin University of Oxford
Andrés J. García
Andrés J. García Georgia Institute of Technology
Tanya N. Mayadas
Tanya N. Mayadas Brigham and Women's Hospital

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