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Immunology

D-Index
80
Citations
20454
World Ranking
1645
National Ranking
141

Overview

Andrew K. Sewell is affiliated with Cardiff University in the United Kingdom. Their research primarily spans the fields of Immunology and Microbiology, with significant contributions also in Medicine. Sewell's work delves into various subfields including Immunology, Epidemiology, Oncology, Molecular Biology, and Infectious Diseases.

The scientist's main research topics encompass:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Influenza Virus Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • Vaccines and immunoinformatics approaches

Sewell has published several papers between 2020 and 2023 in prominent journals. Recent papers include:

  • "Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1" (2020, Nature Immunology)
  • "VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2" (2022, Nature Methods)
  • "Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy" (2023, Cell)
  • "Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope" (2022, Cell)
  • "Simultaneous Aerosol and Intramuscular Immunization with Influenza Vaccine Induces Powerful Protective Local T Cell and Systemic Antibody Immune Responses in Pigs" (2020, The Journal of Immunology)

Among frequent coauthors collaborating with Sewell are Garry Dolton, Anna Fuller, Cristina Rius, Barbara Szomolay, and Théo Morin.

The scientist's work is regularly published in several venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Nature Immunology
  • Cell
  • Cell Reports

Best Publications

  • POSITIVE SELECTION OF HIV-1 CYTOTOXIC T LYMPHOCYTE ESCAPE VARIANTS DURING PRIMARY INFECTION

    David A. Price;Philip J. R. Goulder;Paul Klenerman;Andrew K. Sewell

  • Monoclonal TCR-redirected tumor cell killing

    Nathaniel Liddy;Giovanna Bossi;Katherine J. Adams;Anna Lissina

  • VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

    Mikhail Shugay;Dmitriy V Bagaev;Ivan V Zvyagin;Renske M Vroomans

  • Why must T cells be cross-reactive?

    Andrew K. Sewell

  • A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

    Linda Wooldridge;Julia Ekeruche-Makinde;Hugo A. van den Berg;Anna Skowera;Anna Skowera

  • Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes

    Annette Oxenius;David A. Price;Philippa J. Easterbrook;Christopher A. O'Callaghan

  • Avidity for antigen shapes clonal dominance in CD8 + T cell populations specific for persistent DNA viruses

    David A. Price;Jason M. Brenchley;Laura E. Ruff;Michael R. Betts

  • CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

    Ania Skowera;Richard J. Ellis;Ruben Varela-Calviño;Sefina Arif

  • VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium

    Dmitry V Bagaev;Renske M A Vroomans;Jerome Samir;Jerome Samir;Ulrik Stervbo;Ulrik Stervbo

  • The Bisphosphonate Acute Phase Response: Rapid and Copious Production of Proinflammatory Cytokines by Peripheral Blood Gd T Cells in Response to Aminobisphosphonates Is Inhibited by Statins

    R. E. Hewitt;A. Lissina;A. E. Green;E. S. Slay

  • Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines

    Ji-Li Chen;Guillaume Stewart-Jones;Giovanna Bossi;Nikolai M. Lissin

  • Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

    Angel Varela-Rohena;Peter E. Molloy;Steven M. Dunn;Yi Li

  • Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA

    Alasdair Leslie;Daniel Kavanagh;Isobella Honeyborne;Katja Pfafferott

  • Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

    Bruno Frederic Laugel;Hugo A. van den Berg;Emma Gostick;David Cole

  • Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation

    P.J.R. Goulder;A.K. Sewell;D.G. Lalloo;David Price

  • Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies

    Paul M Maciocia;Patrycja A Wawrzyniecka;Brian Philip;Ida Ricciardelli

  • Human TCR-binding affinity is governed by MHC class restriction.

    David K. Cole;Nicholas J. Pumphrey;Jonathan M. Boulter;Malkit Sami

  • T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.

    Oleg Y. Borbulevych;Kurt H. Piepenbrink;Brian E. Gloor;Daniel R. Scott

  • CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells

    Mateusz Legut;Garry Dolton;Afsar Ali Mian;Oliver G. Ottmann

  • Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

    Michael D. Crowther;Garry Dolton;Mateusz Legut;Marine E. Caillaud

  • Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

    David Cole;Anna Marta Bulek;Garry Michael Dolton;Andrea J. Schauenberg

Frequent Co-Authors

David Price
David Price University of Aberdeen
John J. Miles
John J. Miles James Cook University
Bent K. Jakobsen
Bent K. Jakobsen Continuum Life Sciences
Mark Peakman
Mark Peakman King's College London
Rodney E. Phillips
Rodney E. Phillips University of Oxford
Emma Gostick
Emma Gostick Cardiff University
Andrew James Godkin
Andrew James Godkin Cardiff University
Kristin Ladell
Kristin Ladell Cardiff University
Jamie Rossjohn
Jamie Rossjohn Monash University
Philip J. R. Goulder
Philip J. R. Goulder University of Oxford

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