2001 - Fellow of Alfred P. Sloan Foundation
J. Troy Littleton spends much of his time researching Cell biology, Neurotransmitter, Neurotransmission, Vesicle fusion and Synaptotagmin 1. He combines Cell biology and Dorsal closure in his studies. He usually deals with Neurotransmitter and limits it to topics linked to Neuroscience and Receptor, VAMP2 and Complexin.
His study looks at the intersection of Neurotransmission and topics like Synaptic vesicle with Postsynaptic potential. His Synaptotagmin 1 research focuses on Synaptotagmin I and how it relates to Biochemistry and Synaptotagmins. His studies deal with areas such as SNAPAP and SNARE complex as well as STX1A.
His primary areas of investigation include Cell biology, Synaptic vesicle, Synaptotagmin 1, Neuroscience and Vesicle fusion. His Cell biology research includes elements of STX1A, Postsynaptic potential, Neurotransmitter, Neurotransmission and Complexin. His studies in Synaptic vesicle integrate themes in fields like Synapse, SNARE complex, Lipid bilayer fusion and Syntaxin.
His Synaptotagmin 1 research incorporates themes from Synaptic vesicle exocytosis, Synaptic augmentation, Synaptotagmin I and Synaptotagmins. His studies deal with areas such as Synaptic plasticity and Endocytosis as well as Neuroscience. His Vesicle fusion research includes themes of SNAP25, SNARE binding, Cooperativity and Kiss-and-run fusion.
His scientific interests lie mostly in Neuroscience, Cell biology, Synaptic plasticity, Postsynaptic potential and Synaptotagmin 1. The Neuroscience study combines topics in areas such as Active zone, Endocytosis, Gene knockdown and Endosome. His Cell biology study incorporates themes from Cortex and Drosophila.
He interconnects Tonic, Neurotransmission, Neurotransmitter and Neuron in the investigation of issues within Synaptic plasticity. His Neurotransmission study combines topics from a wide range of disciplines, such as Neuromuscular junction and Interneuron. His Synaptotagmin 1 study introduces a deeper knowledge of Synaptic vesicle.
J. Troy Littleton mainly focuses on Neuroscience, Synaptic plasticity, Cell biology, Neurotransmitter and Synapse. His Neuroscience research is multidisciplinary, incorporating elements of Internalization, Endocytosis, Endosome and Calcium signaling. The concepts of his Synaptic plasticity study are interwoven with issues in Active zone, Tonic, Postsynaptic potential and Neuron.
His research integrates issues of Glutamatergic, Homeostatic plasticity, Premovement neuronal activity, Neuronal circuits and Neuroplasticity in his study of Postsynaptic potential. His Cell biology research is multidisciplinary, relying on both SYT7, Drosophila and Synaptotagmin 1. His Neurotransmitter study integrates concerns from other disciplines, such as Motor neuron, Synaptic vesicle and Calcium imaging.
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Comparative Genomics of the Eukaryotes
Gerald M. Rubin;Mark D. Yandell;Jennifer R. Wortman;George L. Gabor.
Insights into social insects from the genome of the honeybee Apis mellifera
George M. Weinstock;Gene E. Robinson;Richard A. Gibbs;Kim C. Worley.
Ion channels and synaptic organization: analysis of the Drosophila genome.
J.Troy Littleton;J.Troy Littleton;Barry Ganetzky.
Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release
J.Troy Littleton;Michael Stern;Karen Schulze;Mark Perin.
A Drosophila Neurexin Is Required for Septate Junction and Blood-Nerve Barrier Formation and Function
Stefan Baumgartner;J.Troy Littleton;Kendal Broadie;Manzoor A Bhat.
Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.
Wyan-Ching Mimi Lee;Motojiro Yoshihara;J. Troy Littleton.
Proceedings of the National Academy of Sciences of the United States of America (2004)
Synaptotagmin I Functions as a Calcium Sensor to Synchronize Neurotransmitter Release
Motojiro Yoshihara;J.Troy Littleton.
Temperature-Sensitive Paralytic Mutations Demonstrate that Synaptic Exocytosis Requires SNARE Complex Assembly and Disassembly
J.Troy Littleton;Edwin R Chapman;Robert Kreber;Martin B Garment.
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth.
Sarah Huntwork;J Troy Littleton.
Nature Neuroscience (2007)
ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner.
Mark N. Wu;J. Troy Littleton;Manzoor A. Bhat;Andreas Prokop.
The EMBO Journal (1998)
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