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Biology and Biochemistry

D-Index
96
Citations
34237
World Ranking
1820
National Ranking
1004

Overview

Josep Rizo is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with significant contributions in Molecular Biology, Cell Biology, Physiology, Cellular and Molecular Neuroscience, and Genetics.

The research topics covered by Rizo include:

  • Cellular transport and secretion
  • Lipid Membrane Structure and Behavior
  • Erythrocyte Function and Pathophysiology
  • Calcium signaling and nucleotide metabolism
  • RNA and protein synthesis mechanisms
  • Retinal Development and Disorders
  • Neuroscience and Neuropharmacology Research

Rizo has published extensively, with frequent appearances in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • FEBS Open Bio
  • eLife
  • Science Advances

Recent publications include:

  • "Computed structures of core eukaryotic protein complexes," 2021, Science
  • "Molecular Mechanisms Underlying Neurotransmitter Release," 2022, Annual Review of Biophysics
  • "SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex," 2022, Science Advances
  • "Ca2+-dependent release of synaptotagmin-1 from the SNARE complex on phosphatidylinositol 4,5-bisphosphate-containing membranes," 2020, eLife
  • "A partially disordered region connects gene repression and activation functions of EZH2," 2020, Proceedings of the National Academy of Sciences

Frequent co-authors collaborating with Rizo include:

  • Klaudia Jaczynska
  • Karolina P. Stepien
  • Junjie Xu
  • Christian Rosenmund
  • Levent Sari

Best Publications

  • Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor

    Laura B Sheard;Xu-Hui Tan;Haibin Mao;John Withers

  • Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

    Huayi Wang;Liming Sun;Lijing Su;Josep Rizo

  • Synaptotagmin I functions as a calcium regulator of release probability

    Rafael Fernández-Chacón;Andreas Königstorfer;Stefan H. Gerber;Jesús García

  • C2-DOMAINS, STRUCTURE AND FUNCTION OF A UNIVERSAL CA2+-BINDING DOMAIN

    Josep Rizo;Thomas C. Südhof

  • A conformational switch in syntaxin during exocytosis: role of munc18

    Irina Dulubova;Shuzo Sugita;Sandra Hill;Masahiro Hosaka

  • RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

    Pascal S. Kaeser;Pascal S. Kaeser;Lunbin Deng;Lunbin Deng;Yun Wang;Irina Dulubova

  • Snares and Munc18 in synaptic vesicle fusion.

    Josep Rizo;Thomas C. Südhof

  • A Broken α-Helix in Folded α-Synuclein

    Sreeganga Chandra;Xiaocheng Chen;Josep Rizo;Reinhard Jahn

  • Synaptic vesicle fusion

    Josep Rizo;Christian Rosenmund

  • Synaptic Vesicle Exocytosis

    Thomas C. Südhof;Josep Rizo

  • Constrained peptides: models of bioactive peptides and protein substructures.

    Josep Rizo;Lila M. Gierasch

  • A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis

    Jiong Tang;Anton Maximov;Ok Ho Shin;Han Dai

  • Synaptotagmins: C2-Domain Proteins That Regulate Membrane Traffic

    Thomas C Südhof;Josep Rizo

  • Three-dimensional structure of the complexin/SNARE complex.

    Xiaocheng Chen;Diana R. Tomchick;Evguenii Kovrigin;Demet Araç

  • Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.

    Imma Fernandez;Demet Araç;Josep Ubach;Stefan H. Gerber

  • The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?

    Josep Rizo;Thomas C. Südhof

  • Bipartite Ca2+-Binding Motif in C2 Domains of Synaptotagmin and Protein Kinase C

    Xuguang Shao;Bazbek A. Davletov;R. Bryan Sutton;Thomas C. Südhof

  • Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2‐domain?

    Josep Ubach;Xiangyang Zhang;Xuguang Shao;Thomas C. Südhof

  • Computed structures of core eukaryotic protein complexes.

    Ian R. Humphreys;Jimin Pei;Minkyung Baek;Aditya Krishnakumar

  • Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex.

    Cong Ma;Wei Li;Yibin Xu;Josep Rizo

Frequent Co-Authors

Thomas C. Südhof
Thomas C. Südhof Stanford University
Christian Rosenmund
Christian Rosenmund Charité - University Medicine Berlin
Diana R. Tomchick
Diana R. Tomchick The University of Texas Southwestern Medical Center
Lila M. Gierasch
Lila M. Gierasch University of Massachusetts Amherst
Mischa Machius
Mischa Machius The University of Texas Southwestern Medical Center
Jun Lu
Jun Lu Zhejiang University
Jean Rivier
Jean Rivier Salk Institute for Biological Studies
Hongtao Yu
Hongtao Yu The University of Texas Southwestern Medical Center
Reinhard Jahn
Reinhard Jahn Max Planck Society
Ernest Giralt
Ernest Giralt University of Barcelona

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