World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
78
Citations
22666
World Ranking
3781
National Ranking
1205

Biology and Biochemistry

D-Index
78
Citations
22859
World Ranking
4528
National Ranking
2203

Research.com Recognitions

  • 2019 - Member of the National Academy of Sciences
  • 2016 - Fellow of the American Academy of Arts and Sciences
  • 2006 - Garvan–Olin Medal, American Chemical Society (ACS)
  • 2006 - National Institutes of Health Director's Pioneer Award
  • 1989 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1986 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1984 - Fellow of Alfred P. Sloan Foundation

Overview

Lila M. Gierasch is affiliated with the University of Massachusetts Amherst in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions to molecular biology, information systems and management, cell biology, materials chemistry, and information systems.

The scientist has published extensively on topics including:

  • Heat shock proteins research
  • Protein structure and dynamics
  • Endoplasmic reticulum stress and disease
  • Enzyme structure and function
  • Academic publishing and open access
  • Scientific computing and data management
  • Research data management practices

Their recent notable papers include:

  • "The Proteome Folding Problem and Cellular Proteostasis," 2021, Journal of Molecular Biology
  • "How the Protein Data Bank changed biology: An introduction to the JBC Reviews thematic series, part 1," 2021, Journal of Biological Chemistry
  • "Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein," 2021, Proceedings of the National Academy of Sciences
  • "ER chaperones use a protein folding and quality control glyco-code," 2023, Molecular Cell
  • "Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones," 2021, PLoS Computational Biology

Frequent co-authors in Gierasch's work include George Demartino, Joseph M. Jez, Mark J. Banfield, Donald Blumenthal, and F. Peter Guengerich.

Publications are often found in several key venues, particularly the Journal of Biological Chemistry, in which they have 56 publications. Other frequent venues include The FASEB Journal, Proceedings of the National Academy of Sciences, bioRxiv (Cold Spring Harbor Laboratory), and the Journal of Lipid Research.

Lila M. Gierasch has received several awards throughout their career, such as:

  • Member of the National Academy of Sciences (2019)
  • Fellow of the American Academy of Arts and Sciences (2016)
  • Garvan-Olin Medal, American Chemical Society (ACS) (2006)
  • National Institutes of Health Director's Pioneer Award (2006)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1989)
  • Fellow of John Simon Guggenheim Memorial Foundation (1986)
  • Fellow of Alfred P. Sloan Foundation (1984)

Best Publications

  • Turns in peptides and proteins.

    Rose Gd;Gierasch Lm;Smith Ja

  • Sending signals dynamically.

    Robert G. Smock;Lila M. Gierasch

  • Constrained peptides: models of bioactive peptides and protein substructures.

    Josep Rizo;Lila M. Gierasch

  • The crystal structure of the GroES co-chaperonin at 2.8 Å resolution

    John F. Hunt;Arthur J. Weaver;Samuel J. Landry;Samuel J. Landry;Lila Gierasch;Lila Gierasch

  • Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).

    Francois Xavier Theillet;Andres Binolfi;Tamara Frembgen-Kesner;Karan Hingorani

  • Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

    Yuval Reiss;Sarah J. Stradley;Lila M. Gierasch;Michael S. Brown

  • Different conformations for the same polypeptide bound to chaperones DnaK and GroEL.

    Samuel J. Landry;Robert Jordan;Roger McMacken;Lila M. Gierasch

  • Hsp70 Chaperone Ligands Control Domain Association via an Allosteric Mechanism Mediated by the Interdomain Linker

    Joanna F. Swain;Gizem Dinler;Renuka Sivendran;Diana L. Montgomery

  • Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant.

    Zoya Ignatova;Lila M. Gierasch

  • The changing landscape of protein allostery.

    Joanna F Swain;Lila M Gierasch

  • How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

    Eugenia M. Clerico;Joseph M. Tilitsky;Wenli Meng;Lila M. Gierasch

  • Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase.

    Joseph L. Goldstein;Michael S. Brown;Sarah J. Stradley;Yuval Reiss

  • The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation.

    Anu Bansal;Lila M. Gierasch

  • Roles of β-Turns in Protein Folding: From Peptide Models to Protein Engineering

    Anna Marie C. Marcelino;Lila M. Gierasch

  • An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

    Anastasia Zhuravleva;Eugenia M. Clerico;Lila M. Gierasch

  • Molecular Mechanisms of Protein Secretion: The Role of the Signal Sequence

    Martha S. Briggs;Lila M. Gierasch

  • Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling

    Zoya Ignatova;Lila M. Gierasch

  • Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones.

    Matthias P. Mayer;Lila M. Gierasch

  • Characterization of a functionally important mobile domain of GroES

    Samuel J. Landry;Jill Zeilstra-Ryalls;Jill Zeilstra-Ryalls;Olivier Fayet;Olivier Fayet;Costa Georgopoulos;Costa Georgopoulos

  • Conformations of (X-L-Pro-Y)2 cyclic hexapeptides. Preferred beta-turn conformers and implications for beta turns in proteins.

    Lila M. Gierasch;Charles M. Deber;Vincent Madison;Chien-Hua Niu

  • Conformations of Signal Peptides Induced by Lipids Suggest Initial Steps in Protein Export

    Martha S. Briggs;Donald G. Cornell;Richard A. Dluhy;Lila M. Gierasch

  • Signal sequences.

    Unknown

  • Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)

    B. Nagel;H. Dellweg;L. M. Gierasch

Frequent Co-Authors

Josep Rizo
Josep Rizo The University of Texas Southwestern Medical Center
Stanley J. Opella
Stanley J. Opella University of California, San Diego
Jean Rivier
Jean Rivier Salk Institute for Biological Studies
Alma L. Burlingame
Alma L. Burlingame University of California, San Francisco
Kerry-Anne Rye
Kerry-Anne Rye University of New South Wales
Nicholas O. Davidson
Nicholas O. Davidson Washington University in St. Louis
Ning Zheng
Ning Zheng University of Washington
Arthur L. Horwich
Arthur L. Horwich Yale University
George N. DeMartino
George N. DeMartino The University of Texas Southwestern Medical Center
Charles M. Deber
Charles M. Deber University of Toronto

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