World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
27434
World Ranking
5819
National Ranking
2754

Overview

Ning Zheng is affiliated with the University of Washington in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research spans over 100 publications, with a strong focus on molecular biology as well as interdisciplinary studies involving plant science, cardiology, radiology, and ecology.

The scientist's work prominently explores several specific research topics including:

  • Ubiquitin and proteasome pathways
  • Ion channel regulation and function
  • Protein degradation and inhibitors
  • Cardiac electrophysiology and arrhythmias
  • Plant molecular biology research
  • Nicotinic acetylcholine receptors study
  • Histone deacetylase inhibitors research

Ning Zheng has frequently published in several scientific venues, contributing multiple papers to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Molecular Cell

Their significant recent publications include:

  • "FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster" (2020, Molecular Cell)
  • "Structural basis of salicylic acid perception by Arabidopsis NPR proteins" (2020, Nature)
  • "An artificial intelligence accelerated virtual screening platform for drug discovery" (2024, Nature Communications)
  • "Defining molecular glues with a dual-nanobody cannabidiol sensor" (2022, Nature Communications)
  • "Open-state structure and pore gating mechanism of the cardiac sodium channel" (2021, Cell)

Ning Zheng has collaborated on multiple occasions with frequent co-authors, including:

  • Haibin Mao
  • William A. Catterall
  • Tamer M. Gamal El-Din
  • Shiyun Cao
  • Lige Tonggu

The breadth of Ning Zheng's research reflects a multidisciplinary approach, integrating molecular mechanisms with physiological function and potential applications in drug discovery and disease understanding. The areas of molecular biology, protein regulation, ion channel physiology, and plant molecular responses emerge as core components of their academic portfolio.

Best Publications

  • The crystal structure of a voltage-gated sodium channel

    Jian Payandeh;Todd Scheuer;Ning Zheng;William A. Catterall

  • Mechanism of auxin perception by the TIR1 ubiquitin ligase

    Xu Tan;Luz Irina A. Calderon-Villalobos;Michal Sharon;Changxue Zheng

  • Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

    Ning Zheng;Brenda A. Schulman;Brenda A. Schulman;Langzhou Song;Julie J. Miller

  • Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor

    Laura B Sheard;Xu-Hui Tan;Haibin Mao;John Withers

  • Ubiquitin Ligases: Structure, Function, and Regulation

    Ning Zheng;Nitzan Shabek

  • Structure of a c-Cbl–UbcH7 Complex: RING Domain Function in Ubiquitin-Protein Ligases

    Ning Zheng;Ping Wang;Philip D. Jeffrey;Nikola P. Pavletich

  • D14–SCF D3 -dependent degradation of D53 regulates strigolactone signalling

    Feng Zhou;Qibing Lin;Lihong Zhu;Yulong Ren

  • BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

    Haijuan Yang;Philip D. Jeffrey;Julie Miller;Elspeth Kinnucan

  • Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

    Stephane Angers;Ti Li;Xianhua Yi;Michael J. MacCoss

  • A combinatorial TIR1/AFB–Aux/IAA co-receptor system for differential sensing of auxin

    Luz Irina A Calderón Villalobos;Sarah Lee;Cesar De Oliveira;Anthony Ivetac

  • Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

    Jian Payandeh;Tamer M. Gamal El-Din;Todd Scheuer;Ning Zheng

  • Wilms Tumor Suppressor WTX Negatively Regulates WNT/β-Catenin Signaling

    Michael B. Major;Nathan D. Camp;Jason D. Berndt;Xianhua Yi

  • The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-β-catenin pathway by targeting Dishevelled for degradation

    Stephane Angers;Chris J. Thorpe;Travis L. Biechele;Seth J. Goldenberg

  • Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.

    Lin Tang;Tamer M. Gamal El-Din;Jian Payandeh;Gilbert Q. Martinez

  • Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F–DP

    Ning Zheng;Ernest Fraenkel;Carl O. Pabo;Nikola P. Pavletich

  • Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.

    Seth J. Goldenberg;Thomas C. Cascio;Stuart D. Shumway;Kenneth C. Garbutt

  • Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.

    Bing Hao;Bing Hao;Ning Zheng;Brenda A. Schulman;Geng Wu

  • Crystal structure of the plant dual-affinity nitrate transporter NRT1.1

    Ji Sun;John R. Bankston;Jian Payandeh;Thomas R. Hinds

  • Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.

    Ti Li;Xiujuan Chen;Kenneth C. Garbutt;Pengbo Zhou

  • Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

    Seth M. Rubin;Anne Laure Gall;Ning Zheng;Nikola P. Pavletich

Frequent Co-Authors

William A. Catterall
William A. Catterall University of Washington
Régis Pomès
Régis Pomès University of Toronto
Todd Scheuer
Todd Scheuer University of Washington
Brenda A. Schulman
Brenda A. Schulman Max Planck Society
Michele Pagano
Michele Pagano New York University
Nikola P. Pavletich
Nikola P. Pavletich Memorial Sloan Kettering Cancer Center
Randall T. Moon
Randall T. Moon University of Washington
Stephane Angers
Stephane Angers University of Toronto
Keiko U. Torii
Keiko U. Torii The University of Texas at Austin
Hui Wang
Hui Wang Hefei Institutes of Physical Science

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