World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
104
Citations
47787
World Ranking
1238
National Ranking
733

Research.com Recognitions

  • 2016 - Member of the National Academy of Sciences
  • 2011 - Fellow of the American Academy of Arts and Sciences
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Raymond J. Deshaies is affiliated with the California Institute of Technology in the United States. Their research spans key areas in biochemistry, genetics, and molecular biology, with significant contributions to medicine. The primary subfields of focus include molecular biology, epidemiology, cell biology, oncology, and biochemistry.

The scientist's work frequently addresses topics such as ubiquitin and proteasome pathways, protein degradation and inhibitors, endoplasmic reticulum stress and disease, autophagy in disease and therapy, liver disease diagnosis and treatment, lipid metabolism and biosynthesis, and peptidase inhibition and analysis.

Deshaies has published numerous articles in leading scientific venues. Frequent publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Nature
  • Molecular Cell
  • Proceedings of the National Academy of Sciences

Selected recent papers illustrate the themes and scope of their research:

  • Multispecific drugs herald a new era of biopharmaceutical innovation, 2020, Nature
  • Harnessing the Power of Proteolysis for Targeted Protein Inactivation, 2020, Molecular Cell
  • PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network, 2020, Molecular Cell
  • Assembly and Regulation of CRL Ubiquitin Ligases, 2020, Advances in Experimental Medicine and Biology
  • A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells, 2021, European Journal of Medicinal Chemistry

Collaboration is a notable feature of Deshaies' work. Frequent co-authors include:

  • David J. Sherman
  • Rati Verma
  • Michael J. Sweredoski
  • Jiansong Xie
  • John Ferbas

Recognition from the broader scientific community includes membership and fellowships in prestigious organizations. Awards received are:

  • Member of the National Academy of Sciences (2016)
  • Fellow of the American Academy of Arts and Sciences (2011)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2007)

Best Publications

  • RING Domain E3 Ubiquitin Ligases

    Raymond J. Deshaies;Claudio A. P. Joazeiro

  • Function and regulation of cullin-RING ubiquitin ligases.

    Matthew D. Petroski;Raymond J. Deshaies

  • Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation.

    Kathleen M. Sakamoto;Kyung B. Kim;Akiko Kumagai;Frank Mercurio

  • A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

    Raymond J. Deshaies;Bruce D. Koch;Margaret Werner-Washburne;Elizabeth A. Craig

  • How proteolysis drives the cell cycle

    Randall W. King;Raymond J. Deshaies;Jan-Michael Peters;Marc W. Kirschner

  • SCF and Cullin/RING H2-Based Ubiquitin Ligases

    Raymond J Deshaies

  • Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome

    Rati Verma;L. Aravind;Robert Oania;W. Hayes McDonald

  • A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

    R.M.Renny Feldman;Craig C Correll;Kenneth B Kaplan;Raymond J Deshaies

  • Exit from Mitosis Is Triggered by Tem1-Dependent Release of the Protein Phosphatase Cdc14 from Nucleolar RENT Complex

    Wenying Shou;Jae Hong Seol;Anna Shevchenko;Christopher Baskerville

  • Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1

    Gregory A. Cope;Greg S. B. Suh;L. Aravind;Sylvia E. Schwarz

  • Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome

    Svetlana Lyapina;Gregory Cope;Anna Shevchenko;Giovanna Serino

  • Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes

    Rati Verma;Stephen Chen;Renny Feldman;David Schieltz

  • Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

    Zdenek Skrott;Martin Mistrik;Klaus Kaae Andersen;Søren Friis

  • Phosphorylation of Sic1p by G1 Cdk Required for Its Degradation and Entry into S Phase

    R. Verma;R. S. Annan;M. J. Huddleston;S. A. Carr

  • Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF TIR1 in Mediating Auxin Response

    Claus Schwechheimer;Giovanna Serino;Judy Callis;William L. Crosby

  • Multiubiquitin Chain Receptors Define a Layer of Substrate Selectivity in the Ubiquitin-Proteasome System

    Rati Verma;Robert Oania;Johannes Graumann;Raymond J Deshaies

  • Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34.

    J. H. Seol;R.M. R. Feldman;W. Zachariae;A. Shevchenko

  • Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

    Anjanabha Saha;Raymond J. Deshaies

  • A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum.

    R J Deshaies;R Schekman

  • Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

    Senthil K. Radhakrishnan;Candy S. Lee;Patrick Young;Anne Beskow

Frequent Co-Authors

Sonja Hess
Sonja Hess AstraZeneca (United Kingdom)
Kathleen M. Sakamoto
Kathleen M. Sakamoto Stanford University
Randy Schekman
Randy Schekman University of California, Berkeley
Craig M. Crews
Craig M. Crews Yale University
Seth M. Cohen
Seth M. Cohen University of California, San Diego
Matthias Peter
Matthias Peter ETH Zurich
Hugh Rosen
Hugh Rosen Scripps Research Institute
John R. Yates
John R. Yates Scripps Research Institute
Andrej Shevchenko
Andrej Shevchenko Max Planck Society

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