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Best Scientists
2025
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Biology and Biochemistry
USA
2026

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Best Scientists

D-Index
215
Citations
197167
World Ranking
163
National Ranking
110

Biology and Biochemistry

D-Index
220
Citations
206814
World Ranking
19
National Ranking
16

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award

Overview

Steven P. Gygi is affiliated with Harvard University in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a strong focus on molecular biology and proteomics methodologies.

The scientist has contributed extensively to the field of proteomics, publishing a significant number of works related to advanced proteomics techniques and applications. Their research interests also include ubiquitin and proteasome pathways, mass spectrometry techniques, adipose tissue and metabolism, epigenetics and DNA methylation, endoplasmic reticulum stress and disease, and RNA modifications related to cancer.

Gygi's recent publications cover a range of topics primarily within the domain of cellular and molecular biology. Notable papers include:

  • Quantitative Proteomics of the Cancer Cell Line Encyclopedia, 2020, Cell
  • Dual proteome-scale networks reveal cell-specific remodeling of the human interactome, 2021, Cell
  • Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity, 2020, Cell
  • TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples, 2020, Nature Methods
  • A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics, 2021, Nature Biomedical Engineering

The scientist frequently publishes in several key journals and platforms, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Proteome Research
  • Cell
  • Nature
  • Molecular Cell

Gygi collaborates regularly with a number of researchers, with the most frequent co-authors including:

  • João A. Paulo
  • Qing Yu
  • Mark P. Jedrychowski
  • Tian Zhang
  • Devin K. Schweppe

Their scientific contributions largely emphasize biochemistry and genetics with an extensive publication record in molecular biology, spectroscopy, cell biology, immunology, and physiology. This breadth reflects a multidisciplinary approach within life sciences research.

Best Publications

  • Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

    Steven P. Gygi;Beate Rist;Scott A. Gerber;Frantisek Turecek

  • A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

    Pontus Boström;Jun Wu;Mark P. Jedrychowski;Anisha Korde

  • Correlation between Protein and mRNA Abundance in Yeast

    Steven P. Gygi;Yvan Rochon;B. Robert Franza;Ruedi Aebersold

  • The impact of microRNAs on protein output

    Daehyun Baek;Judit Villén;Chanseok Shin;Fernando D. Camargo

  • Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry

    Joshua E Elias;Steven P Gygi

  • Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

    Anne Brunet;Lora B. Sweeney;J. Fitzhugh Sturgill;Katrin F. Chua

  • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

    Joseph T. Rodgers;Carlos Lerin;Wilhelm Haas;Steven P. Gygi

  • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

    Shuhei Matsuoka;Bryan A. Ballif;Agata Smogorzewska;Agata Smogorzewska;E. Robert McDonald

  • Identification of a unique TGF-β–dependent molecular and functional signature in microglia

    Oleg Butovsky;Mark P Jedrychowski;Craig S Moore;Ron Cialic

  • Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer

    Klarisa Rikova;Ailan Guo;Qingfu Zeng;Anthony Possemato

  • Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS

    Scott A. Gerber;John Rush;Olaf Stemman;Marc W. Kirschner

  • A proteomics approach to understanding protein ubiquitination

    Junmin Peng;Junmin Peng;Daniel Schwartz;Joshua E Elias;Carson C Thoreen

  • Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.

    Junmin Peng;Joshua E. Elias;Carson C. Thoreen;Larry J. Licklider

  • Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology

    Steven P. Gygi;Garry L. Corthals;Yanni Zhang;Yvan Rochon

  • A quantitative atlas of mitotic phosphorylation.

    Noah Dephoure;Chunshui Zhou;Judit Villén;Sean A. Beausoleil

  • A tissue-specific atlas of mouse protein phosphorylation and expression.

    Edward L. Huttlin;Mark P. Jedrychowski;Joshua E. Elias;Tapasree Goswami

  • Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

    Joseph D. Mancias;Xiaoxu Wang;Steven P. Gygi;J. Wade Harper

  • Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

    Woong Kim;Eric J. Bennett;Edward L. Huttlin;Ailan Guo

  • A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

    Sean A Beausoleil;Judit Villén;Scott A Gerber;John Rush

  • Erratum: Identification of a unique TGF-β-dependent molecular and functional signature in microglia (Nature Neuroscience (2014) 17 (131-143))

    Oleg Butovsky;Mark P. Jedrychowski;Craig S. Moore;Ron Cialic

Frequent Co-Authors

Joao A. Paulo
Joao A. Paulo Harvard University
Mark P. Jedrychowski
Mark P. Jedrychowski Harvard University
Wilhelm Haas
Wilhelm Haas Harvard University
Judit Villén
Judit Villén University of Washington
J. Wade Harper
J. Wade Harper Harvard Medical School
Noah Dephoure
Noah Dephoure Cornell University
Scott A. Gerber
Scott A. Gerber Dartmouth College
Daniel Finley
Daniel Finley Harvard University
Danesh Moazed
Danesh Moazed Harvard University

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