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Biology and Biochemistry

D-Index
80
Citations
19564
World Ranking
4156
National Ranking
2036

Overview

Nancy L. Weigel is affiliated with Baylor College of Medicine in the United States. Their research primarily concentrates on areas within medicine and biochemistry, genetics, and molecular biology, with significant contributions to prostate cancer treatment and hormonal studies.

The scientist's work covers various subfields including pulmonary and respiratory medicine, endocrinology, diabetes and metabolism, genetics, molecular biology, and cancer research. Key topics investigated by Nancy L. Weigel include prostate cancer treatment and research, estrogen and related hormone effects, hormonal and reproductive studies, hormonal regulation and hypertension, protein degradation and inhibitors, RNA research and splicing, and RNA and protein synthesis mechanisms.

Frequent coauthors collaborating with Nancy L. Weigel include Cristian Coarfa, Paul Basil, Matthew J. Robertson, Amit K. Dash, and Danthasinghe Waduge Badrajee Piyarathna.

The scientist has multiple publications in the following venues: Scientific Reports, IUPHAR/BPS Guide to Pharmacology CITE, Endocrinology, Cells, and Research Square (Research Square).

Recent publications by Nancy L. Weigel highlight the focus on androgen receptor splice variants, mRNA splicing, and cancer biology:

  • "Cistrome and transcriptome analysis identifies unique androgen receptor (AR) and AR-V7 splice variant chromatin binding and transcriptional activities", 2022, Scientific Reports
  • "Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells", 2021, Scientific Reports
  • "Isoform-specific Activities of Androgen Receptor and its Splice Variants in Prostate Cancer Cells", 2020, Endocrinology
  • "3C. 3-Ketosteroid receptors in GtoPdb v.2023.1", 2023, IUPHAR/BPS Guide to Pharmacology CITE
  • "Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients", 2022, Cells

Best Publications

  • Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

    Sophia Y. Tsai;Jan Carlstedt-Duke;Nancy L. Weigel;Karin Dahlman

  • ACTIVATION OF THE HUMAN ANDROGEN RECEPTOR THROUGH A PROTEIN KINASE A SIGNALING PATHWAY

    Lynne V. Nazareth;Nancy L. Weigel

  • International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors

    Nick Z. Lu;Suzanne E. Wardell;Kerry L. Burnstein;Donald Defranco

  • Polyglutamine-Expanded Androgen Receptors Form Aggregates That Sequester Heat Shock Proteins, Proteasome Components and SRC-1, and Are Suppressed by the HDJ-2 Chaperone

    David L. Stenoien;Chris J. Cummings;Henry P. Adams;Maureen G. Mancini

  • Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

    G. F. Allan;X. Leng;S. Y. Tsai;N. L. Weigel

  • Steroid hormone receptors and their regulation by phosphorylation.

    Nancy L Weigel

  • Regulation of progesterone receptor-mediated transcription by phosphorylation

    Larry A. Denner;Nancy L. Weigel;Beth L. Maxwell;William T. Schrader

  • Androgen Receptor Mutations in Prostate Cancer

    Marco Marcelli;Michael Ittmann;Stefania Mariani;Richard Sutherland

  • Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress.

    Gary D. Hammer;Irina Krylova;Yixian Zhang;Beatrice D. Darimont

  • Androgen receptors in hormone-dependent and castration-resistant prostate cancer.

    Ayesha A. Shafi;Aihua E. Yen;Nancy L. Weigel

  • Phosphorylation of Steroid Receptor Coactivator-1 IDENTIFICATION OF THE PHOSPHORYLATION SITES AND PHOSPHORYLATION THROUGH THE MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY

    Brian G. Rowan;Nancy L. Weigel;Bert W. O'Malley

  • The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor

    Brandee L. Wagner;John D. Norris;Trina A. Knotts;Nancy L. Weigel

  • 8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein

    Brian G. Rowan;Nefretiti Garrison;Nancy L. Weigel;Bert W. O'Malley

  • Direct G Protein Modulation of Cav2 Calcium Channels

    H. William Tedford;Gerald W. Zamponi

  • 1,25-dihydroxyvitamin D3 and 9-cis-retinoic acid act synergistically to inhibit the growth of LNCaP prostate cells and cause accumulation of cells in G1.

    S E Blutt;E A Allegretto;J W Pike;N L Weigel

  • The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex.

    Ludger Klein-Hitpass;Sophia Y. Tsai;Nancy L. Weigel;George F. Allan

  • The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

    Candace A. Beck;Nancy L. Weigel;Marissa L. Moyer;Steven K. Nordeen

  • Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2.

    Sarah E. Blutt;Timothy J. Mcdonnell;Tara C. Polek;Nancy L. Weigel

  • Role of SRC-1 in the Promotion of Prostate Cancer Cell Growth and Tumor Progression

    Irina U. Agoulnik;Ajula Vaid;William E. Bingman;Halime Erdeme

  • Vitamin D and prostate cancer.

    Sarah E. Blutt;Nancy L. Weigel

Frequent Co-Authors

Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
Dean P. Edwards
Dean P. Edwards Baylor College of Medicine
William T. Schrader
William T. Schrader Baylor College of Medicine
Michael Ittmann
Michael Ittmann Baylor College of Medicine
Cristian Coarfa
Cristian Coarfa Baylor College of Medicine
Angelo Poletti
Angelo Poletti University of Milan
Donald P. McDonnell
Donald P. McDonnell Duke University
Ming-Jer Tsai
Ming-Jer Tsai Baylor College of Medicine
Sophia Y. Tsai
Sophia Y. Tsai Baylor College of Medicine
Nagireddy Putluri
Nagireddy Putluri Baylor College of Medicine

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