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Molecular Biology

D-Index
73
Citations
20554
World Ranking
1271
National Ranking
654

Overview

Orla M. Conneely is affiliated with Baylor College of Medicine in the United States. Their research spans multiple areas within the broader field of biochemistry, genetics, and molecular biology, with a particular focus on molecular biology.

The scientist's work covers several main topics, including:

  • Protein Degradation and Inhibitors
  • RNA Interference and Gene Delivery
  • Histone Deacetylase Inhibitors Research

Conneely has contributed to research published in venues such as Scientific Reports, among others. Notably, a recent paper includes:

  • Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors (2020, Scientific Reports)

The publication reflects an interest in regulatory mechanisms in cancer biology, specifically acute myeloid leukemia, and explores molecular activators with therapeutic potential.

Collaborative work forms a key element of Conneely's research, involving frequent coauthors including S. Greg Call, Ryan P. Duren, Anil K. Panigrahi, Loc T. Nguyen, and Pablo R. Freire.

Their research profile is characterized by integration of molecular biology techniques aimed at understanding and modulating key biological processes such as protein degradation pathways and gene delivery mechanisms. This intersection supports investigation into epigenetic regulators, including histone deacetylase inhibitors, demonstrating the scientist's focus on molecular targets relevant to disease pathways and potential interventions.

Best Publications

  • Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

    J. P. Lydon;F. J. Demayo;C. R. Funk;S. K. Mani

  • Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons.

    Odila Saucedo-Cardenas;Juan D. Quintana-Hau;Wei-Dong Le;Marten P. Smidt

  • Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform

    Biserka Mulac-Jericevic;Robert A. Mullinax;Francesco J. DeMayo;John P. Lydon

  • Dopaminergic and ligand-independent activation of steroid hormone receptors.

    Ronan F. Power;Shaila K. Mani;Juan Codina;Orla M. Conneely

  • Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

    Biserka Mulac-Jericevic;John P. Lydon;Francesco J. DeMayo;Orla M. Conneely

  • Multifunctional roles of lactoferrin: a critical overview.

    Unknown

  • Identification of a new brain-specific transcription factor, NURR1.

    S W Law;O M Conneely;F J DeMayo;B W O'Malley

  • Reproductive functions of progesterone receptors.

    Orla M Conneely;Biserka Mulac-Jericevic;Francesco DeMayo;John P Lydon

  • Abrogation of nuclear receptors Nr4a3 andNr4a1 leads to development of acute myeloid leukemia

    Shannon E Mullican;Shuo Zhang;Marina Konopleva;Vivian Ruvolo

  • Lactoferrin and host defense.

    Unknown

  • Reproductive phenotpes of the progesterone receptor null mutant mouse.

    John P. Lydon;Francesco J. DeMayo;Orla M. Conneely;Bert W. O'Malley

  • Reproductive tissue selective actions of progesterone receptors

    Unknown

  • Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone.

    Carolyn L. Smith;Orla M. Conneely;Bert W. O'Malley

  • Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms.

    Orla M. Conneely;Biserka Mulac-Jericevic;John P. Lydon

  • Molecular Cloning of the Chicken Progesterone Receptor

    Orla M. Conneely;William P. Sullivan;David O. Toft;Mariel Birnbaumer

  • Reproductive functions of the progesterone receptor isoforms: lessons from knock-out mice

    Orla M. Conneely;Biserka Mulac-Jericevic;John P. Lydon;Francesco J. De Mayo

  • Progesterone receptors in reproduction: functional impact of the A and B isoforms

    Orla M Conneely;John P Lydon

  • The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA.

    Orla M. Conneely;Beth Lynn Maxwell;David O. Toft;William T. Schrader

  • Dopamine activation of an orphan of the steroid receptor superfamily.

    Ronan F. Power;John P. Lydon;Orla M. Conneely;Bert W. O'Malley

  • The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event.

    O. M. Conneely;D. M. Kettelberger;Ming-Jer Tsai;W. T. Schrader

Frequent Co-Authors

Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
John P. Lydon
John P. Lydon Baylor College of Medicine
William T. Schrader
William T. Schrader Baylor College of Medicine
Gregory S. May
Gregory S. May The University of Texas MD Anderson Cancer Center
Francesco J. DeMayo
Francesco J. DeMayo National Institutes of Health
Rebecca J. Dearman
Rebecca J. Dearman University of Manchester
Marie Cumberbatch
Marie Cumberbatch AstraZeneca (United Kingdom)
Daniel Medina
Daniel Medina Baylor College of Medicine
Ian Kimber
Ian Kimber University of Manchester
Alan D. W. Dobson
Alan D. W. Dobson University College Cork

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