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Biology and Biochemistry

D-Index
145
Citations
92351
World Ranking
217
National Ranking
150

Medicine

D-Index
144
Citations
88483
World Ranking
1433
National Ranking
835

Overview

Stephen Safe is affiliated with Texas A&M University in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, neuroscience, and medicine. Their scholarly work spans several key subfields such as cellular and molecular neuroscience, molecular biology, immunology, health, toxicology and mutagenesis, and oncology.

Their research covers a wide array of main topics, notably nuclear receptors and signaling, macrophage migration inhibitory factor, toxic organic pollutants impact, RNA interference and gene delivery, effects and risks of endocrine disrupting chemicals, circular RNAs in diseases, and synthesis of tetrazole derivatives.

Stephen Safe has published prolifically in various academic journals. The most frequent publication venues include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • International Journal of Molecular Sciences
  • Cancer Research
  • Cancers
  • American Journal of Physiology-Gastrointestinal and Liver Physiology

Among their recent papers are:

  • "Flavonoids: structure-function and mechanisms of action and opportunities for drug development" (2021) in Toxicological Research
  • "The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer" (2020) in Molecular Cancer Research
  • "Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs)" (2020) in International Journal of Molecular Sciences
  • "Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action" (2023) in International Journal of Molecular Sciences

Notable frequent co-authors collaborating with Stephen Safe include:

  • Robert S. Chapkin
  • Arul Jayaraman
  • Kumaravel Mohankumar
  • Rupesh Shrestha
  • Amanuel Hailemariam

Best Publications

  • Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

    George G.J.M. Kuiper;Josephine G. Lemmen;Bo Carlsson;J. Christopher Corton

  • The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.

    Martin Van den Berg;Linda S. Birnbaum;Michael Denison;Mike De Vito

  • Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife

    M. van den Berg;L. Birnbaum;A.T.C. Bosveld;B. Brunstrom

  • Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).

    Stephen Safe

  • Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment

    Stephen H. Safe

  • Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action

    S Safe

  • Toxic equivalency factors for dioxin-like PCBs. Report on WHO-ECEH and IPCS consultation, December 1993

    U. G. Ahlborg;G. C. Becking;L. S. Birnbaum;A. Brouwer

  • The Chemistry of PCB's

    O. Hutzinger;S. Safe;V. Zitko

  • Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

    S H Safe

  • HOTAIR IS A NEGATIVE PROGNOSTIC FACTOR AND EXHIBITS PRO-ONCOGENIC ACTIVITY IN PANCREATIC CANCER

    KyoungHyun Kim;Indira Jutooru;Gayathri Chadalapaka;Greg Johnson

  • High-resolution PCB analysis: synthesis and chromatographic properties of all 209 PCB congeners

    Michael D. Mullins;Cynthia M. Pochini;Shelia. McCrindle;Marjorie. Romkes

  • Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR

    Wen Xie;Joyce L. Barwick;Cynthia M. Simon;Alexis M. Pierce

  • Sp transcription factor family and its role in cancer

    Stephen Safe;Stephen Safe;Maen Abdelrahim

  • Environmental and dietary estrogens and human health: is there a problem?

    Stephen H. Safe

  • Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol

    Janet C. Gould;Linda S. Leonard;Susan C. Maness;Brandee L. Wagner

  • Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions.

    Stephen Safe

  • The Oncogenic microRNA-27a Targets Genes That Regulate Specificity Protein Transcription Factors and the G2-M Checkpoint in MDA-MB-231 Breast Cancer Cells

    Susanne U. Mertens-Talcott;Sudhakar Chintharlapalli;Xiangrong Li;Stephen Safe

  • Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems.

    Stephen Safe

  • Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements

    Brad Saville;Mark Wormke;Fan Wang;Thu Nguyen

  • Functional Synergy between the Transcription Factor Sp1 and the Estrogen Receptor

    W. Porter;B. Saville;D. Hoivik;S. Safe

Frequent Co-Authors

Robert C. Burghardt
Robert C. Burghardt Texas A&M University
Robert S. Chapkin
Robert S. Chapkin Texas A&M University
Ismael Samudio
Ismael Samudio Abdera Therapeutics
Arul Jayaraman
Arul Jayaraman Texas A&M University
Roger Smith
Roger Smith University of Newcastle Australia
Timothy D. Phillips
Timothy D. Phillips Texas A&M University
Marina Konopleva
Marina Konopleva The University of Texas MD Anderson Cancer Center
Lawrence S.B. Goldstein
Lawrence S.B. Goldstein University of California, San Diego
Michael Andreeff
Michael Andreeff The University of Texas MD Anderson Cancer Center
Donald P. McDonnell
Donald P. McDonnell Duke University

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