His primary scientific interests are in Internal medicine, Endocrinology, Cancer research, Receptor and Molecular biology. The study incorporates disciplines such as In vitro and Mechanism of action in addition to Internal medicine. His study looks at the relationship between Endocrinology and topics such as Cancer, which overlap with Pancreatic disease.
His Cancer research research incorporates elements of Cancer cell, Pancreatic cancer, Cell growth and Transcription factor. His Receptor research integrates issues from Nuclear receptor, Aryl hydrocarbon receptor and In vivo. The various areas that Stephen Safe examines in his Molecular biology study include Promoter, Gene expression, Sp1 transcription factor, Transactivation and Transfection.
Internal medicine, Endocrinology, Cancer research, Molecular biology and Biochemistry are his primary areas of study. His research brings together the fields of Mechanism of action and Internal medicine. Stephen Safe interconnects Agonist, Receptor, Antiestrogen, Estrogen receptor and Toxicity in the investigation of issues within Endocrinology.
His research investigates the connection between Receptor and topics such as Stereochemistry that intersect with issues in Aryl. His studies deal with areas such as Cancer cell, Cancer, Cell growth, Apoptosis and Transcription factor as well as Cancer research. His research investigates the connection with Molecular biology and areas like Transfection which intersect with concerns in Reporter gene.
His primary areas of investigation include Cancer research, Cell growth, Aryl hydrocarbon receptor, Gene knockdown and Molecular biology. Stephen Safe combines subjects such as Cancer cell, Apoptosis, Nuclear receptor, Transcription factor and Downregulation and upregulation with his study of Cancer research. He has researched Cell growth in several fields, including Cell culture, Transfection, Survivin and Metastasis.
His Aryl hydrocarbon receptor study is focused on Biochemistry in general. His work deals with themes such as Endocrinology, Pancreatic cancer, RNA interference, Internal medicine and HOTAIR, which intersect with Gene knockdown. His Molecular biology research is multidisciplinary, relying on both Histone deacetylase and Transactivation.
Stephen Safe spends much of his time researching Cancer research, Gene knockdown, Molecular biology, Downregulation and upregulation and Cell growth. His Cancer research study combines topics from a wide range of disciplines, such as Cancer cell, Cancer, Internal medicine, Endocrinology and Transcription factor. His work in the fields of Endocrinology, such as Dopaminergic, intersects with other areas such as Neuroglia.
His Gene knockdown research includes elements of Repressor, RNA interference and Pancreatic cancer. His study focuses on the intersection of Molecular biology and fields such as Vorinostat with connections in the field of Caco-2. His Cell growth study also includes
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Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G.J.M. Kuiper;Josephine G. Lemmen;Bo Carlsson;J. Christopher Corton.
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife
M. van den Berg;L. Birnbaum;A.T.C. Bosveld;B. Brunstrom.
Environmental Health Perspectives (1998)
The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.
Martin Van den Berg;Linda S. Birnbaum;Michael Denison;Mike De Vito.
Toxicological Sciences (2006)
Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).
Critical Reviews in Toxicology (1990)
Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment
Stephen H. Safe.
Critical Reviews in Toxicology (1994)
Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action
Critical Reviews in Toxicology (1984)
Toxic equivalency factors for dioxin-like PCBs. Report on WHO-ECEH and IPCS consultation, December 1993
U. G. Ahlborg;G. C. Becking;L. S. Birnbaum;A. Brouwer.
The Chemistry of PCB's
O. Hutzinger;S. Safe;V. Zitko.
Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans
S H Safe.
Annual Review of Pharmacology and Toxicology (1986)
HOTAIR IS A NEGATIVE PROGNOSTIC FACTOR AND EXHIBITS PRO-ONCOGENIC ACTIVITY IN PANCREATIC CANCER
KyoungHyun Kim;Indira Jutooru;Gayathri Chadalapaka;Greg Johnson.
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