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Ismael Samudio

Ismael Samudio

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
12035
World Ranking
16547
National Ranking
581

Overview

Ismael Samudio is affiliated with Abdera Therapeutics in Canada and has a research focus largely centered on virus-based gene therapy and oncology. Their work intersects multiple fields, including Medicine and Biochemistry, Genetics and Molecular Biology, and extends to subfields such as Genetics, Oncology, Epidemiology, Molecular Biology, and Animal Science and Zoology.

Their research covers several key topics in biomedical science, including:

  • Virus-based gene therapy research
  • Herpesvirus Infections and Treatments
  • CAR-T cell therapy research
  • Animal Virus Infections Studies
  • Galectins and Cancer Biology
  • Glycosylation and Glycoproteins Research
  • Monoclonal and Polyclonal Antibodies Research

Samudio has published in a variety of journals and venues, frequently appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biomedicines
  • Viruses
  • Journal for ImmunoTherapy of Cancer
  • Cancer Medicine

Recent publications demonstrate a focus on oncolytic virotherapy and tumor immunology, including:

  • Induction of Durable Antitumor Response by a Novel Oncolytic Herpesvirus Expressing Multiple Immunomodulatory Transgenes (2020) in Biomedicines
  • Pre-Existing HSV-1 Immunity Enhances Anticancer Efficacy of a Novel Immune-Stimulating Oncolytic Virus (2022) in Viruses
  • PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin (2020) in Journal for ImmunoTherapy of Cancer
  • Oncolytic virotherapy in hepato-bilio-pancreatic cancer: The key to breaking the log jam? (2020) in Cancer Medicine
  • Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1 (2023) in Molecular Therapy - Oncolytics

Collaborations have been a noteworthy aspect of Samudio's career, with frequent co-authors including:

  • Jun Ding
  • William Jia
  • Yanal Murad
  • Yi Sun
  • Ronghua Zhao

The combination of their multidisciplinary research interests with extensive collaboration and publications in peer-reviewed journals reflects a comprehensive engagement in the fields of viral therapies, cancer biology, and immunotherapy.

Best Publications

  • Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

    Marina Konopleva;Rooha Contractor;Twee Tsao;Ismael Samudio

  • Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

    Ismael Samudio;Romain Harmancey;Michael Fiegl;Hagop Kantarjian

  • Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

    Zhihong Zeng;Yue Xi Shi;Ismael J. Samudio;Rui Yu Wang

  • Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways

    Paolo Calabro;Ismael Samudio;James T. Willerson;James T. Willerson;Edward T.H. Yeh

  • MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.

    Kensuke Kojima;Marina Konopleva;Marina Konopleva;Ismael J. Samudio;Ismael J. Samudio;Masato Shikami;Masato Shikami

  • Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

    Zhihong Zeng;Dos D. Sarbassov;Dos D. Sarbassov;Ismael J. Samudio;Karen W. L. Yee

  • Mitochondrial uncoupling and the Warburg effect: Molecular basis for the reprogramming of cancer cell metabolism

    Ismael Samudio;Michael Fiegl;Michael Andreeff

  • Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells.

    Lian Dong;Weili Wang;Fan Wang;Matthew Stoner

  • Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)

    Marina Konopleva;Julie Watt;Rooha Contractor;Twee Tsao

  • Effects of natural antioxidants in neurodegenerative disease

    Sonia Luz Albarracin;Ben Stab;Zulma Casas;Jhon Jairo Sutachan

  • Estrogen Regulation of Cyclin D1 Gene Expression in ZR-75 Breast Cancer Cells Involves Multiple Enhancer Elements

    Emely Castro-Rivera;Ismael Samudio;Stephen Safe

  • 3,3′-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5

    Maen Abdelrahim;Kristen Newman;Kathy Vanderlaag;Ismael Samudio

  • Mesenchymal stromal cells alone or expressing interferon-β suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment

    Shannon Kidd;Lisa Caldwell;Martin Dietrich;Ismael Samudio

  • Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias

    Zhihong Zeng;Ismael J. Samudio;Mark Munsell;Jing An

  • Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells.

    Stephen Safe;Mark Wormke;Ismael Samudio

  • The Warburg Effect in Leukemia-Stroma Cocultures Is Mediated by Mitochondrial Uncoupling Associated with Uncoupling Protein 2 Activation

    Ismael Samudio;Michael Fiegl;Teresa McQueen;Karen Clise-Dwyer

  • Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins.

    Matthew Stoner;Mark Wormke;Brad Saville;Ismael Samudio

  • A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia.

    Rooha Contractor;Ismael J. Samudio;Zeev Estrov;David Harris

  • CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure

    Michael Fiegl;Ismael Samudio;Karen Clise-Dwyer;Jared K. Burks

  • Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.

    Polina Matre;Juliana Velez;Rodrigo Jacamo;Yuan Qi

Frequent Co-Authors

Michael Andreeff
Michael Andreeff The University of Texas MD Anderson Cancer Center
Marina Konopleva
Marina Konopleva The University of Texas MD Anderson Cancer Center
Stephen Safe
Stephen Safe Texas A&M University
Hagop M. Kantarjian
Hagop M. Kantarjian The University of Texas MD Anderson Cancer Center
Zeev Estrov
Zeev Estrov The University of Texas MD Anderson Cancer Center
Steven M. Kornblau
Steven M. Kornblau The University of Texas MD Anderson Cancer Center
James A. McCubrey
James A. McCubrey East Carolina University
Gerald Krystal
Gerald Krystal BC Cancer Agency
Robert C. Burghardt
Robert C. Burghardt Texas A&M University
George E. Barreto
George E. Barreto University of Limerick

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