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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
15043
World Ranking
13014
National Ranking
5549

Overview

Leslie Crews is affiliated with the University of California, San Diego in the United States. Their research spans several areas in biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, hematology, immunology, oncology, and cardiology and cardiovascular medicine.

Their work is prominently connected to the study of multiple myeloma, RNA research and splicing, protein degradation and inhibitors, ubiquitin and proteasome pathways, acute myeloid leukemia, RNA regulation and disease, and immune cell function and interaction. These topics reflect a concentration on both the molecular mechanisms underlying hematologic malignancies and broader immune system functions.

Recent publications by Leslie Crews include:

  • Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption, 2021, Cell stem cell
  • Reversal of malignant ADAR1 splice isoform switching with Rebecsinib, 2023, Cell stem cell
  • Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution, 2021, Cell Reports
  • Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells, 2023, Cell Reports Medicine
  • Sensitive intranuclear flow cytometric quantification of IRF4 protein in multiple myeloma and normal human hematopoietic cells, 2021, STAR Protocols

They have frequently published in scientific journals such as Blood, Cancer Research, Cell stem cell, bioRxiv (Cold Spring Harbor Laboratory), and Cell Reports, demonstrating a concentrated publication history in high-impact hematology and cancer research venues.

Leslie Crews has collaborated extensively with several researchers, including Catriona Jamieson, Phoebe Mondala, Silvia Vicenzi, Ashni A. Vora, and Thomas Whisenant. These collaborations have been part of the collective research efforts reflecting their main areas of expertise.

Best Publications

  • Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.

    Paula Desplats;He Jin Lee;Eun Jin Bae;Christina Patrick

  • Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease

    Leslie Crews;Eliezer Masliah

  • Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.

    Makoto Hashimoto;Edward Rockenstein;Leslie Crews;Eliezer Masliah

  • Effects of α-Synuclein Immunization in a Mouse Model of Parkinson’s Disease

    Eliezer Masliah;Edward Rockenstein;Anthony Adame;Michael Alford

  • Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

    Oded Singer;Robert A Marr;Edward Rockenstein;Leslie Crews

  • Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

    Eliezer Masliah;Edward Rockenstein;Michael Mante;Leslie Crews

  • Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

    E. Masliah;L. Hansen;A. Adame;L. Crews

  • Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications

    Benjamin D. Sullivan;Leslie A. Crews;Elisabeth M. Messmer;Gary N. Foulks

  • Neuroprotective Effects of Regulators of the Glycogen Synthase Kinase-3β Signaling Pathway in a Transgenic Model of Alzheimer's Disease Are Associated with Reduced Amyloid Precursor Protein Phosphorylation

    Edward Rockenstein;Magdalena Torrance;Anthony Adame;Michael Mante

  • Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

    Leslie A Crews;Brian Spencer;Paula Desplats;Christina Patrick

  • Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology

    Ina Tesseur;Kun Zou;Luke Esposito;Frederique Bard

  • Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases

    Igor F. Tsigelny;Leslie Crews;Paula Desplats;Gideon M. Shaked

  • Progressive accumulation of amyloid‐β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

    Emiley Pham;Leslie Crews;Kiren Ubhi;Lawrence Hansen

  • Neurological and Neurodegenerative Alterations in a Transgenic Mouse Model Expressing Human α-Synuclein under Oligodendrocyte Promoter: Implications for Multiple System Atrophy

    Clifford W. Shults;Edward Rockenstein;Leslie Crews;Anthony Adame

  • Clinical utility of objective tests for dry eye disease: variability over time and implications for clinical trials and disease management.

    Benjamin D Sullivan;Leslie A Crews;Barış Sönmez;Maria F de la Paz

  • Increased BMP6 levels in the brains of Alzheimer’s disease patients and APP transgenic mice are accompanied by impaired neurogenesis

    Leslie Crews;Anthony Adame;Christina Patrick;Alexandra DeLaney

  • ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

    Maria Anna Zipeto;Angela C. Court;Anil Sadarangani;Nathaniel P. Delos Santos

  • Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux

    Roberta Marongiu;Brian Spencer;Leslie Crews;Anthony Adame

  • Dynamics of α‐synuclein aggregation and inhibition of pore‐like oligomer development by β‐synuclein

    Igor F. Tsigelny;Pazit Bar-On;Yuriy Sharikov;Leslie Crews

  • Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.

    Igor F. Tsigelny;Yuriy Sharikov;Wolfgang Wrasidlo;Tania Gonzalez

Frequent Co-Authors

Eliezer Masliah
Eliezer Masliah National Institutes of Health
Edward Rockenstein
Edward Rockenstein University of California, San Diego
Michael Mante
Michael Mante University of California, San Diego
Mark D. Minden
Mark D. Minden Princess Margaret Cancer Centre
Igor Grant
Igor Grant University of California, San Diego
Edward D. Ball
Edward D. Ball University of California, San Diego
Michael D. Burkart
Michael D. Burkart University of California, San Diego
Lawrence A. Hansen
Lawrence A. Hansen University of California, San Diego
Fred H. Gage
Fred H. Gage Salk Institute for Biological Studies
Kelly A. Frazer
Kelly A. Frazer University of California, San Diego

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