H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Medicine D-index 180 Citations 127,768 667 World Ranking 120 National Ranking 84

Research.com Recognitions

Awards & Achievements

2020 - Breakthrough Prize in Life Sciences for discovering TDP43 protein aggregates in frontotemporal dementia and amyotrophic lateral sclerosis, and revealing that different forms of alpha-synuclein, in different cell types, underlie Parkinson’s disease and Multiple System Atrophy.

2014 - J. Allyn Taylor International Prize in Medicine, Robarts Research Institute

2013 - Fellow of the American Academy of Arts and Sciences

2012 - Fellow, National Academy of Inventors

2012 - Robert J. and Claire Pasarow Foundation Medical Research Award

2005 - Member of the National Academy of Medicine (NAM)

1998 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

1998 - Sedgwick Memorial Medal, American Public Health Association

1996 - Metlife Foundation Award for Medical Research in Alzheimer's Disease

1966 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Enzyme
  • Internal medicine

Virginia M.-Y. Lee spends much of her time researching Pathology, Neuroscience, Cell biology, Alzheimer's disease and Alpha-synuclein. Her work deals with themes such as Central nervous system disease and Central nervous system, which intersect with Pathology. The concepts of her Neuroscience study are interwoven with issues in Dementia, Neurodegeneration, Parkinson's disease, Disease and Genetically modified mouse.

Her studies in Cell biology integrate themes in fields like Neurofilament, Fibril, Biochemistry, Mutant and Anatomy. Her Alzheimer's disease research is multidisciplinary, incorporating elements of Cerebrospinal fluid and Tauopathy. Virginia M.-Y. Lee interconnects Lewy body, Protein structure and Substantia nigra in the investigation of issues within Alpha-synuclein.

Her most cited work include:

  • α-Synuclein in Lewy bodies (5545 citations)
  • Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (4135 citations)
  • Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium (3883 citations)

What are the main themes of her work throughout her whole career to date?

Virginia M.-Y. Lee focuses on Pathology, Neuroscience, Cell biology, Alzheimer's disease and Disease. Her study in Pathology focuses on Frontotemporal lobar degeneration, Dementia, Amyotrophic lateral sclerosis, Tau protein and Frontotemporal dementia. The Neuroscience study combines topics in areas such as Neurodegeneration, Tauopathy and Parkinson's disease, Alpha-synuclein.

Her research investigates the link between Alpha-synuclein and topics such as Lewy body that cross with problems in Synucleinopathies. Her work carried out in the field of Cell biology brings together such families of science as Cell culture, Neurofilament and Biochemistry. Her Alzheimer's disease research is multidisciplinary, relying on both Degenerative disease and Amyloid.

She most often published in these fields:

  • Pathology (33.99%)
  • Neuroscience (22.91%)
  • Cell biology (19.72%)

What were the highlights of her more recent work (between 2012-2021)?

  • Pathology (33.99%)
  • Neuroscience (22.91%)
  • Disease (15.87%)

In recent papers she was focusing on the following fields of study:

The scientist’s investigation covers issues in Pathology, Neuroscience, Disease, Cell biology and Frontotemporal lobar degeneration. Her Pathology study frequently links to adjacent areas such as White matter. Her Neuroscience research incorporates themes from Senile plaques, Amyloid, Protein aggregation and Tauopathy.

Her Cell biology study incorporates themes from Fibril, Biochemistry, Tau pathology and Alpha-synuclein. Her studies in Frontotemporal lobar degeneration integrate themes in fields like Amyotrophic lateral sclerosis and Atrophy. The study incorporates disciplines such as Lewy body and Dementia with Lewy bodies in addition to Synucleinopathies.

Between 2012 and 2021, her most popular works were:

  • Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis (534 citations)
  • Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls (530 citations)
  • Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis (450 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

Her primary areas of investigation include Neuroscience, Pathology, Alpha-synuclein, Frontotemporal lobar degeneration and Amyotrophic lateral sclerosis. Her research in Neuroscience intersects with topics in Protein aggregation and Alzheimer's disease, Neurodegeneration, Disease, Tauopathy. Her study in Pathology is interdisciplinary in nature, drawing from both White matter and Entorhinal cortex.

Her studies deal with areas such as Substantia nigra, Neurite, Amyloid and Cell biology as well as Alpha-synuclein. Her Cell biology research is multidisciplinary, incorporating elements of Fibril, Biochemistry, Neuron and Synucleinopathies. Virginia M.-Y. Lee combines subjects such as Axoplasmic transport and Spinal cord with her study of Amyotrophic lateral sclerosis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

α-Synuclein in Lewy bodies

Maria Grazia Spillantini;Marie Luise Schmidt;Virginia M.-Y. Lee;John Q. Trojanowski.
Nature (1997)

7698 Citations

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Manuela Neumann;Deepak M. Sampathu;Linda K. Kwong;Adam C. Truax.
Science (2006)

5207 Citations

Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium

I. G. McKeith;I. G. McKeith;D. W. Dickson;J. Lowe;M. Emre.
Neurology (2005)

4931 Citations

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.

Carlo Ballatore;Virginia M.-Y. Lee;John Q. Trojanowski.
Nature Reviews Neuroscience (2007)

2119 Citations

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.

Leslie M. Shaw;Hugo Vanderstichele;Malgorzata Knapik-Czajka;Christopher M. Clark.
Annals of Neurology (2009)

1829 Citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Benoit I. Giasson;John E. Duda;Ian V. J. Murray;Qiping Chen.
Science (2000)

1759 Citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

M. Baba;S. Nakajo;P.-H. Tu;T. Tomita.
American Journal of Pathology (1998)

1731 Citations

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

Kelvin C. Luk;Victoria Kehm;Jenna Carroll;Bin Zhang.
Science (2012)

1695 Citations

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau

Virginia M. Y. Lee;Brian J. Balin;Laszlo Otvos;John Q. Trojanowski.
Science (1991)

1687 Citations

Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

Pavan K. Auluck;H. Y. Edwin Chan;John Q. Trojanowski;Virginia M.-Y. Lee.
Science (2002)

1447 Citations

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