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Biology and Biochemistry

D-Index
55
Citations
13808
World Ranking
14869
National Ranking
6223

Overview

Kurt R. Brunden is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on the field of Medicine, with significant contributions across several subfields including Physiology, Neurology, Molecular Biology, Organic Chemistry, and Materials Chemistry.

The scientist's work encompasses various main topics, particularly:

  • Alzheimer's disease research and treatments
  • Trypanosoma species research and implications
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Prion Diseases and Protein Misfolding
  • Click Chemistry and Applications
  • Computational Drug Discovery Methods
  • Cholinesterase and Neurodegenerative Diseases

Publications by Kurt R. Brunden have appeared in multiple venues, with repeated appearances in:

  • Acta Neuropathologica
  • Alzheimer's & Dementia
  • ChemMedChem
  • The Cambridge Structural Database
  • Journal of Medicinal Chemistry

Recent papers authored or co-authored by Kurt R. Brunden include:

  • Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease, 2021, Acta Neuropathologica
  • Characterization of tau binding by gosuranemab, 2020, Neurobiology of Disease
  • Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice, 2021, Acta Neuropathologica Communications
  • In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics, 2021, Acta Neuropathologica
  • Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease, 2020, Molecular Neurodegeneration

Kurt R. Brunden collaborates frequently with a range of researchers. Among their most frequent co-authors are:

  • Virginia M.-Y. Lee
  • Carlo Ballatore
  • John Q. Trojanowski
  • Thibault Alle
  • Bobby Lucero

Best Publications

  • ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.

    Paige E. Cramer;John R. Cirrito;Daniel W. Wesson;Daniel W. Wesson;C. Y. Daniel Lee

  • Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

    Kelvin C. Luk;Cheng Song;Patrick O'Brien;Anna Stieber

  • Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.

    Zhuohao He;Jing L Guo;Jennifer D McBride;Sneha Narasimhan

  • Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

    Kurt R. Brunden;John Q. Trojanowski;Virginia M.-Y. Lee

  • The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

    Bin Zhang;Jenna Carroll;John Q. Trojanowski;Yuemang Yao

  • Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia.

    Douglas R. McDonald;Kurt R. Brunden;Gary E. Landreth

  • Identification of a Novel Extracellular Cation-sensing G-protein-coupled Receptor

    Min Pi;Pieter Faber;George Ekema;P. David Jackson

  • Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

    Selcuk A. Tanik;Christine E. Schultheiss;Laura A. Volpicelli-Daley;Kurt R. Brunden

  • Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy.

    Jenna C. Carroll;Michiyo Iba;Debbie A. Bangasser;Rita J. Valentino

  • Evidence for glial-mediated inflammation in aged APPSW transgenic mice

    W. C. Benzing;J. R. Wujek;E. K. Ward;D. Shaffer

  • Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

    Kurt R. Brunden;Bin Zhang;Jenna Carroll;Yuemang Yao

  • Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia.

    Stephen L. Yates;Loyd H. Burgess;June Kocsis‐Angle;Joyce M. Antal

  • Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

    Carlo Ballatore;Kurt R. Brunden;Donna M. Huryn;John Q. Trojanowski

  • Structure Property Relationships of Carboxylic Acid Isosteres

    Pierrik Lassalas;Caroline Lasfargeas;Michael J. James

  • Amyloid β protein (Aβ) removal by neuroglial cells in culture

    Lillian M. Shaffer;Michael D. Dority;Rekha Gupta-Bansal;Robert C.A. Frederickson

  • GPRC6A Null Mice Exhibit Osteopenia, Feminization and Metabolic Syndrome

    Min Pi;Ling Chen;Min-Zhao Huang;Wenyu Zhu

  • Proteoglycan-mediated Inhibition of Aβ Proteolysis A POTENTIAL CAUSE OF SENILE PLAQUE ACCUMULATION

    Rekha Gupta-Bansal;Robert C.A. Frederickson;Kurt R. Brunden

  • Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

    Eve Peeraer;Astrid Bottelbergs;Kristof Van Kolen;Ilie-Cosmin Stancu

  • pH‐Dependent Binding of Synthetic β‐Amyloid Peptides to Glycosaminoglycans

    Kurt R. Brunden;Nancy J. Richter‐Cook;Nishith Chaturvedi;Robert C. A. Frederickson

  • The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies.

    Kurt R. Brunden;Yuemang Yao;Justin S. Potuzak;Nuria Ibarz Ferrer

Frequent Co-Authors

John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Amos B. Smith
Amos B. Smith University of Pennsylvania
Bin Zhang
Bin Zhang Icahn School of Medicine at Mount Sinai
Sharon X. Xie
Sharon X. Xie University of Pennsylvania
William A. Cramer
William A. Cramer Purdue University West Lafayette
Daniel W. Wesson
Daniel W. Wesson University of Florida
Diederik Moechars
Diederik Moechars Janssen (Belgium)
Gary E. Landreth
Gary E. Landreth Indiana University

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