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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
132
Citations
57813
World Ranking
383
National Ranking
26

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Eckhard Mandelkow is affiliated with the German Center for Neurodegenerative Diseases in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on several important subfields including Molecular Biology, Physiology, Neurology, Cellular and Molecular Neuroscience, and Cell Biology.

The scientist's work addresses key topics such as Alzheimer's disease research and treatments, Neuroscience and Neuropharmacology Research, RNA Research and Splicing, Prion Diseases and Protein Misfolding, Neuroinflammation and Neurodegeneration Mechanisms, Supramolecular Self-Assembly in Materials, and Amino Acid Enzymes and Metabolism.

Among recent papers, significant publications include:

  • A current view on Tau protein phosphorylation in Alzheimer's disease, 2021, Current Opinion in Neurobiology
  • Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS, 2024, Nature Medicine
  • Disease-Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates, 2020, Angewandte Chemie International Edition
  • Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates, 2022, The EMBO Journal
  • FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments, 2020, Molecular Neurodegeneration

Frequent coauthors collaborating with Mandelkow include:

  • Jacek Biernat (14 publications)
  • Senthilvelrajan Kaniyappan (11 publications)
  • Eva-Maria Mandelkow (11 publications)
  • Markus Zweckstetter (8 publications)
  • Susanne Wegmann (5 publications)

The scientist frequently publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Research Square (Research Square)
  • Angewandte Chemie International Edition
  • Journal of Biological Chemistry

Best Publications

  • Tau in physiology and pathology

    Yipeng Wang;Eckhard Mandelkow

  • Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure.

    M. von Bergen;P. Friedhoff;J. Biernat;J. Heberle

  • Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

    K. Stamer;R. Vogel;E. Thies;E. Mandelkow

  • MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

    Gerard Drewes;Andreas Ebneth;Ute Preuss;Eva-Maria Mandelkow

  • Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease

    A. Ebneth;R. Godemann;K. Stamer;S. Illenberger

  • Tau in Alzheimer's disease

    Eva-Maria Mandelkow;Eckhard Mandelkow

  • Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

    Eva-Maria Mandelkow;Eckhard Mandelkow

  • Tau protein liquid–liquid phase separation can initiate tau aggregation

    Susanne Wegmann;Bahareh Eftekharzadeh;Katharina Tepper;Katarzyna M Zoltowska

  • Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

    Susmitha Ambadipudi;Jacek Biernat;Dietmar Riedel;Eckhard Mandelkow

  • Domains of tau protein and interactions with microtubules.

    N. Gustke;B. Trinczek;J. Biernat;E.-M. Mandelkow

  • Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

    G Drewes;B Lichtenberg-Kraag;F Döring;E M Mandelkow

  • Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

    Hans Zempel;Edda Thies;Eckhard Mandelkow;Eva-Maria Mandelkow

  • Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

    Marco D Mukrasch;Stefan Bibow;Jegannath Korukottu;Sadasivam Jeganathan

  • Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau

    E.-M. Mandelkow;G. Drewes;J. Biernat;N. Gustke

  • RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

    T. Kampers;P. Friedhoff;J. Biernat;E.-M. Mandelkow

  • Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

    Yipeng Wang;Marta Martinez-Vicente;Ulrike Krüger;Susmita Kaushik

  • Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

    K. Baumann;E. M. Mandelkow;J. Biernat;Helen Piwnica-Worms

  • Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure.

    Martin von Bergen;Stefan Barghorn;Li Li;Alexander Marx

  • Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments.

    A Schneider;J Biernat;M von Bergen;E Mandelkow

  • Microtubules and microtubule-associated proteins

    Eckhard Mandelkow;Eva-Maria Mandelkow

Frequent Co-Authors

Eva-Maria Mandelkow
Eva-Maria Mandelkow German Center for Neurodegenerative Diseases
Jacek Biernat
Jacek Biernat German Center for Neurodegenerative Diseases
Markus Zweckstetter
Markus Zweckstetter German Center for Neurodegenerative Diseases
Martin von Bergen
Martin von Bergen Helmholtz Centre for Environmental Research
Christian Griesinger
Christian Griesinger Max Planck Society
Gerard Drewes
Gerard Drewes GlaxoSmithKline (United Kingdom)
Martin Blackledge
Martin Blackledge Grenoble Alpes University
Helmut E. Meyer
Helmut E. Meyer Ruhr University Bochum
Gabriele M. Rune
Gabriele M. Rune Universität Hamburg

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