World's Best Scientists 2026 revealed!
Christian Griesinger

Christian Griesinger

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Chemistry
Germany
2026

D-Index & Metrics

Chemistry

D-Index
102
Citations
44984
World Ranking
1141
National Ranking
86

Research.com Recognitions

  • 2026 - Research.com Chemistry in Germany Leader Award
  • 2025 - Research.com Chemistry in Germany Leader Award
  • 2022 - Research.com Chemistry in Germany Leader Award

Overview

Christian Griesinger is affiliated with the Max Planck Society in Germany and has contributed extensively to the fields of biochemistry, genetics, molecular biology, medicine, and chemistry. Their research spans several specialized subfields including molecular biology, spectroscopy, neurology, organic chemistry, and physiology.

The scientist's work centers on advanced nuclear magnetic resonance (NMR) techniques and applications, with significant focus on Alzheimer's disease research and treatments as well as Parkinson's disease mechanisms and treatments. Additional main topics include protein structure and dynamics, molecular spectroscopy and chirality, and advanced magnetic resonance imaging (MRI) techniques and applications.

Frequent coauthors collaborating with Christian Griesinger include:

  • Stefan Becker
  • Loren B. Andreas
  • Andrei Leonov
  • Sergey Ryazanov
  • Karin Giller

Christian Griesinger has published widely across several academic venues, with a notable number of papers appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Angewandte Chemie
  • FEBS Letters
  • Journal of the American Chemical Society

Representative recent publications include:

  • The 3D structure of lipidic fibrils of α-synuclein, 2022, Nature Communications
  • [11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates, 2020, European Journal of Nuclear Medicine and Molecular Imaging
  • Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial, 2022, EBioMedicine
  • Proton Detected Solid-State NMR of Membrane Proteins at 28 Tesla (1.2 GHz) and 100 kHz Magic-Angle Spinning, 2021, Biomolecules
  • Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes, 2021, Science Advances

Best Publications

  • Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

    Michael Sattler;Jürgen Schleucher;Christian Griesinger

  • Clean TOCSY for proton spin system identification in macromolecules

    C. Griesinger;G. Otting;K. Wuethrich;Richard R. Ernst

  • Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

    Oliver F. Lange;Nils Alexander Lakomek;Christophe Farès;Gunnar F. Schröder

  • A general enhancement scheme in heteronuclear multidimensional NMR employing pulsed field gradients.

    J. Schleucher;M. Schwendinger;M. Sattler;P. Schmidt

  • Release of long-range tertiary interactions potentiates aggregation of natively unstructured α-synuclein

    Carlos W. Bertoncini;Young-Sang Jung;Claudio O. Fernandez;Wolfgang Hoyer

  • Assignment of carbonyl carbons and sequence analysis in peptides by heteronuclear shift correlation via small coupling constants with broadband decoupling in t1 (COLOC)

    H Kessler;C Griesinger;J Zarbock;H.R Loosli

  • Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

    Marco D Mukrasch;Stefan Bibow;Jegannath Korukottu;Sadasivam Jeganathan

  • Structure of the human voltage-dependent anion channel

    Monika Bayrhuber;Thomas Meins;Michael Habeck;Stefan Becker

  • Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism.

    Aiman S. Saab;Iva D. Tzvetavona;Andrea Trevisiol;Selva Baltan

  • Two-Dimensional Correlation of Connected NMR Transitions.

    C. Griesinger;O. W. Soerensen;R. R. Ernst

  • Practical aspects of the E.COSY technique. Measurement of scalar spin-spin coupling constants in peptides

    C Griesinger;O.W Sørensen;R.R Ernst

  • Two‐Dimensional NMR Spectroscopy: Background and Overview of the Experiments [New Analytical Methods (36)]

    Horst Kessler;Matthias Gehrke;Christian Griesinger

  • Pre‐fibrillar α‐synuclein variants with impaired β‐structure increase neurotoxicity in Parkinson's disease models

    Damla Pinar Karpinar;Madhu Babu Gajula Balija;Sebastian Kügler;Felipe Opazo

  • Frequency offset effects and their elimination in NMR rotating-frame cross-relaxation spectroscopy

    C Griesinger;R.R Ernst

  • Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

    Rodolfo M. Rasia;Carlos W. Bertoncini;Derek Marsh;Wolfgang Hoyer

  • Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

    Jens Wagner;Sergey Ryazanov;Sergey Ryazanov;Andrei Leonov;Andrei Leonov;Johannes Levin

  • Transformation of homonuclear two-dimensional NMR techniques into one-dimensional techniques using Gaussian pulses

    H Kessler;H Oschkinat;C Griesinger;W Bermel

  • Separation of cross-relaxation and J cross-peaks in 2D rotating-frame NMR spectroscopy

    Horst Kessler;Christian Griesinger;Rainer Kerssebaum;Klaus Wagner

  • Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement.

    Andrés Binolfi;Rodolfo M. Rasia;Carlos W. Bertoncini;Marcelo Ceolin

  • Direct measurement of angles between bond vectors in high-resolution NMR.

    Bernd Reif;Mirko Hennig;Christian Griesinger

Frequent Co-Authors

Stefan Becker
Stefan Becker Max Planck Society
Markus Zweckstetter
Markus Zweckstetter German Center for Neurodegenerative Diseases
Harald Schwalbe
Harald Schwalbe Goethe University Frankfurt
Armin Giese
Armin Giese Ludwig-Maximilians-Universität München
Jens Meiler
Jens Meiler Vanderbilt University
Wolfgang Bermel
Wolfgang Bermel University of Florence
Horst Kessler
Horst Kessler Technical University of Munich
Bert L. de Groot
Bert L. de Groot Max Planck Society
Bernd Reif
Bernd Reif Technical University of Munich
Adam Lange
Adam Lange Humboldt-Universität zu Berlin

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