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Biology and Biochemistry

D-Index
45
Citations
19394
World Ranking
19027
National Ranking
612

Overview

Marta Muzio is affiliated with Vita-Salute San Raffaele University in Italy and has contributed extensively to the field of medicine, with a particular focus on genetics, molecular biology, immunology, oncology, and public health. Their research portfolio includes 14 publications across these disciplines, emphasizing the molecular and cellular mechanisms underpinning chronic lymphocytic leukemia and related hematological malignancies.

The scientist's recent scholarly output includes several papers published between 2020 and 2024. These include:

  • Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death (2024, Cell Death and Disease)
  • Interleukin-1 receptor-associated kinase 4 inhibitor interrupts toll-like receptor signalling and sensitizes chronic lymphocytic leukaemia cells to apoptosis (2020, British Journal of Haematology)
  • Role of NFAT in Chronic Lymphocytic Leukemia and Other B-Cell Malignancies (2021, Frontiers in Oncology)
  • Dimethyl itaconate selectively targets inflammatory and metabolic pathways in chronic lymphocytic leukemia (2023, European Journal of Immunology)
  • SIGIRR Downregulation and Interleukin-1 Signaling Intrinsic to Renal Cell Carcinoma (2022, Frontiers in Oncology)

The contributions span topics such as chronic lymphocytic leukemia research, cancer immunotherapy and biomarkers, acute lymphoblastic leukemia research, immune cell function and interaction, lymphoma diagnosis and treatment, genomics, phytochemicals and oxidative stress, and PI3K/AKT/mTOR signaling in cancer.

Frequent coauthors collaborating with Marta Muzio include:

  • Maria Elena Mantione
  • Ilenia Sana
  • Michela Riba
  • Paolo Ghia
  • Miriam Meloni

Their publications have appeared predominantly in venues such as the European Journal of Immunology, Frontiers in Oncology, Zenodo at CERN, Cell Death and Disease, and the British Journal of Haematology. Among these, the European Journal of Immunology and Frontiers in Oncology are recurring platforms hosting multiple of their studies.

Marta Muzio's investigative work revolves primarily around understanding mechanisms of leukemic cell survival, inflammatory signaling pathways, and molecular targets for potential therapeutic intervention. The research articulates a focus on chronic lymphocytic leukemia and other B-cell malignancies, evaluating the sensitivity of cancer cells to apoptosis through modulation of immune and metabolic pathways.

Best Publications

  • FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.

    Marta Muzio;Arul M. Chinnaiyan;Frank C. Kischkel;Karen O'Rourke

  • An Induced Proximity Model for Caspase-8 Activation

    Marta Muzio;Brent R. Stockwell;Henning R. Stennicke;Guy S. Salvesen

  • Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells.

    M. Muzio;D. Bosisio;N. Polentarutti;G. D'amico

  • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

    Marta Muzio;Jian Ni;Jian Ni;Ping Feng;Ping Feng;Vishva M. Dixit;Vishva M. Dixit

  • Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4

    Francesco Colotta;Fabio Re;Marta Muzio;Riccardo Bertini

  • Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells DIFFERENTIAL EXPRESSION OF TLR-4 AND TLR-2 IN ENDOTHELIAL CELLS

    Emmanuelle Faure;Ozlem Equils;Peter A. Sieling;Lisa Thomas

  • The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

    Marta Muzio;Gioacchino Natoli;Simona Saccani;Massimo Levrero

  • Bacterial Lipopolysaccharide Activates Nuclear Factor-κB through Interleukin-1 Signaling Mediators in Cultured Human Dermal Endothelial Cells and Mononuclear Phagocytes

    Frank X. Zhang;Carsten J. Kirschning;Roberta Mancinelli;Xiao Ping Xu

  • Target Protease Specificity of the Viral Serpin CrmA ANALYSIS OF FIVE CASPASES

    Qiao Zhou;Scott Snipas;Kim Orth;Marta Muzio

  • Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c

    Tomomi Kuwana;Jesse J. Smith;Marta Muzio;Vishva Dixit

  • FLICE Induced Apoptosis in a Cell-free System CLEAVAGE OF CASPASE ZYMOGENS

    Marta Muzio;Guy S. Salvesen;Vishva M. Dixit

  • Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: A molecular basis for priming and synergism with bacterial lipopolysaccharide

    Daniela Bosisio;Nadia Polentarutti;Marina Sironi;Sergio Bernasconi

  • Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family

    Cecilia Garlanda;Federica Riva;Nadia Polentarutti;Chiara Buracchi

  • Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy

    Marta Muzio;Benedetta Apollonio;Cristina Scielzo;Michela Frenquelli

  • Toll-like receptor family and signalling pathway.

    M. Muzio;N. Polentarutti;Daniela Bosisio;P. P. Manoj Kumar

  • The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor.

    F Re;M Muzio;M De Rossi;N Polentarutti

  • Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes.

    Marta Muzio;Nadia Polentarutti;Daniela Bosisio;Manoj Kumar Panatt Prahladan

  • Micrococci and Peptidoglycan Activate TLR2→MyD88→IRAK→TRAF→NIK→IKK→NF-κB Signal Transduction Pathway That Induces Transcription of Interleukin-8

    Qiuling Wang;Roman Dziarski;Carsten J. Kirschning;Marta Muzio

  • Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist.

    M Muzio;N Polentarutti;M Sironi;G Poli

  • Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.

    Nadia Polentarutti;Giselle Penton Rol;Marta Muzio;Daniela Bosisio

Frequent Co-Authors

Paolo Ghia
Paolo Ghia Vita-Salute San Raffaele University
Federico Caligaris-Cappio
Federico Caligaris-Cappio Vita-Salute San Raffaele University
Alberto Mantovani
Alberto Mantovani Humanitas University
Nadia Polentarutti
Nadia Polentarutti Humanitas University
Francesco Colotta
Francesco Colotta Mario Negri Institute for Pharmacological Research
Kostas Stamatopoulos
Kostas Stamatopoulos Centre for Research and Technology Hellas
Martino Introna
Martino Introna Mario Negri Institute for Pharmacological Research
Marina Sironi
Marina Sironi Humanitas University
Cecilia Garlanda
Cecilia Garlanda Humanitas University

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