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Biology and Biochemistry

D-Index
136
Citations
111511
World Ranking
331
National Ranking
223

Overview

Guy S. Salvesen is affiliated with the Sanford Burnham Prebys Medical Discovery Institute in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with a notable focus on molecular biology and immunology as subfields.

Their scholarly work addresses a variety of topics including inflammasome and immune disorders, cell death mechanisms and regulation, RNA interference and gene delivery, interferon and immune responses, protease and inhibitor mechanisms, advanced biosensing and bioanalysis techniques, and peptidase inhibition and analysis.

Salvesen's publication record includes contributions to the following frequent venues:

  • Journal of Biological Chemistry
  • UNC Libraries
  • Nature Communications
  • Biochemical Journal
  • FEBS Journal

Some recent papers authored or coauthored by Salvesen include:

  • The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins: EVOLUTION, MECHANISM OF INHIBITION, NOVEL FUNCTIONS, AND A REVISED NOMENCLATURE (2021, UNC Libraries)
  • Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11 (2020, Journal of Biological Chemistry)
  • Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy (2020, Proceedings of the National Academy of Sciences)
  • Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion (2020, Nature Communications)
  • Caspase mechanisms in the regulation of inflammation (2022, Molecular Aspects of Medicine)

Salvesen frequently collaborates with other researchers. Notable coauthors include:

  • Scott J. Snipas
  • Marcin Drąg
  • Betsaida Bibo-Verdugo
  • Sonia Kołt
  • Marcin Poręba

The scientist's research contributes to several core fields and topics that bridge molecular biology and clinical medicine, focusing on inflammation regulation, protease activity, and mechanisms governing cell death, which are essential for understanding immune disorders and therapeutic development.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

    Warren J. Strittmatter;Ann M. Saunders;Donald Schmechel;Margaret Pericak-Vance

  • Regulation of Cell Death Protease Caspase-9 by Phosphorylation

    Michael H. Cardone;Natalie Roy;Henning R. Stennicke;Guy S. Salvesen

  • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

    Nobuhiko Kayagaki;Irma B. Stowe;Bettina L. Lee;Karen O’Rourke

  • Human ICE/CED-3 Protease Nomenclature

    Emad S Alnemri;David J Livingston;Donald W Nicholson;Guy Salvesen

  • Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

    Muneesh Tewari;Long T Quan;Karen O'Rourke;Serge Desnoyers

  • CASPASES : INTRACELLULAR SIGNALING BY PROTEOLYSIS

    Guy S Salvesen;Vishva M Dixit

  • X-linked IAP is a direct inhibitor of cell-death proteases

    Quinn L. Deveraux;Ryosuke Takahashi;Guy S. Salvesen;John C. Reed

  • IAP proteins: blocking the road to death's door

    Guy S. Salvesen;Colin S. Duckett

  • Human plasma proteinase inhibitors

    J Travis;G S Salvesen

  • IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases

    Quinn L. Deveraux;Natalie Roy;Henning R. Stennicke;Todd Van Arsdale

  • Mechanisms of caspase activation.

    Kelly M Boatright;Guy S Salvesen

  • Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

    Warren J. Strittmatter;Karl H. Weisgraber;David Y. Huang;Li Ming Dong

  • The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases

    Natalie Roy;Quinn L. Deveraux;Ryosuke Takahashi;Guy S. Salvesen

  • The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

    Gary A. Silverman;Phillip I. Bird;Robin W. Carrell;Frank C. Church

  • An Induced Proximity Model for Caspase-8 Activation

    Marta Muzio;Brent R. Stockwell;Henning R. Stennicke;Guy S. Salvesen

  • The apoptosome: signalling platform of cell death

    Stefan J. Riedl;Guy S. Salvesen

  • Viral inhibition of inflammation. Cowpox virus encodes an inhibitor of the interleukin 1β converting enzyme.

    Caroline A. Ray;Roy A. Black;Shirley R. Kronheim;Teresa A. Greenstreet

  • A unified model for apical caspase activation.

    Kelly M Boatright;Martin Renatus;Fiona L Scott;Sabina Sperandio

  • Caspase activation: the induced-proximity model.

    Guy S. Salvesen;Vishva M. Dixit

Frequent Co-Authors

Marcin Drag
Marcin Drag Wrocław University of Science and Technology
Jan J. Enghild
Jan J. Enghild Aarhus University
John C. Reed
John C. Reed Johnson & Johnson (United States)
Boris Turk
Boris Turk Jožef Stefan Institute
Salvatore V. Pizzo
Salvatore V. Pizzo Duke University
Dale E. Bredesen
Dale E. Bredesen University of California, Los Angeles
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
James Travis
James Travis University of Georgia
Matthew Bogyo
Matthew Bogyo Stanford University

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