World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
99
Citations
35712
World Ranking
752
National Ranking
428

Medicine

D-Index
100
Citations
41561
World Ranking
8218
National Ranking
4258

Overview

George F. Murphy is affiliated with Brigham and Women's Hospital in the United States. Their research focuses primarily on immunology, with significant contributions spanning immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. The scientist's work also intersects with subfields including immunology, oncology, dermatology, genetics, and molecular biology.

Murphy's recent scholarly output includes several papers published in prominent journals. These works explore various aspects of immune regulation, tolerance, and dysfunction. Notable publications include:

  • PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance (2020, The Journal of Experimental Medicine)
  • Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3 (2022, Nature Immunology)
  • Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency (2024, Journal of Allergy and Clinical Immunology)
  • Human skin rejuvenation via mRNA (2024, bioRxiv [Cold Spring Harbor Laboratory])
  • S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis (2025, Immunity)

The scientist's frequent co-authors include Qianxia Zhang, Christine G. Lian, Dario A.A. Vignali, Mrinmoy Das, and Brian Woods, each of whom has collaborated with Murphy on multiple research projects.

Murphy has published across several renowned venues, reflecting the varied scope of their research interests. These publication venues are:

  • The Journal of Experimental Medicine
  • Nature Immunology
  • Journal of Allergy and Clinical Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Immunity

The core research topics encompassed in Murphy's work include:

  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Cancer Immunotherapy and Biomarkers
  • Immunodeficiency and Autoimmune Disorders
  • Diabetes and associated disorders
  • Skin Protection and Aging
  • Single-cell and spatial transcriptomics

The research covers in-depth investigation into immune cell regulation, including the roles of regulatory T cells and exhaustion-like programs in restraining autoreactivity. There is also a notable focus on skin-related immune responses, such as eczema linked to genetic deficiencies and skin rejuvenation via mRNA technologies. Murphy's work also extends into cancer immunotherapy and mechanisms underlying immune tolerance and dysfunction.

Best Publications

  • Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

    Itay Tirosh;Benjamin Izar;Benjamin Izar;Sanjay M. Prakadan;Marc H. Wadsworth

  • Identification of cells initiating human melanomas

    Tobias Schatton;George F. Murphy;Natasha Y. Frank;Kazuhiro Yamaura

  • Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin.

    I. V. Yannas;Edward Y. Lee;Dennis Paul Orgill;E. M. Skrabut

  • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma

    Dennie Tompers Frederick;Adriano Piris;Alexandria P. Cogdill;Zachary A. Cooper

  • Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

    Christine Guo Lian;Yufei Xu;Craig Ceol;Craig Ceol;Feizhen Wu

  • Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1.

    Laurence J. Walsh;Giorgio Trinchieri;Heidi A. Waldorf;Diana Whitaker

  • Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide

    J Hosoi;G F Murphy;C L Egan;E A Lerner

  • Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth

    Sonja Kleffel;Christian Posch;Steven R Barthel;Hansgeorg Mueller;Hansgeorg Mueller

  • Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.

    Alan M. Hanash;Jarrod A. Dudakov;Guoqiang Hua;Margaret H. O’Connor

  • Bevacizumab plus Ipilimumab in Patients with Metastatic Melanoma

    F. Stephen Hodi;Donald Lawrence;Cecilia Lezcano;Xinqi Wu

  • Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

    Yusuke Shono;Melissa D. Docampo;Jonathan U. Peled;Jonathan U. Peled;Suelen M. Perobelli

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris

    Peter J. Koch;M G. Mahoney;Hiroyasu Ishikawa;Leena Pulkkinen

  • Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

    Di Wu;Di Wu;Di Hu;Di Hu;Hao Chen;Hao Chen;Guoming Shi;Guoming Shi

  • Effects of α-hydroxy acids on photoaged skin: Apilot clinical, histologic, and ultrastructural study

    Chérie M. Ditre;Thomas D. Griffin;George F. Murphy;Hirohiko Sueki

  • Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women's Hospital Tumor Staging for Cutaneous Squamous Cell Carcinoma

    Pritesh S. Karia;Anokhi Jambusaria-Pahlajani;David P. Harrington;George F. Murphy

  • Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial.

    Alain H. Rook;Bruce Freundlich;Brian V. Jegasothy;Maritza I. Perez

  • Resident Memory T Cells (TRM) Are Abundant in Human Lung: Diversity, Function, and Antigen Specificity

    Rahul Purwar;James Campbell;George Murphy;William G. Richards

  • Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion

    Lynn M. Klein;Robert M. Lavker;Wendy L. Matis;George F. Murphy

  • Modulation of T-Cell Activation by Malignant Melanoma Initiating Cells

    Tobias Schatton;Ute Schütte;Natasha Y. Frank;Qian Zhan

  • Melanosomes are a primary target of Q-switched ruby laser irradiation in guinea pig skin.

    Luigi L. Polla;Randall J. Margolis;Jeffrey S. Dover;Diana Whitaker

  • Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

    I. Tirosh;B. Izar;D. Treacy;J. J. Trombetta

Frequent Co-Authors

Martin C. Mihm
Martin C. Mihm Brigham and Women's Hospital
Marcel R.M. van den Brink
Marcel R.M. van den Brink Memorial Sloan Kettering Cancer Center
Chen Liu
Chen Liu Yale University
Robert Korngold
Robert Korngold Hackensack University Medical Center
Thomas S. Kupper
Thomas S. Kupper Brigham and Women's Hospital
Robert R. Jenq
Robert R. Jenq The University of Texas MD Anderson Cancer Center
Dennis P. Orgill
Dennis P. Orgill Brigham and Women's Hospital
Diana Whitaker-Menezes
Diana Whitaker-Menezes Thomas Jefferson University
Atul K. Bhan
Atul K. Bhan Harvard University
Steven M. Albelda
Steven M. Albelda University of Pennsylvania

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