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Biology and Biochemistry

D-Index
152
Citations
87492
World Ranking
166
National Ranking
115

Medicine

D-Index
152
Citations
87663
World Ranking
1077
National Ranking
619

Overview

Meenhard Herlyn is affiliated with The Wistar Institute in the United States. Their research encompasses several fields centered on cancer biology, with a primary focus on biochemistry, genetics, molecular biology, and medicine. Specifically, their work spans molecular biology, oncology, immunology, cancer research, and cell biology.

Herlyn's research covers multiple topics within these fields, including:

  • Melanoma and MAPK Pathways
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • Single-cell and spatial transcriptomics
  • Cutaneous Melanoma Detection and Management

Their work is published frequently in venues known for cancer and biomedical research, including:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature
  • Clinical Cancer Research

Frequent collaborators in their research include Vito W. Rebecca, Xiaowei Xu, Michael A. Davies, Yeqing Chen, and Keith T. Flaherty.

Selected recent papers from Meenhard Herlyn show a focus on melanoma and cancer modeling, often addressing therapy resistance, tumor microenvironment, and genomic profiling. Notable recent publications include:

  • Pre-clinical modeling of cutaneous melanoma, 2020, Nature Communications
  • Melanoma models for the next generation of therapies, 2021, Cancer Cell
  • Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts, 2021, Nature Genetics
  • Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy, 2021, Nature Communications
  • Stromal changes in the aged lung induce an emergence from melanoma dormancy, 2022, Nature

Best Publications

  • Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response

    Gang Chen;Alexander C. Huang;Wei Zhang;Wei Zhang;Gao Zhang

  • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

    Vassilis G. Gorgoulis;Leandros-Vassilios F. Vassiliou;Panagiotis Karakaidos;Panayotis Zacharatos

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Colorectal carcinoma antigens detected by hybridoma antibodies

    Hilary Koprowski;Zenon Steplewski;Kenneth Mitchell;Meenhard Herlyn

  • A tumorigenic subpopulation with stem cell properties in melanomas.

    Dong Fang;Thiennga K. Nguyen;Kim Leishear;Rena Finko

  • Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

    James Tsai;John T. Lee;Weiru Wang;Jiazhong Zhang

  • Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

    Jessie Villanueva;Adina Vultur;John T. Lee;Rajasekharan Somasundaram

  • BRAF and RAS mutations in human lung cancer and melanoma

    Marcia S. Brose;Patricia Volpe;Michael Feldman;Madhu Kumar

  • A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

    Livnat Jerby-Arnon;Parin Shah;Michael S. Cuoco;Christopher Rodman

  • A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

    Alexander Roesch;Mizuho Fukunaga-Kalabis;Elizabeth C. Schmidt;Susan E. Zabierowski

  • High-throughput oncogene mutation profiling in human cancer

    Roman K. Thomas;Alissa C. Baker;Ralph M. DeBiasi;Ralph M. DeBiasi;Wendy Winckler;Wendy Winckler

  • Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression

    Steven M. Albelda;Stephen A. Mette;David E. Elder;RoseMary Stewart

  • Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

    Sydney M. Shaffer;Margaret C. Dunagin;Stefan R. Torborg;Eduardo A. Torre

  • Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies

    Meenhard Herlyn;Zenon Steplewski;Dorothee Herlyn;Hilary Koprowski

  • Axis of evil: molecular mechanisms of cancer metastasis.

    Thomas Bogenrieder;Meenhard Herlyn

  • Specific antigen in serum of patients with colon carcinoma

    Hilary Koprowski;Meenhard Herlyn;Zenon Steplewski;Henry F. Sears

  • Regulation of Notch1 and Dll4 by Vascular Endothelial Growth Factor in Arterial Endothelial Cells: Implications for Modulating Arteriogenesis and Angiogenesis

    Zhao Jun Liu;Takashi Shirakawa;Yan Li;Akinobu Soma

  • Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

    Alexander Roesch;Adina Vultur;Ivan Bogeski;Huan Wang

  • Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

    Lin Yang;Han C. Dan;Mei Sun;Qiyuan Liu

  • Activation of the DNA damage checkpointandgenomicinstabilityin human precancerous lesions

    Vassilis G. Gorgoulis;Leandros-Vassilios F. Vassiliou;Panagiotis Karakaidos;Panayotis Zacharatos

Frequent Co-Authors

Xiaowei Xu
Xiaowei Xu University of Pennsylvania
Keith T. Flaherty
Keith T. Flaherty Harvard University
Nikolas K. Haass
Nikolas K. Haass University of Queensland
Kapaettu Satyamoorthy
Kapaettu Satyamoorthy Manipal University Jaipur
David E. Elder
David E. Elder Hospital of the University of Pennsylvania
Dorothee Herlyn
Dorothee Herlyn The Wistar Institute
Ulrich Rodeck
Ulrich Rodeck Thomas Jefferson University
Katherine L. Nathanson
Katherine L. Nathanson University of Pennsylvania
Hilary Koprowski
Hilary Koprowski Thomas Jefferson University
Anil K. Rustgi
Anil K. Rustgi Columbia University

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