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Medicine

D-Index
93
Citations
39458
World Ranking
10748
National Ranking
5526

Overview

Xiaowei Xu is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of medicine, biochemistry, genetics and molecular biology, and immunology and microbiology. Within these domains, Xiaowei Xu has contributed extensively to oncology, immunology, molecular biology, cell biology, and hematology.

The scientist's work focuses on several key topics including cancer immunotherapy and biomarkers, immunotherapy and immune responses, CAR-T cell therapy research, cutaneous melanoma detection and management, immune cell function and interaction, melanoma and MAPK pathways, and hematopoietic stem cell transplantation.

Frequent co-authors collaborating with Xiaowei Xu include Giorgos C. Karakousis, Tara C. Mitchell, Ravi K. Amaravadi, Lynn M. Schuchter, and Alexander C. Huang.

Publications by Xiaowei Xu appear regularly in several prominent scientific journals. The most frequent publication venues are Nature Communications and Cancer Research with six publications each, followed by Journal of Clinical Oncology and Annals of Surgical Oncology with five publications each, and Cell Reports with four publications.

Some recent papers authored or co-authored by Xiaowei Xu include:

  • Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms, 2020, Immunity
  • Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC), 2021, Nature Medicine
  • ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis, 2020, Cancer Cell
  • Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics, 2022, Nature Immunology
  • Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy, 2021, Nature Communications

Best Publications

  • Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response

    Gang Chen;Alexander C. Huang;Wei Zhang;Wei Zhang;Gao Zhang

  • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

    Christina Twyman-Saint Victor;Andrew J. Rech;Amit Maity;Ramesh Rengan;Ramesh Rengan

  • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma

    Gideon Bollag;Peter Hirth;James Tsai;Jiazhong Zhang

  • A tumorigenic subpopulation with stem cell properties in melanomas.

    Dong Fang;Thiennga K. Nguyen;Kim Leishear;Rena Finko

  • T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

    Alexander C. Huang;Michael A. Postow;Michael A. Postow;Robert J. Orlowski;Rosemarie Mick

  • TOX transcriptionally and epigenetically programs CD8 + T cell exhaustion

    Omar Khan;Josephine R. Giles;Sierra McDonald;Sasikanth Manne

  • Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

    Jessie Villanueva;Adina Vultur;John T. Lee;Rajasekharan Somasundaram

  • Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

    Jean-Christophe Beltra;Sasikanth Manne;Mohamed S. Abdel-Hakeem;Makoto Kurachi

  • Phase II, Open-Label, Single-Arm Trial of Imatinib Mesylate in Patients With Metastatic Melanoma Harboring c-Kit Mutation or Amplification

    Jun Guo;Lu Si;Yan Kong;Keith T. Flaherty

  • Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients

    Thomas Condamine;George A. Dominguez;Je-In Youn;Andrew V. Kossenkov

  • Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors

    Vinit Kumar;Laxminarasimha Donthireddy;Douglas Marvel;Thomas Condamine

  • Enhancing CD8 + T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.

    Ying Zhang;Ying Zhang;Raj Kurupati;Ling Liu;Xiang Yang Zhou

  • A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma

    Alexander C. Huang;Robert J. Orlowski;Robert J. Orlowski;Xiaowei Xu;Rosemarie Mick

  • Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

    Xiao Hong Ma;Sheng Fu Piao;Souvik Dey;Quentin McAfee

  • Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles

    Hong Yu;Dong Fang;Suresh M. Kumar;Ling Li

  • sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

    Amanpreet Kaur;Amanpreet Kaur;Marie R. Webster;Katie Marchbank;Reeti Behera

  • Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation

    Suresh M. Kumar;Shujing Liu;Hezhe Lu;Hongtao Zhang

  • CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

    Vinit Kumar;Pingyan Cheng;Thomas Condamine;Sridevi Mony

  • Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

    Amanpreet Kaur;Amanpreet Kaur;Amanpreet Kaur;Brett L. Ecker;Stephen M. Douglass;Curtis H. Kugel

  • Evaluation of AJCC Tumor Staging for Cutaneous Squamous Cell Carcinoma and a Proposed Alternative Tumor Staging System

    Anokhi Jambusaria-Pahlajani;Peter A. Kanetsky;Pritesh S. Karia;Wei Ting Hwang

Frequent Co-Authors

Lynn M. Schuchter
Lynn M. Schuchter University of Pennsylvania
David E. Elder
David E. Elder Hospital of the University of Pennsylvania
Ravi K. Amaravadi
Ravi K. Amaravadi University of Pennsylvania
Meenhard Herlyn
Meenhard Herlyn The Wistar Institute
Phyllis A. Gimotty
Phyllis A. Gimotty University of Pennsylvania
Keith T. Flaherty
Keith T. Flaherty Harvard University
Ashani T. Weeraratna
Ashani T. Weeraratna Johns Hopkins University
Katherine L. Nathanson
Katherine L. Nathanson University of Pennsylvania
Wei Xu
Wei Xu Shenzhen University
David W. Speicher
David W. Speicher The Wistar Institute

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