World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
19654
World Ranking
9014
National Ranking
4006

Overview

Ashani T. Weeraratna is affiliated with Johns Hopkins University in the United States and has a strong presence in the fields of biochemistry, genetics, molecular biology, and medicine. Their research activity spans several subfields, including molecular biology, oncology, immunology, cancer research, and cell biology.

The scientist's work covers various main research topics such as cancer cells and metastasis, immunotherapy and immune responses, cancer immunotherapy and biomarkers, immune cells in cancer, cell adhesion molecules research, CAR-T cell therapy research, and melanoma and MAPK pathways.

They have contributed to multiple recent papers, which include:

  • A framework for advancing our understanding of cancer-associated fibroblasts, 2020, Nature Reviews. Cancer
  • Fibroblasts in cancer: Unity in heterogeneity, 2023, Cell
  • Embracing cancer complexity: Hallmarks of systemic disease, 2024, Cell
  • Melanoma models for the next generation of therapies, 2021, Cancer Cell
  • Stromal changes in the aged lung induce an emergence from melanoma dormancy, 2022, Nature

Their frequent coauthors include Mitchell E. Fane, Yash Chhabra, Daniel J. Zabransky, Alexis E. Carey, and Vania Wang.

Weeraratna publishes often in venues such as Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Trends in Cell Biology, Nature, and Clinical Cancer Research. Among these, Cancer Research stands out as the most frequent venue with 34 publications.

In addition to journal articles, Weeraratna has published books with Johns Hopkins University Press, including the 2021 title Is Cancer Inevitable?

Best Publications

  • A framework for advancing our understanding of cancer-associated fibroblasts

    Erik Sahai;Igor Astsaturov;Edna Cukierman;David G. DeNardo

  • Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma.

    Ashani T. Weeraratna;Yuan Jiang;Galen Hostetter;Kevin Rosenblatt

  • Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors

    Vinit Kumar;Laxminarasimha Donthireddy;Douglas Marvel;Thomas Condamine

  • How the ageing microenvironment influences tumour progression

    Mitchell Fane;Ashani T. Weeraratna;Ashani T. Weeraratna

  • Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells

    Cheryl A. Sherman-Baust;Ashani T. Weeraratna;Leticia B.A. Rangel;Ellen S. Pizer

  • AGEMAP: a gene expression database for aging in mice.

    Jacob M Zahn;Suresh Poosala;Art B Owen;Donald K Ingram

  • The Wnt5A/Protein Kinase C Pathway Mediates Motility in Melanoma Cells via the Inhibition of Metastasis Suppressors and Initiation of an Epithelial to Mesenchymal Transition

    Samudra K. Dissanayake;Michael Wade;Carrie E. Johnson;Michael P. O'Connell

  • Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.

    Fadwa A. Attiga;Patricia M. Fernandez;Ashani T. Weeraratna;Michael J. Manyak

  • sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

    Amanpreet Kaur;Amanpreet Kaur;Marie R. Webster;Katie Marchbank;Reeti Behera

  • Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations

    Curtis H. Kugel;Stephen M. Douglass;Marie R. Webster;Amanpreet Kaur;Amanpreet Kaur

  • Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

    Amanpreet Kaur;Amanpreet Kaur;Amanpreet Kaur;Brett L. Ecker;Stephen M. Douglass;Curtis H. Kugel

  • Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

    Gao Zhang;Dennie T. Frederick;Lawrence Wu;Zhi Wei

  • Ghrelin promotes thymopoiesis during aging

    Vishwa Deep Dixit;Hyunwon Yang;Hyunwon Yang;Yuxiang Sun;Ashani T. Weeraratna

  • Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2

    Michael P O'Connell;Katie Marchbank;Marie R Webster;Alexander A Valiga

  • The Orphan Tyrosine Kinase Receptor, ROR2, Mediates Wnt5A Signaling in Metastatic Melanoma

    Michael P. O’Connell;Jennifer L. Fiori;Mai Xu;Arnell D. Carter

  • Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

    Zandra E. Walton;Chirag H. Patel;Rebekah C. Brooks;Yongjun Yu

  • PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

    M. Cecilia Caino;Jagadish C. Ghosh;Young Chan Chae;Valentina Vaira

  • Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

    M. Cecilia Caino;Young Chan Chae;Valentina Vaira;Stefano Ferrero

  • Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion

    Hossein Ahmadzadeh;Marie R. Webster;Reeti Behera;Angela M. Jimenez Valencia

  • Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

    Lavanya H Palavalli;Todd D Prickett;John R Wunderlich;Xiaomu Wei

Frequent Co-Authors

Dennis D. Taub
Dennis D. Taub George Washington University
Xiaowei Xu
Xiaowei Xu University of Pennsylvania
Meenhard Herlyn
Meenhard Herlyn The Wistar Institute
Andrew V. Kossenkov
Andrew V. Kossenkov The Wistar Institute
Kevin G. Becker
Kevin G. Becker National Institutes of Health
Maureen E. Murphy
Maureen E. Murphy The Wistar Institute
Keith T. Flaherty
Keith T. Flaherty Harvard University
Lynn M. Schuchter
Lynn M. Schuchter University of Pennsylvania
David W. Speicher
David W. Speicher The Wistar Institute
Dennie T. Frederick
Dennie T. Frederick Broad Institute

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