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Dennie T. Frederick

Dennie T. Frederick

Award Badge
Rising Stars
2025

D-Index & Metrics

Rising Stars

D-Index
63
Citations
30617
World Ranking
134
National Ranking
17

Biology and Biochemistry

D-Index
67
Citations
32194
World Ranking
8038
National Ranking
3645

Research.com Recognitions

  • 2025 - Research.com Rising Stars Award

Overview

Dennie T. Frederick is affiliated with the Broad Institute in the United States. Their research spans several domains within the biological and medical sciences, with a focus on cancer and immunology. The primary fields of study in their work include Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Within these broad areas, their subfields of study notably cover Oncology, Molecular Biology, Immunology, Cancer Research, and Radiology, Nuclear Medicine and Imaging.

Their scientific contributions concentrate on several main topics:

  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Cancer Genomics and Diagnostics
  • CAR-T cell therapy research
  • Melanoma and MAPK Pathways
  • Single-cell and spatial transcriptomics
  • Vaccines and immunoinformatics approaches

Dennie T. Frederick has published extensively, with notable papers including:

  • Spatially organized multicellular immune hubs in human colorectal cancer, 2021, Cell
  • Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma, 2021, Nature
  • Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring, 2020, Nature Medicine
  • In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer, 2022, Nature Immunology
  • Landscape of helper and regulatory antitumour CD4+ T cells in melanoma, 2022, Nature

The frequent co-authors collaborating with Dennie T. Frederick include:

  • Genevieve M. Boland
  • Keith T. Flaherty
  • Ryan J. Sullivan
  • Tatyana Sharova
  • Nir Hacohen

Typical publication venues for their research work are:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Oncology
  • Nature Communications
  • Nature

Best Publications

  • Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

    Itay Tirosh;Benjamin Izar;Benjamin Izar;Sanjay M. Prakadan;Marc H. Wadsworth

  • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

    Ravid Straussman;Teppei Morikawa;Kevin Shee;Michal Barzily-Rokni

  • Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.

    Leore T. Geller;Michal Barzily-Rokni;Tal Danino;Oliver H. Jonas;Oliver H. Jonas

  • Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma.

    Moshe Sade-Feldman;Moshe Sade-Feldman;Keren Yizhak;Stacey L. Bjorgaard;Stacey L. Bjorgaard;John P. Ray

  • A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

    Livnat Jerby-Arnon;Parin Shah;Michael S. Cuoco;Christopher Rodman

  • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma

    Dennie Tompers Frederick;Adriano Piris;Alexandria P. Cogdill;Zachary A. Cooper

  • Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

    Rizwan Haq;Jonathan Shoag;Pedro Andreu-Perez;Satoru Yokoyama;Satoru Yokoyama

  • Resistance to checkpoint blockade therapy through inactivation of antigen presentation.

    Moshe Sade-Feldman;Moshe Sade-Feldman;Yunxin J. Jiao;Yunxin J. Jiao;Jonathan H. Chen;Jonathan H. Chen;Michael S. Rooney

  • Spatially organized multicellular immune hubs in human colorectal cancer

    Karin Pelka;Matan Hofree;Jonathan H. Chen;Siranush Sarkizova

  • Toward Minimal Residual Disease-Directed Therapy in Melanoma.

    Florian Rambow;Aljosja Rogiers;Oskar Marin-Bejar;Sara Aibar

  • Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma

    Noam Auslander;Gao Zhang;Joo Sang Lee;Joo Sang Lee;Dennie T. Frederick

  • The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

    Luping Lin;Amit J Sabnis;Elton Chan;Victor Olivas

  • A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

    David J. Konieczkowski;Cory M. Johannessen;Omar Abudayyeh;Jong Wook Kim

  • Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy.

    Melvyn T. Chow;Aleksandra J. Ozga;Rachel L. Servis;Dennie T. Frederick

  • MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

    Nikhil Wagle;Nikhil Wagle;Eliezer M. Van Allen;Eliezer M. Van Allen;Daniel J. Treacy;Dennie T. Frederick

  • Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy

    Douglas B. Johnson;Monica V. Estrada;Roberto Salgado;Violeta Sanchez

  • A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

    Cory M. Johannessen;Laura A. Johnson;Laura A. Johnson;Laura A. Johnson;Federica Piccioni;Aisha Townes

  • Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade

    Douglas B. Johnson;Garrett M. Frampton;Matthew J. Rioth;Erik Yusko

  • BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.

    Chengwen Liu;Weiyi Peng;Chunyu Xu;Yanyan Lou

  • Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

    I. Tirosh;B. Izar;D. Treacy;J. J. Trombetta

Frequent Co-Authors

Keith T. Flaherty
Keith T. Flaherty Harvard University
Ryan J. Sullivan
Ryan J. Sullivan Harvard University
Jennifer A. Wargo
Jennifer A. Wargo The University of Texas MD Anderson Cancer Center
Nir Hacohen
Nir Hacohen Harvard University
Meenhard Herlyn
Meenhard Herlyn The Wistar Institute
Levi A. Garraway
Levi A. Garraway Roche (United States)
Xiaowei Xu
Xiaowei Xu University of Pennsylvania
Arlene H. Sharpe
Arlene H. Sharpe Harvard University
Lynn M. Schuchter
Lynn M. Schuchter University of Pennsylvania
David E. Fisher
David E. Fisher Harvard University

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