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Biology and Biochemistry

D-Index
51
Citations
10054
World Ranking
17122
National Ranking
1187

Overview

Jan Faix is affiliated with Hannover Medical School in Germany. Their research primarily focuses on cell biology, molecular mechanisms underlying cellular mechanics, and adhesion processes. The scientist's work spans the fields of biochemistry, genetics, molecular biology, and medicine, with particular emphasis on cell biology, biophysics, molecular biology, immunology and allergy, as well as cardiology and cardiovascular medicine.

Key topics explored in Jan Faix's research include cellular mechanics and interactions, cell adhesion molecules, cellular transport and secretion, advanced fluorescence microscopy techniques, skin and cellular biology, nuclear structure and function, and microtubule and mitosis dynamics.

Their recent publications emphasize the role of Ena/VASP proteins and cell protrusion dynamics. Notable papers authored or co-authored by Jan Faix are:

  • Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion (2020, eLife)
  • Ena/VASP proteins in cell edge protrusion, migration and adhesion (2022, Journal of Cell Science)
  • Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation (2020, Journal of Cell Science)
  • Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion (2021, Current Biology)
  • Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure (2022, Nature Communications)

Jan Faix collaborates frequently with other researchers, with the most prolific co-authors being:

  • Klemens Rottner
  • Sarah Körber
  • Thomas Pokrant
  • Theresia E. B. Stradal
  • Jonas Scholz

Their research findings are often published in specialized publication venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Science Advances
  • Journal of Cell Science
  • Current Biology

Best Publications

  • The making of filopodia

    Jan Faix;Klemens Rottner

  • Staying in Shape with Formins

    Jan Faix;Robert Grosse

  • Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

    Pirta Hotulainen;Olaya Llano;Sergei Smirnov;Kimmo Tanhuanpää

  • Arp2/3 complex interactions and actin network turnover in lamellipodia

    Frank P L Lai;Malgorzata Szczodrak;Jennifer Block;Jan Faix

  • The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia

    Antje Schirenbeck;Till Bretschneider;Rajesh Arasada;Michael Schleicher

  • Membrane Bending Modulus and Adhesion Energy of Wild-Type and Mutant Cells of Dictyostelium Lacking Talin or Cortexillins

    Rudolf Simson;Eva Wallraff;Jan Faix;Jens Niewöhner

  • Filopodia Formation in the Absence of Functional WAVE and Arp2/3 Complexes

    Anika Steffen;Jan Faix;Guenter P. Resch;Joern Linkner

  • A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system.

    Jan Faix;Lisa Kreppel;Gad Shaulsky;Michael Schleicher

  • Actin assembly mechanisms at a glance.

    Klemens Rottner;Jan Faix;Sven Bogdan;Stefan Linder

  • Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation

    Dennis Breitsprecher;Antje K Kiesewetter;Joern Linkner;Claus Urbanke

  • Inhibitory signalling to the Arp2/3 complex steers cell migration

    Irene Dang;Roman Gorelik;Carla Sousa-Blin;Emmanuel Derivery

  • Cortexillins, Major Determinants of Cell Shape and Size, Are Actin-Bundling Proteins with a Parallel Coiled-Coil Tail

    Jan Faix;Michel Steinmetz;Heike Boves;Richard A. Kammerer

  • FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

    Jennifer Block;Dennis Breitsprecher;Sonja Kühn;Moritz Winterhoff

  • The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation

    Antje Schirenbeck;Rajesh Arasada;Till Bretschneider;Theresia E. B. Stradal

  • Adhesion-induced receptor segregation and adhesion plaque formation: A model membrane study

    Annette Kloboucek;Almuth Behrisch;Jan Faix;Erich Sackmann

  • Filopodia: Complex models for simple rods.

    Jan Faix;Dennis Breitsprecher;Theresia E.B. Stradal;Klemens Rottner

  • Molecular mechanism of Ena/VASP-mediated actin-filament elongation

    Dennis Breitsprecher;Antje K Kiesewetter;Joern Linkner;Marlene Vinzenz

  • Cofilin cooperates with fascin to disassemble filopodial actin filaments.

    Dennis Breitsprecher;Stefan A. Koestler;Igor Chizhov;Maria Nemethova

  • A distinct 14 residue site triggers coiled‐coil formation in cortexillin I

    Michel O. Steinmetz;Alexander Stock;Therese Schulthess;Ruth Landwehr

  • Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation.

    Anika Steffen;Markus Ladwein;Georgi A. Dimchev;Anke Hein

Frequent Co-Authors

Klemens Rottner
Klemens Rottner Technische Universität Braunschweig
Theresia E. B. Stradal
Theresia E. B. Stradal Helmholtz Centre for Infection Research
Michael Schleicher
Michael Schleicher Ludwig-Maximilians-Universität München
Günther Gerisch
Günther Gerisch Max Planck Society
Angelika A. Noegel
Angelika A. Noegel University of Cologne
Laurent Blanchoin
Laurent Blanchoin Grenoble Alpes University
J. Victor Small
J. Victor Small Austrian Academy of Sciences
Michael Sixt
Michael Sixt Institute of Science and Technology Austria
Robert Geffers
Robert Geffers Helmholtz Centre for Infection Research
Michael Way
Michael Way The Francis Crick Institute

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