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Biology and Biochemistry
Italy
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
17246
World Ranking
6002
National Ranking
136

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Giorgio Scita is affiliated with the FIRC Institute of Molecular Oncology in Italy. Their research primarily focuses on biochemistry, genetics, and molecular biology with significant contributions to medicine. The scientist's work spans several subfields, notably cell biology, molecular biology, oncology, biomedical engineering, and physiology.

Scita's research covers a range of topics including:

  • Cellular mechanics and interactions
  • Cellular transport and secretion
  • 3D printing in biomedical research
  • Cancer cells and metastasis
  • Nuclear structure and function
  • Erythrocyte function and pathophysiology
  • Lipid membrane structure and behavior

Notable recent publications include:

  • "Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion," 2021, Cell
  • "Endocytosis in the context-dependent regulation of individual and collective cell properties," 2021, Nature Reviews Molecular Cell Biology
  • "ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration," 2020, Nature Communications
  • "Tissue fluidification promotes a cGAS-STING cytosolic DNA response in invasive breast cancer," 2022, Nature Materials
  • "Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis," 2021, Nature Cell Biology

Frequent co-authors with whom Scita has collaborated extensively include:

  • Andrea Palamidessi
  • Andrea Disanza
  • Claudio Tripodo
  • Emanuela Frittoli
  • Emanuele Martini

The scientist frequently publishes in several venues, such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Materials
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Advanced Science

Giorgio Scita has been recognized as a member of the European Molecular Biology Organization (EMBO), reflecting a formal acknowledgment within the molecular biology community.

Best Publications

  • The endocytic matrix

    Giorgio Scita;Pier Paolo Di Fiore;Pier Paolo Di Fiore

  • Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration.

    Andrea Palamidessi;Emanuela Frittoli;Massimiliano Garré;Mario Faretta

  • Vaccination of Metastatic Melanoma Patients With Autologous Tumor-Derived Heat Shock Protein gp96-Peptide Complexes: Clinical and Immunologic Findings

    Filiberto Belli;Alessandro Testori;Licia Rivoltini;Michele Maio

  • Abi1 is essential for the formation and activation of a WAVE2 signalling complex

    Metello Innocenti;Adriana Zucconi;Andrea Disanza;Emanuela Frittoli

  • Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation

    Anika Steffen;Klemens Rottner;Julia Ehinger;Metello Innocenti

  • Recycling of vitamin E in human low density lipoproteins.

    VE Kagan;EA Serbinova;T Forte;G Scita

  • Novel Roles of Formin mDia2 in Lamellipodia and Filopodia Formation in Motile Cells

    Changsong Yang;Lubov Czech;Silke Gerboth;Shin-ichiro Kojima

  • EPS8 and E3B1 transduce signals from Ras to Rac

    Giorgio Scita;Johan Nordstrom;Roberta Carbone;Pierluigi Tenca

  • Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.

    Sara Sigismund;Stefano Confalonieri;Andrea Ciliberto;Simona Polo

  • The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

    Letizia Lanzetti;Vladimir Rybin;Maria Grazia Malabarba;Savvas Christoforidis;Savvas Christoforidis

  • Regulation of actin dynamics by WASP and WAVE family proteins.

    Theresia E.B. Stradal;Klemens Rottner;Andrea Disanza;Stefano Confalonieri

  • Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases

    Letizia Lanzetti;Andrea Palamidessi;Liliana Areces;Giorgio Scita

  • Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

    Metello Innocenti;Emanuela Frittoli;Isabella Ponzanelli;John R. Falck

  • Protein complexes regulating Arp2/3-mediated actin assembly.

    Theresia E B Stradal;Giorgio Scita

  • Endocytic reawakening of motility in jammed epithelia

    Chiara Malinverno;Salvatore Corallino;Fabio Giavazzi;Martin Bergert

  • IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions

    Giorgio Scita;Stefano Confalonieri;Pekka Lappalainen;Shiro Suetsugu

  • Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.

    Andrea Disanza;Sara Mantoani;Maud Hertzog;Silke Gerboth

  • Signaling from Ras to Rac and beyond: not just a matter of GEFs.

    Giorgio Scita;Pierluigi Tenca;Emanuela Frittoli;Arianna Tocchetti

  • Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement.

    A. Disanza;A. Steffen;M. Hertzog;E. Frittoli

  • Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

    Metello Innocenti;Silke Gerboth;Klemens Rottner;Frank P. L. Lai

Frequent Co-Authors

Pier Paolo Di Fiore
Pier Paolo Di Fiore University of Milan
Stefano Confalonieri
Stefano Confalonieri European Institute of Oncology
Theresia E. B. Stradal
Theresia E. B. Stradal Helmholtz Centre for Infection Research
Klemens Rottner
Klemens Rottner Technische Universität Braunschweig
George Wolf
George Wolf University of California, Berkeley
Claudio Tripodo
Claudio Tripodo FIRC Institute of Molecular Oncology
Marie-France Carlier
Marie-France Carlier Centre national de la recherche scientifique, CNRS
Giuseppe Viale
Giuseppe Viale University of Milan
Michela Matteoli
Michela Matteoli Humanitas University
Philippe Chavrier
Philippe Chavrier Institute Curie

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