D-Index & Metrics Best Publications
Pier Paolo Di Fiore

Pier Paolo Di Fiore

Biology and Biochemistry
Italy
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 98 Citations 31,903 234 World Ranking 1099 National Ranking 12

Research.com Recognitions

Awards & Achievements

2023 - Research.com Biology and Biochemistry in Italy Leader Award

2022 - Research.com Biology and Biochemistry in Italy Leader Award

2010 - Member of Academia Europaea

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

Pier Paolo Di Fiore mainly focuses on Cell biology, Signal transduction, Endocytosis, Endocytic cycle and Ubiquitin. His Cell biology study which covers Actin remodeling that intersects with Arp2/3 complex. His research integrates issues of Receptor, Epidermal growth factor, Kinase and Cell in his study of Signal transduction.

His Endocytosis study combines topics from a wide range of disciplines, such as Internalization, Cell signaling and Actin. His work carried out in the field of Endocytic cycle brings together such families of science as Endosome, Signalling and Cell fate determination. His Ubiquitin research includes themes of Protein structure and Plasma protein binding.

His most cited work include:

  • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. (726 citations)
  • Clathrin-independent endocytosis of ubiquitinated cargos (724 citations)
  • Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation (718 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Cell biology, Endocytosis, Endocytic cycle, Cancer research and Signal transduction. His biological study focuses on Receptor tyrosine kinase. His work deals with themes such as Cell signaling and Signal transducing adaptor protein, which intersect with Endocytosis.

His Endocytic cycle research incorporates elements of Synaptic vesicle recycling, Endosome and Dynamin. His Cancer research research includes elements of Cancer, Cancer stem cell, Stem cell, NUMB and Immunology. His Signal transduction research incorporates themes from Receptor and Epidermal growth factor.

He most often published in these fields:

  • Cell biology (80.00%)
  • Endocytosis (29.51%)
  • Endocytic cycle (27.54%)

What were the highlights of his more recent work (between 2013-2021)?

  • Cancer research (26.56%)
  • Cell biology (80.00%)
  • Cancer (15.41%)

In recent papers he was focusing on the following fields of study:

Pier Paolo Di Fiore focuses on Cancer research, Cell biology, Cancer, Breast cancer and Endocytic cycle. His Cancer research research integrates issues from Carcinogenesis, Cancer stem cell, Stem cell, Immunology and Metastasis. His studies in Cell biology integrate themes in fields like Internalization, Epidermal growth factor receptor and Cell polarity.

His Cancer research is multidisciplinary, incorporating elements of Regulation of gene expression, Lung cancer, Downregulation and upregulation and Computational biology. He interconnects Scaffold protein, In silico, Gene and Oncology in the investigation of issues within Breast cancer. His Endocytic cycle study deals with the bigger picture of Endocytosis.

Between 2013 and 2021, his most popular works were:

  • miR-Test: A Blood Test for Lung Cancer Early Detection (139 citations)
  • Endocytosis, Signaling, and Beyond (112 citations)
  • The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death (110 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

His main research concerns Cell biology, Endocytic cycle, Cancer research, Endosome and Epidermal growth factor receptor. The concepts of his Cell biology study are interwoven with issues in Internalization, Bioinformatics and Clathrin. His research in Endocytic cycle intersects with topics in Cell adhesion and Cell polarity.

Pier Paolo Di Fiore has included themes like Immunology, Transactivation, Motility and Transforming growth factor, Transforming growth factor beta in his Cancer research study. He has researched Endosome in several fields, including Ubiquitin and GTPase. The various areas that Pier Paolo Di Fiore examines in his Signal transduction study include Mitosis and Cell membrane.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content.

Salvatore Pece;Daniela Tosoni;Stefano Confalonieri;Giovanni Mazzarol.
Cell (2010)

1027 Citations

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

Kaisa Haglund;Sara Sigismund;Simona Polo;Iwona Szymkiewicz.
Nature Cell Biology (2003)

1003 Citations

Clathrin-independent endocytosis of ubiquitinated cargos

Sara Sigismund;Tanja Woelk;Claudia Puri;Elena Maspero.
Proceedings of the National Academy of Sciences of the United States of America (2005)

980 Citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

Pier Paolo Di Fiore;Jacalyn H. Pierce;Timothy P. Fleming;Rachel Hazan.
Cell (1987)

839 Citations

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

Angelo Cicalese;Giuseppina Bonizzi;Cristina E. Pasi;Mario Faretta.
Cell (2009)

804 Citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

Simona Polo;Sara Sigismund;Mario Faretta;Monica Guidi.
Nature (2002)

792 Citations

Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.

Sara Sigismund;Elisabetta Argenzio;Daniela Tosoni;Elena Cavallaro.
Developmental Cell (2008)

742 Citations

Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis

Hong Chen;Silvia Fre;Vladimir I. Slepnev;Maria Rosaria Capua.
Nature (1998)

653 Citations

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis.

Salvatore Pece;Michela Serresi;Elisa Santolini;Maria Capra.
Journal of Cell Biology (2004)

583 Citations

The endocytic matrix

Giorgio Scita;Pier Paolo Di Fiore;Pier Paolo Di Fiore.
Nature (2010)

519 Citations

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