D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 64 Citations 12,381 143 World Ranking 4346 National Ranking 2167

Research.com Recognitions

Awards & Achievements

2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Amino acid

Robert L. Geahlen spends much of his time researching Biochemistry, Tyrosine kinase, Molecular biology, Kinase and Tyrosine phosphorylation. His work in the fields of Biochemistry, such as Phosphorylation, Protein tyrosine phosphatase, Enzyme inhibitor and Kinase activity, overlaps with other areas such as Tyrosine-kinase inhibitor. His work deals with themes such as Stereochemistry and Immunoprecipitation, which intersect with Tyrosine kinase.

His Kinase research includes elements of Protein biosynthesis, T cell, Piceatannol and Syk. His biological study spans a wide range of topics, including SH2 domain and LYN. Robert L. Geahlen combines subjects such as Proto-oncogene tyrosine-protein kinase Src, Mitogen-activated protein kinase kinase, Protein phosphorylation, Receptor tyrosine kinase and MAP2K7 with his study of Tyrosine phosphorylation.

His most cited work include:

  • PERINATAL LETHALITY AND BLOCKED B-CELL DEVELOPMENT IN MICE LACKING THE TYROSINE KINASE SYK (654 citations)
  • Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. (320 citations)
  • Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. (273 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Biochemistry, Syk, Cell biology, Phosphorylation and Kinase. His research on Biochemistry often connects related areas such as Molecular biology. His Syk research is multidisciplinary, relying on both Cancer research, B-cell receptor, LYN and breakpoint cluster region.

In his work, Cytosol is strongly intertwined with Cell, which is a subfield of Cell biology. His Tyrosine research extends to the thematically linked field of Phosphorylation. His study looks at the relationship between Kinase and fields such as Stereochemistry, as well as how they intersect with chemical problems.

He most often published in these fields:

  • Biochemistry (54.71%)
  • Syk (35.29%)
  • Cell biology (33.53%)

What were the highlights of his more recent work (between 2009-2019)?

  • Syk (35.29%)
  • Cell biology (33.53%)
  • Biochemistry (54.71%)

In recent papers he was focusing on the following fields of study:

Robert L. Geahlen focuses on Syk, Cell biology, Biochemistry, Phosphorylation and Kinase. His Syk research is multidisciplinary, incorporating perspectives in Tyrosine, Tyrosine phosphorylation and Cancer research. His Tyrosine phosphorylation research is multidisciplinary, incorporating elements of Molecular biology, Cell growth and Phosphopeptide.

The study incorporates disciplines such as Cell, Transcription factor, NFAT and Cytosol in addition to Cell biology. His Kinase course of study focuses on CREB and Mass spectrometry, Complementation and In vitro. Robert L. Geahlen has included themes like VAV1 and RNA interference in his Tyrosine kinase study.

Between 2009 and 2019, his most popular works were:

  • Getting Syk: spleen tyrosine kinase as a therapeutic target (126 citations)
  • In-depth Analyses of Kinase-dependent Tyrosine Phosphoproteomes Based on Metal Ion-functionalized Soluble Nanopolymers (125 citations)
  • Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates (91 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

Robert L. Geahlen mostly deals with Cell biology, Syk, Biochemistry, Cancer research and Epithelial–mesenchymal transition. His Cell biology study combines topics in areas such as Cell, Viscosity and Actin cytoskeleton. Syk is the subject of his research, which falls under Signal transduction.

His MAPK14, Cyclin-dependent kinase 2, Mitogen-activated protein kinase kinase, MAP2K7 and Proteomics investigations are all subjects of Biochemistry research. His studies in Epithelial–mesenchymal transition integrate themes in fields like Carcinogenesis, Fostamatinib, Transforming growth factor beta and ErbB. His work carried out in the field of Kinase brings together such families of science as HEK 293 cells, Innate immune system and Phosphorylation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

PERINATAL LETHALITY AND BLOCKED B-CELL DEVELOPMENT IN MICE LACKING THE TYROSINE KINASE SYK

M. Turner;P. J. Mee;P. S. Costello;O. Williams.
Nature (1995)

838 Citations

Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.

J M Oliver;D L Burg;B S Wilson;J L McLaughlin.
Journal of Biological Chemistry (1994)

397 Citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

J E Hutchcroft;M L Harrison;R L Geahlen.
Journal of Biological Chemistry (1992)

349 Citations

Kinase inhibitors from Polygonum cuspidatum

Gamini S. Jayatilake;Hiranthi Jayasuriya;Eung-Seok Lee;Nuphavan M. Koonchanok.
Journal of Natural Products (1993)

339 Citations

Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells.

Jill E. Hutchcroft;Robert L. Geahlen;Grace G. Deanin;Janet M. Oliver.
Proceedings of the National Academy of Sciences of the United States of America (1992)

277 Citations

Cloning and expression of a protein-tyrosine-phosphatase.

Kunliang Guan;Randy S. Haun;Stanley J. Watson;Robert L. Geahlen.
Proceedings of the National Academy of Sciences of the United States of America (1990)

269 Citations

Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum.

Hiranthi Jayasuriya;Nuphavan M. Koonchanok;Robert L. Geahlen;Jerry L. McLaughlin.
Journal of Natural Products (1992)

259 Citations

Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor.

Robert L. Geahlen;Jerry L. McLaughlin.
Biochemical and Biophysical Research Communications (1989)

250 Citations

DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase.

Daniel W. McVicar;Lynn S. Taylor;Pierre Gosselin;Jami Willette-Brown.
Journal of Biological Chemistry (1998)

236 Citations

Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues.

Mark Cushman;Dhanapalan Nagarathnam;Debra L. Burg;Robert L. Geahlen.
Journal of Medicinal Chemistry (1991)

231 Citations

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