2013 - Fellow of the American Association for the Advancement of Science (AAAS)
Robert L. Geahlen spends much of his time researching Biochemistry, Tyrosine kinase, Molecular biology, Kinase and Tyrosine phosphorylation. His work in the fields of Biochemistry, such as Phosphorylation, Protein tyrosine phosphatase, Enzyme inhibitor and Kinase activity, overlaps with other areas such as Tyrosine-kinase inhibitor. His work deals with themes such as Stereochemistry and Immunoprecipitation, which intersect with Tyrosine kinase.
His Kinase research includes elements of Protein biosynthesis, T cell, Piceatannol and Syk. His biological study spans a wide range of topics, including SH2 domain and LYN. Robert L. Geahlen combines subjects such as Proto-oncogene tyrosine-protein kinase Src, Mitogen-activated protein kinase kinase, Protein phosphorylation, Receptor tyrosine kinase and MAP2K7 with his study of Tyrosine phosphorylation.
His primary areas of investigation include Biochemistry, Syk, Cell biology, Phosphorylation and Kinase. His research on Biochemistry often connects related areas such as Molecular biology. His Syk research is multidisciplinary, relying on both Cancer research, B-cell receptor, LYN and breakpoint cluster region.
In his work, Cytosol is strongly intertwined with Cell, which is a subfield of Cell biology. His Tyrosine research extends to the thematically linked field of Phosphorylation. His study looks at the relationship between Kinase and fields such as Stereochemistry, as well as how they intersect with chemical problems.
Robert L. Geahlen focuses on Syk, Cell biology, Biochemistry, Phosphorylation and Kinase. His Syk research is multidisciplinary, incorporating perspectives in Tyrosine, Tyrosine phosphorylation and Cancer research. His Tyrosine phosphorylation research is multidisciplinary, incorporating elements of Molecular biology, Cell growth and Phosphopeptide.
The study incorporates disciplines such as Cell, Transcription factor, NFAT and Cytosol in addition to Cell biology. His Kinase course of study focuses on CREB and Mass spectrometry, Complementation and In vitro. Robert L. Geahlen has included themes like VAV1 and RNA interference in his Tyrosine kinase study.
Robert L. Geahlen mostly deals with Cell biology, Syk, Biochemistry, Cancer research and Epithelial–mesenchymal transition. His Cell biology study combines topics in areas such as Cell, Viscosity and Actin cytoskeleton. Syk is the subject of his research, which falls under Signal transduction.
His MAPK14, Cyclin-dependent kinase 2, Mitogen-activated protein kinase kinase, MAP2K7 and Proteomics investigations are all subjects of Biochemistry research. His studies in Epithelial–mesenchymal transition integrate themes in fields like Carcinogenesis, Fostamatinib, Transforming growth factor beta and ErbB. His work carried out in the field of Kinase brings together such families of science as HEK 293 cells, Innate immune system and Phosphorylation.
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PERINATAL LETHALITY AND BLOCKED B-CELL DEVELOPMENT IN MICE LACKING THE TYROSINE KINASE SYK
M. Turner;P. J. Mee;P. S. Costello;O. Williams.
Nature (1995)
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.
J M Oliver;D L Burg;B S Wilson;J L McLaughlin.
Journal of Biological Chemistry (1994)
Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.
J E Hutchcroft;M L Harrison;R L Geahlen.
Journal of Biological Chemistry (1992)
Kinase inhibitors from Polygonum cuspidatum
Gamini S. Jayatilake;Hiranthi Jayasuriya;Eung-Seok Lee;Nuphavan M. Koonchanok.
Journal of Natural Products (1993)
Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells.
Jill E. Hutchcroft;Robert L. Geahlen;Grace G. Deanin;Janet M. Oliver.
Proceedings of the National Academy of Sciences of the United States of America (1992)
Cloning and expression of a protein-tyrosine-phosphatase.
Kunliang Guan;Randy S. Haun;Stanley J. Watson;Robert L. Geahlen.
Proceedings of the National Academy of Sciences of the United States of America (1990)
Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum.
Hiranthi Jayasuriya;Nuphavan M. Koonchanok;Robert L. Geahlen;Jerry L. McLaughlin.
Journal of Natural Products (1992)
Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor.
Robert L. Geahlen;Jerry L. McLaughlin.
Biochemical and Biophysical Research Communications (1989)
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase.
Daniel W. McVicar;Lynn S. Taylor;Pierre Gosselin;Jami Willette-Brown.
Journal of Biological Chemistry (1998)
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues.
Mark Cushman;Dhanapalan Nagarathnam;Debra L. Burg;Robert L. Geahlen.
Journal of Medicinal Chemistry (1991)
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