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Joseph B. Bolen

Joseph B. Bolen

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
25744
World Ranking
3487
National Ranking
213

Overview

Joseph B. Bolen is affiliated with Takeda in Japan, contributing to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology.

Their work encompasses several subfields including Molecular Biology, Immunology, Radiology, Nuclear Medicine and Imaging, and Computational Theory and Mathematics. The scientist's research focuses on multiple key topics such as Immunotherapy and Immune Responses, vaccines and immunoinformatics approaches, Monoclonal and Polyclonal Antibodies Research, Galectins and Cancer Biology, Toxin Mechanisms and Immunotoxins, Bioinformatics and Genomic Networks, and Computational Drug Discovery Methods.

Joseph B. Bolen has been involved in publishing scientific articles in several venues, notably:

  • Frontiers in Cell and Developmental Biology
  • Regular and Young Investigator Award Abstracts
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genetics in Medicine Open

The recent scientific papers authored or co-authored by Joseph B. Bolen include:

  • "Progress Toward Identifying Exact Proxies for Predicting Response to Immunotherapies," 2020, Frontiers in Cell and Developmental Biology
  • "482 Phase1/2 study of an anti-galectin-9 antibody, LYT-200, in patients with metastatic solid tumors," 2021, Regular and Young Investigator Award Abstracts
  • "Scale-free structure of cancer networks and their vulnerability to hub-directed combination therapy," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "P453: PTEN and WDR19 variants in a neonate with brain and cutaneous anomalies," 2025, Genetics in Medicine Open

The scientist has collaborated with a range of co-authors including Aleksandra Filipović, George Miller, Zev Wainber, and Judy Wang.

Best Publications

  • An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

    Teresa A. Soucy;Peter G. Smith;Michael A. Milhollen;Allison J. Berger

  • The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

    André Veillette;Michael A. Bookman;Eva M. Horak;Joseph B. Bolen

  • Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

    André Veillette;Michael A. Bookman;Eva M. Horak;Lawrence E. Samelson

  • Syk tyrosine kinase required for mouse viability and B-cell development

    Alec M. Cheng;Bruce Rowley;William Pao;Adrian Hayday

  • Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases.

    E Eiseman;J B Bolen

  • Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

    James E. Brownell;Michael D. Sintchak;James M. Gavin;Hua Liao

  • Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

    Mark G. Manfredi;Jeffrey A. Ecsedy;Kristan A. Meetze;Suresh K. Balani

  • Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

    Anne L. Burkhardt;Mark Brunswick;Joseph B. Bolen;James J. Mond

  • Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

    Min-Mei Huang;Joseph B. Bolen;John W. Barnwell;Sanford J. Shattil

  • Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.

    Cheryl L. Miller;Anne L. Burkhardt;Jennifer H. Lee;Becky Stealey

  • Activation of pp60c-src protein kinase activity in human colon carcinoma.

    Joseph B. Bolen;Andre Veillette;Arnold M. Schwartz;Virginia Deseau

  • Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn.

    I Stefanová;M L Corcoran;E M Horak;L M Wahl

  • Nonreceptor tyrosine protein kinases.

    Bolen Jb

  • Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

    R. B. Rowley;A. L. Burkhardt;Hann-Guang Chao;G. R. Matsueda

  • Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation

    Joseph B. Bolen;Carol J. Thiele;Mark A. Israel;Wes Yonemoto

  • Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement

    S. J. Saouaf;Sandeep Mahajan;R. B. Rowley;S. A. Kut

  • Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

    FM Uckun;WE Evans;CJ Forsyth;KG Waddick

  • MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

    Michael A. Milhollen;Tary Traore;Jennifer Adams-Duffy;Michael P. Thomas

  • Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.

    N Rosen;J B Bolen;A M Schwartz;P Cohen

  • Characterization of Alisertib (MLN8237), An Investigational Small Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays

    Mark G. Manfredi;Jeffrey A. Ecsedy;Arijit Chakravarty;Lee Silverman

Frequent Co-Authors

André Veillette
André Veillette University of Montreal
Neal Rosen
Neal Rosen Memorial Sloan Kettering Cancer Center
Barbara M. Bröker
Barbara M. Bröker Greifswald University Hospital
Ivan D. Horak
Ivan D. Horak Freie Universität Berlin
Jeffrey A. Ledbetter
Jeffrey A. Ledbetter University of Washington
Tomohiro Kurosaki
Tomohiro Kurosaki Osaka University
Gary L. Schieven
Gary L. Schieven Genesis Biotechnology Group
Terrence R. Burke
Terrence R. Burke National Institutes of Health
Helmut Fickenscher
Helmut Fickenscher Kiel University
Joan S. Brugge
Joan S. Brugge Harvard University

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