Gary L. Schieven

Overview

Best Publications

• Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

  Louis J. Lombardo;Francis Y. Lee;Ping Chen;Derek Norris

  1295
  Citations

• Positive selection for loss of tetracycline resistance.

  B R Bochner;H C Huang;G L Schieven;B N Ames

  1054
  Citations

• 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.

  Jagabandhu Das;Ping Chen;Derek Norris;Ramesh Padmanabha

  563
  Citations

• Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

  Carl H. June;Mary C. Fletcher;Jeffrey A. Ledbetter;Gary L. Schieven

  510
  Citations

• The biology of p38 kinase: a central role in inflammation.

  Gary L. Schieven

  428
  Citations

• Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

  Gary L. Schieven;Jean M. Kirihara;Dorothea E. Myers;Jeffrey A. Ledbetter

  368
  Citations

• Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation.

  Andrew E. Schade;Gary L. Schieven;Robert Townsend;Anna M. Jankowska

  316
  Citations

• Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

  P A Kiener;B M Rankin;A L Burkhardt;G L Schieven

  274
  Citations

• CD28 ligation in T-cell activation: evidence for two signal transduction pathways.

  Jeffrey A. Ledbetter;John B. Imboden;Gary L. Schieven;Laura S. Grosmaire

  256
  Citations

• The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation.

  Peter J L Lane;Fiona M. McConnell;Gary L. Schieven;Edward A. Clark

  223
  Citations

• ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.

  Gary L. Schieven;Robert S. Mittler;Steven G. Nadler;Jean M. Kirihara

  218
  Citations

• The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release.

  Peter J L Lane;Jeffrey A. Ledbetter;Fiona M. Mcconnell;Kevin Draves

  215
  Citations

• p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals.

  Gary L. Schieven;Jean M. Kirihara;Debra L. Burg;Robert L. Geahlen

  212
  Citations

• Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fc gamma-IIA receptor.

  F. Yanaga;A. Poole;J. Asselin;R. Blake

  208
  Citations

• Cloning and expression of the tumor-associated antigen L6.

  John S. Marken;Gary L. Schieven;Ingegerd Hellstrom;Karl Erik Hellstrom

  206
  Citations

• Role of Oxidative Stress in the Action of Vanadium Phosphotyrosine Phosphatase Inhibitors REDOX INDEPENDENT ACTIVATION OF NF-κB

  Cecile M. Krejsa;Steven G. Nadler;James M. Esselstyn;Terrance J. Kavanagh

  204
  Citations

• Collagen stimulates tyrosine phosphorylation of phospholipase C‐γ2 but not phospholipase C‐γ1 in human platelets

  Robert A. Blake;Gary L. Schieven;Steve P. Watson

  200
  Citations

• Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors

  Fatih M. Uckun;Gary L. Schieven;Lisa M. Tuel-Ahlgren;Ilker Dibirdik

  192
  Citations

• Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation

  Jeffrey D. Bradshaw;Pin Lu;Gina Leytze;Julie Rodgers

  180
  Citations

• Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.

  Fatih M. Uckun;Gary L. Schieven;Ilker Dibirdik;Mridula Chandan-Langlie

  179
  Citations