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Immunology

D-Index
127
Citations
106198
World Ranking
257
National Ranking
166

Overview

Peter S. Linsley is affiliated with the Benaroya Research Institute in the United States. Their research primarily focuses on immunology and diabetes-related fields, with contributions spanning immunology and microbiology, biochemistry, genetics and molecular biology, as well as medicine.

The scientist has published extensively in several prominent journals, including:

  • The Journal of Immunology
  • JCI Insight
  • Diabetes Care
  • Diabetes
  • Nature Communications

Key research topics covered in their work include:

  • Diabetes and associated disorders
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Diabetes Management and Research
  • Pancreatic function and diabetes
  • Immunotherapy and Immune Responses
  • Single-cell and spatial transcriptomics

Frequent co-authors in their research collaborations are:

  • Carla J. Greenbaum
  • S. Alice Long
  • Karen Cerosaletti
  • Vivian H. Gersuk
  • Gerald T. Nepom

Selected recent papers highlight their research interests in immunology, diabetes, and cellular therapies:

  • "Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy," 2020, Nature Communications
  • "Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial," 2023, Diabetes Care
  • "Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects," 2020, JCI Insight
  • "Pancreatic islet-specific engineered T regs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models," 2022, Science Translational Medicine
  • "Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol," 2021, Hepatology Communications

Their publications demonstrate significant involvement in studies related to immune cell function, pancreatic islet biology, and immunotherapies addressing diabetes and related metabolic disorders.

Best Publications

  • Gene expression profiling predicts clinical outcome of breast cancer

    Laura J. van 't Veer;Hongyue Dai;Marc J. van de Vijver;Yudong D. He

  • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

    Lee P. Lim;Nelson C. Lau;Philip Garrett-Engele;Andrew Grimson

  • A microRNA component of the p53 tumour suppressor network

    Lin He;Xingyue He;Xingyue He;Lee P. Lim;Elisa de Stanchina;Elisa de Stanchina

  • MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

    Greg Finak;Andrew McDavid;Masanao Yajima;Jingyuan Deng

  • Expression profiling reveals off-target gene regulation by RNAi

    Aimee L Jackson;Steven R Bartz;Janell Schelter;Sumire V Kobayashi

  • CTLA-4 can function as a negative regulator of T cell activation

    Theresa L. Walunas;Deborah J. Lenschow;Christina Y. Bakker;Peter S. Linsley

  • CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

    Richard V. Parry;Jens M. Chemnitz;Kenneth A. Frauwirth;Anthony R. Lanfranco

  • CTLA-4 is a second receptor for the B cell activation antigen B7.

    Peter S. Linsley;William Brady;Mark Urnes;Laura S. Grosmaire

  • Genetics of gene expression surveyed in maize, mouse and man

    Eric E. Schadt;Stephanie A. Monks;Thomas A. Drake;Aldons J. Lusis

  • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.

    Christian P. Larsen;Eric T. Elwood;Diane Z. Alexander;Shannon C. Ritchie

  • The role of the CD28 receptor during T cell responses to antigen.

    Peter S. Linsley;Jeffrey A. Ledbetter

  • Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer.

    Timothy R. Hughes;Mao Mao;Allan R. Jones;Julja Burchard

  • Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

    Peter S. Linsley;William Brady;Laura Grosmaire;Alejandro Aruffo

  • Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

    DJ Lenschow;Y Zeng;Thistlethwaite;A Montag

  • A large-scale RNAi screen in human cells identifies new components of the p53 pathway

    Katrien Berns;E. Marielle Hijmans;Jasper Mullenders;Thijn R. Brummelkamp

  • Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

    Lieping Chen;Stephanie Ashe;William A. Brady;Ingegerd Hellström

  • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application.

    Aimee L. Jackson;Peter S. Linsley

  • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

    Peter S. Linsley;JoAnne L. Greene;William Brady;Jürgen Bajorath

  • Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.

    Aimee L. Jackson;Julja Burchard;Janell Schelter;B. Nelson Chau

  • MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

    Galina Gabriely;Thomas Wurdinger;Santosh Kesari;Christine C. Esau

  • CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms.

    Jens M. Chemnitz;James L. Riley;Kenneth A. Frauwirth;Inbal Braunstein

Frequent Co-Authors

Jeffrey A. Ledbetter
Jeffrey A. Ledbetter University of Washington
Jürgen Bajorath
Jürgen Bajorath University of Bonn
Peter D. Senter
Peter D. Senter Seattle Genetics (United States)
Alejandro Aruffo
Alejandro Aruffo Syngenta (United States)
Christian P. Larsen
Christian P. Larsen Emory University
Diane Hollenbaugh
Diane Hollenbaugh Bonum Therapeutics
Michele A. Cleary
Michele A. Cleary MSD (United States)
Lieping Chen
Lieping Chen Yale University
William C. Gause
William C. Gause Rutgers, The State University of New Jersey
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center

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