World's Best Scientists 2026 revealed!
Hideo Yagita

Hideo Yagita

Award Badge
Immunology
Japan
2026
Award Badge
Medicine
Japan
2026

D-Index & Metrics

Best Scientists

D-Index
165
Citations
100915
World Ranking
1044
National Ranking
17

Immunology

D-Index
166
Citations
103086
World Ranking
62
National Ranking
4

Medicine

D-Index
166
Citations
103617
World Ranking
608
National Ranking
8

Research.com Recognitions

  • 2026 - Research.com Immunology in Japan Leader Award
  • 2026 - Research.com Medicine in Japan Leader Award
  • 2025 - Research.com Immunology in Japan Leader Award
  • 2025 - Research.com Medicine in Japan Leader Award
  • 2023 - Research.com Immunology in Japan Leader Award
  • 2023 - Research.com Medicine in Japan Leader Award
  • 2022 - Research.com Immunology in Japan Leader Award
  • 2022 - Research.com Medicine in Japan Leader Award

Overview

Hideo Yagita is affiliated with Juntendo University in Japan, where their research primarily spans the fields of immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. Their subfields of study include immunology, molecular biology, oncology, physiology, and biomedical engineering.

Their research topics focus extensively on immune cell function and interaction, immunotherapy and immune responses, cancer immunotherapy and biomarkers, CAR-T cell therapy research, T-cell and B-cell immunology, fibroblast growth factor research, and the role of immune cells in cancer.

Hideo Yagita has contributed multiple papers in notable scientific journals. Some of the recent publications include:

  • The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1 (2021, Cancer Cell)
  • PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy (2021, Nature Communications)
  • Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer (2021, Nature Communications)
  • CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer (2021, Nature Communications)
  • Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice (2020, Human Molecular Genetics)

Their frequent co-authors include:

  • Hiroyasu Nakano
  • Takashi Nishina
  • Tetuo Mikami
  • Soh Yamazaki
  • Yuichi Tsuchiya

Hideo Yagita's research has been published in a variety of scientific venues, with multiple publications in:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal for ImmunoTherapy of Cancer
  • iScience
  • Journal of Allergy and Clinical Immunology

Best Publications

  • Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

    Yasutoshi Agata;Akemi Kawasaki;Hiroyuki Nishimura;Yasumasa Ishida

  • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

    Michael A. Curran;Welby Montalvo;Hideo Yagita;James P. Allison

  • Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.

    Tyler R. Simpson;Fubin Li;Welby Montalvo-Ortiz;Manuel A. Sepulveda

  • Expression of Programmed Death 1 Ligands by Murine T Cells and APC

    Tomohide Yamazaki;Hisaya Akiba;Hideyuki Iwai;Hironori Matsuda

  • Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer

    Takeo Nomi;Masayuki Sho;Takahiro Akahori;Kaoru Hamada

  • Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

    Yuichiro Ohigashi;Masayuki Sho;Yukishige Yamada;Yoshikazu Tsurui

  • VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors.

    Thibault Voron;Orianne Colussi;Elie Marcheteau;Simon Pernot

  • ATP drives lamina propria T H 17 cell differentiation

    Koji Atarashi;Junichi Nishimura;Tatsuichiro Shima;Yoshinori Umesaki

  • New aspects of natural-killer-cell surveillance and therapy of cancer

    Mark J. Smyth;Yoshihiro Hayakawa;Kazuyoshi Takeda;Hideo Yagita

  • The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.

    Mohammed Javeed I. Ansari;Alan D. Salama;Alan D. Salama;Tanuja Chitnis;Tanuja Chitnis;R. Neal Smith

  • Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

    Sergio A. Quezada;Tyler R. Simpson;Karl S. Peggs;Taha Merghoub

  • Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

    Madhav D. Sharma;Babak Baban;Phillip Chandler;De Yan Hou

  • Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells.

    Kazuyoshi Takeda;Yoshihiro Hayakawa;Mark J. Smyth;Nobuhiko Kayagaki

  • Activation of NK cell cytotoxicity.

    Mark J. Smyth;Erika Cretney;Janice M. Kelly;Jennifer A. Westwood

  • Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

    Shigeki Chiba;Muhammad Baghdadi;Hisaya Akiba;Hironori Yoshiyama

  • Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

    Jun-Li Luo;Shin Maeda;Li-Chung Hsu;Hideo Yagita

  • Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice

    Erika Cretney;Kazuyoshi Takeda;Hideo Yagita;Moira Glaccum

  • Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

    Nobuhiko Kayagaki;Noriko Yamaguchi;Masafumi Nakayama;Hiroshi Eto

  • Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis

    Alan D. Salama;Tanuja Chitnis;Tanuja Chitnis;Jaime Imitola;Jaime Imitola;Mohammed Javeed I. Ansari

  • Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

    Hiroyasu Nakano;Masahisa Shindo;Sachiko Sakon;Shigeyuki Nishinaka

Frequent Co-Authors

Ko Okumura
Ko Okumura Juntendo University
Hisaya Akiba
Hisaya Akiba Juntendo University
Miyuki Azuma
Miyuki Azuma Tokyo Medical and Dental University
Kazuyoshi Takeda
Kazuyoshi Takeda Juntendo University
Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute
Mohamed H. Sayegh
Mohamed H. Sayegh American University of Beirut
Hiroyasu Nakano
Hiroyasu Nakano Toho University
Nader Najafian
Nader Najafian Brigham and Women's Hospital
Tetsuji Kobata
Tetsuji Kobata Tokyo Medical and Dental University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For those interested in Immunology, exploring related healthcare degrees can open diverse career paths. Nursing professionals often seek specialized programs, such as an accelerated FNP program, which fast-tracks family nurse practitioner training to meet growing healthcare demands.

Transitioning between nursing specialties is also common. If you're an FNP looking to expand your skills, considering a FNP to acute care NP bridge program can provide the necessary education to shift into acute care settings.

For those new to nursing, 12-month accelerated nursing programs online for non nurses offer a streamlined route into the profession, enabling quicker entry into clinical roles supporting immunology research and patient care.

Career outlook also ties closely to salary expectations. Understanding how much do DNPs make in different states can inform decisions about where to specialize and practice, aligning educational choices with financial goals.

Best Scientists Citing Hideo Yagita

Trending Scientists