His main research concerns Perforin, Cell biology, Granzyme, Cytotoxic T cell and Granzyme B. His research integrates issues of Tumor necrosis factor alpha and Cell membrane in his study of Perforin. His work in Cell biology addresses subjects such as Immunosurveillance, which are connected to disciplines such as Proinflammatory cytokine.
His Granzyme research includes themes of Apoptosis, Programmed cell death, Fas receptor, Exocytosis and Pore forming protein. His work carried out in the field of Cytotoxic T cell brings together such families of science as Immunological synapse, Degranulation and Immunology, Effector. His research in Granzyme B intersects with topics in Proteases, Natural killer cell, Caspase, Molecular biology and Cell killing.
His primary areas of investigation include Cytotoxic T cell, Perforin, Granzyme, Cell biology and Immunology. His study in Cytotoxic T cell is interdisciplinary in nature, drawing from both Molecular biology, Cancer research, Immune system and Antigen. Joseph A. Trapani has included themes like Natural killer cell, Lymphocyte and Effector in his Perforin study.
His biological study spans a wide range of topics, including Proteases, Caspase and Granzyme B, Granzyme A. His studies deal with areas such as Apoptosis, Programmed cell death, Immunological synapse, Cell membrane and Degranulation as well as Cell biology. In most of his Immunology studies, his work intersects topics such as Cytotoxicity.
Joseph A. Trapani mainly focuses on Cancer research, Cytotoxic T cell, Cell biology, Perforin and Immune system. He combines subjects such as Cancer, Immunotherapy, T cell, Antigen and Regulation of gene expression with his study of Cancer research. His Cytotoxic T cell research is multidisciplinary, incorporating perspectives in Viral hepatitis, Exocytosis and Cell Degranulation.
His Cell biology research integrates issues from Perforin Deficiency, CD8, CRISPR and Lymphocyte. A large part of his Perforin studies is devoted to Granzyme. His research investigates the connection between Granzyme and topics such as Cell culture that intersect with issues in Molecular biology, In vivo and Stem cell.
Joseph A. Trapani mostly deals with Cancer research, Cytotoxic T cell, Immune system, Cell biology and Immunotherapy. His Cancer research research incorporates elements of Cancer cell, Cancer, Regulation of gene expression and Signal transducing adaptor protein. Joseph A. Trapani studies Cytotoxic T cell, focusing on Perforin in particular.
His Immune system research incorporates themes from Myeloid and Blockade. His Cell biology research focuses on Immunological synapse and how it relates to Natural killer T cell, Plasma membrane organization, Granzyme and Lymphocyte function-associated antigen 1. In his study, Antigen and Genome editing is strongly linked to T cell, which falls under the umbrella field of Immunotherapy.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Functional significance of the perforin/granzyme cell death pathway
Joseph A. Trapani;Mark J. Smyth.
Nature Reviews Immunology (2002)
Differential tumor surveillance by natural killer (NK) and NKT cells
Mark J. Smyth;Kevin Y. T. Thia;Shayna E.A. Street;Erika Cretney.
Journal of Experimental Medicine (2000)
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Teresa Fernandes-Alnemri;Robert C. Armstrong;Joseph Krebs;Srinivasa M. Srinivasula.
Proceedings of the National Academy of Sciences of the United States of America (1996)
A fresh look at tumor immunosurveillance and immunotherapy
Mark J. Smyth;Dale I. Godfrey;Joseph A. Trapani.
Nature Immunology (2001)
Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells
Thomas Luft;Ken C Pang;Elisabeth Thomas;Paul J Hertzog.
Journal of Immunology (1998)
Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma
Mark J. Smyth;Kevin Y.T. Thia;Shayna E.A. Street;Duncan MacGregor.
Journal of Experimental Medicine (2000)
Perforin-mediated target-cell death and immune homeostasis
Ilia Voskoboinik;Ilia Voskoboinik;Mark J. Smyth;Mark J. Smyth;Joseph A. Trapani;Joseph A. Trapani.
Nature Reviews Immunology (2006)
Perforin and granzymes: function, dysfunction and human pathology
Ilia Voskoboinik;Ilia Voskoboinik;James C. Whisstock;James C. Whisstock;Joseph A. Trapani;Joseph A. Trapani.
Nature Reviews Immunology (2015)
Granzymes: exogenous porteinases that induce target cell apoptosis
Mark.J. Smyth;Joseph A. Trapani.
Immunology Today (1995)
Suppression of lymphoma and epithelial malignancies effected by interferon gamma
Shayna E.A. Street;Joseph A. Trapani;Duncan MacGregor;Mark J. Smyth.
Journal of Experimental Medicine (2002)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: