What is he best known for?
The fields of study he is best known for:
- Gene
- Immune system
- Enzyme
His main research concerns Perforin, Cell biology, Granzyme, Cytotoxic T cell and Granzyme B.
His research integrates issues of Tumor necrosis factor alpha and Cell membrane in his study of Perforin.
His work in Cell biology addresses subjects such as Immunosurveillance, which are connected to disciplines such as Proinflammatory cytokine.
His Granzyme research includes themes of Apoptosis, Programmed cell death, Fas receptor, Exocytosis and Pore forming protein.
His work carried out in the field of Cytotoxic T cell brings together such families of science as Immunological synapse, Degranulation and Immunology, Effector.
His research in Granzyme B intersects with topics in Proteases, Natural killer cell, Caspase, Molecular biology and Cell killing.
His most cited work include:
- Functional significance of the perforin/granzyme cell death pathway (914 citations)
- Differential tumor surveillance by natural killer (NK) and NKT cells (713 citations)
- In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (693 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Cytotoxic T cell, Perforin, Granzyme, Cell biology and Immunology.
His study in Cytotoxic T cell is interdisciplinary in nature, drawing from both Molecular biology, Cancer research, Immune system and Antigen.
Joseph A. Trapani has included themes like Natural killer cell, Lymphocyte and Effector in his Perforin study.
His biological study spans a wide range of topics, including Proteases, Caspase and Granzyme B, Granzyme A.
His studies deal with areas such as Apoptosis, Programmed cell death, Immunological synapse, Cell membrane and Degranulation as well as Cell biology.
In most of his Immunology studies, his work intersects topics such as Cytotoxicity.
He most often published in these fields:
- Cytotoxic T cell (62.75%)
- Perforin (58.31%)
- Granzyme (49.67%)
What were the highlights of his more recent work (between 2017-2021)?
- Cancer research (25.72%)
- Cytotoxic T cell (62.75%)
- Cell biology (51.00%)
In recent papers he was focusing on the following fields of study:
Joseph A. Trapani mainly focuses on Cancer research, Cytotoxic T cell, Cell biology, Perforin and Immune system.
He combines subjects such as Cancer, Immunotherapy, T cell, Antigen and Regulation of gene expression with his study of Cancer research.
His Cytotoxic T cell research is multidisciplinary, incorporating perspectives in Viral hepatitis, Exocytosis and Cell Degranulation.
His Cell biology research integrates issues from Perforin Deficiency, CD8, CRISPR and Lymphocyte.
A large part of his Perforin studies is devoted to Granzyme.
His research investigates the connection between Granzyme and topics such as Cell culture that intersect with issues in Molecular biology, In vivo and Stem cell.
Between 2017 and 2021, his most popular works were:
- Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity. (97 citations)
- Tumor immune evasion arises through loss of TNF sensitivity (87 citations)
- Tumor immune evasion arises through loss of TNF sensitivity (87 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Immune system
- Enzyme
Joseph A. Trapani mostly deals with Cancer research, Cytotoxic T cell, Immune system, Cell biology and Immunotherapy.
His Cancer research research incorporates elements of Cancer cell, Cancer, Regulation of gene expression and Signal transducing adaptor protein.
Joseph A. Trapani studies Cytotoxic T cell, focusing on Perforin in particular.
His Immune system research incorporates themes from Myeloid and Blockade.
His Cell biology research focuses on Immunological synapse and how it relates to Natural killer T cell, Plasma membrane organization, Granzyme and Lymphocyte function-associated antigen 1.
In his study, Antigen and Genome editing is strongly linked to T cell, which falls under the umbrella field of Immunotherapy.
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