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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Immunology

D-Index
104
Citations
39430
World Ranking
616
National Ranking
19

Medicine

D-Index
104
Citations
39535
World Ranking
7056
National Ranking
204

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Joseph A. Trapani is affiliated with the Peter MacCallum Cancer Centre in Australia. Their research spans several interconnected fields including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. This multi-disciplinary focus supports investigations primarily in Immunology, Molecular Biology, Oncology, Hematology, and Public Health, Environmental and Occupational Health.

The scientist's research topics reflect a concentration on immune system behavior and cancer therapies. Key topics include Immune Cell Function and Interaction, CAR-T cell therapy research, Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, Autoimmune and Inflammatory Disorders Research, CRISPR and Genetic Engineering, and T-cell and B-cell Immunology.

Joseph A. Trapani has contributed to numerous publications, with frequent appearances in venues such as bioRxiv (Cold Spring Harbor Laboratory), Science Advances, HLA, Cancer Research, and Nature Communications. The breadth of their publication record indicates active engagement in high-impact and emerging scientific forums.

Selected recent papers exemplify their research focus:

  • Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion, 2020, Cancer Research
  • Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer, 2021, Science Advances
  • Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells, 2021, Nature
  • Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity, 2020, Nature Immunology
  • Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma, 2021, Nature Immunology

Coauthorship analysis reveals regular collaboration with other researchers in related fields. Frequent coauthors include:

  • Paul J. Neeson
  • Ilia Voskoboinik
  • Paul G. Ekert
  • Phillip K. Darcy
  • Michelle Haber

The intersection of Joseph A. Trapani's work with cancer immunotherapy and immune system modulation is demonstrated through their investigation of cellular therapies, immune checkpoints, and immune cell function. These efforts contribute to advancing understanding in tumor immunity, antiviral immune mechanisms, and therapeutic immune modulation.

Best Publications

  • Functional significance of the perforin/granzyme cell death pathway

    Joseph A. Trapani;Mark J. Smyth

  • Perforin and granzymes: function, dysfunction and human pathology

    Ilia Voskoboinik;Ilia Voskoboinik;James C. Whisstock;James C. Whisstock;Joseph A. Trapani;Joseph A. Trapani

  • Differential tumor surveillance by natural killer (NK) and NKT cells

    Mark J. Smyth;Kevin Y. T. Thia;Shayna E.A. Street;Erika Cretney

  • A fresh look at tumor immunosurveillance and immunotherapy

    Mark J. Smyth;Dale I. Godfrey;Joseph A. Trapani

  • In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

    Teresa Fernandes-Alnemri;Robert C. Armstrong;Joseph Krebs;Srinivasa M. Srinivasula

  • CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

    Marian L Burr;Marian L Burr;Marian L Burr;Christina E Sparbier;Yih-Chih Chan;James C Williamson

  • Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells

    Thomas Luft;Ken C Pang;Elisabeth Thomas;Paul J Hertzog

  • Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

    Mark J. Smyth;Kevin Y.T. Thia;Shayna E.A. Street;Duncan MacGregor

  • Perforin-mediated target-cell death and immune homeostasis

    Ilia Voskoboinik;Ilia Voskoboinik;Mark J. Smyth;Mark J. Smyth;Joseph A. Trapani;Joseph A. Trapani

  • Granzymes: exogenous porteinases that induce target cell apoptosis

    Mark.J. Smyth;Joseph A. Trapani

  • Suppression of lymphoma and epithelial malignancies effected by interferon gamma

    Shayna E.A. Street;Joseph A. Trapani;Duncan MacGregor;Mark J. Smyth

  • Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia.

    David S. Ritchie;Paul J. Neeson;Paul J. Neeson;Amit Khot;Stefan Peinert

  • Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

    Vivien R. Sutton;Joanne E. Davis;Michael Cancilla;Ricky W. Johnstone

  • The structural basis for membrane binding and pore formation by lymphocyte perforin

    Ruby H P Law;Natalya Lukoyanova;Ilia Voskoboinik;Ilia Voskoboinik;Tom T Caradoc-Davies

  • The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32

    Srinivasa M. Srinivasula;Teresa Fernandes-Alnemri;James Zangrilli;Noreen Robertson

  • Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion.

    Florida Voli;Emanuele Valli;Luigi Lerra;Kathleen Kimpton

  • Tumor immune evasion arises through loss of TNF sensitivity

    Conor J. Kearney;Conor J. Kearney;Stephin J. Vervoort;Stephin J. Vervoort;Simon J. Hogg;Simon J. Hogg;Kelly M. Ramsbottom

  • Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes

    Karin A Sedelies;Thomas J Sayers;Kirsten M Edwards;Weisan Chen

  • Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

    Sunil S Metkar;Baikun Wang;Miguel Aguilar-Santelises;Srikumar M Raja

  • A Cytosolic Granzyme B Inhibitor Related to the Viral Apoptotic Regulator Cytokine Response Modifier A Is Present in Cytotoxic Lymphocytes

    Jiuru Sun;Catherina H. Bird;Vivien Sutton;Lisa McDonald

  • Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

    Katherine L DeYoung;Michael E Ray;Michael E Ray;Yan A Su;Sarah L Anzick

  • Granzyme B: pro-apoptotic, antiviral and antitumor functions.

    Joseph A Trapani;Vivien R Sutton

Frequent Co-Authors

Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute
Ilia Voskoboinik
Ilia Voskoboinik Peter MacCallum Cancer Centre
Michael H. Kershaw
Michael H. Kershaw Peter MacCallum Cancer Centre
Phillip K. Darcy
Phillip K. Darcy Peter MacCallum Cancer Centre
Ricky W. Johnstone
Ricky W. Johnstone Peter MacCallum Cancer Centre
Phillip I. Bird
Phillip I. Bird Monash University
James C. Whisstock
James C. Whisstock Monash University
Nigel J. Waterhouse
Nigel J. Waterhouse QIMR Berghofer Medical Research Institute
David Ritchie
David Ritchie Peter MacCallum Cancer Centre
Paul A. Beavis
Paul A. Beavis Peter MacCallum Cancer Centre

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