H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 99 Citations 37,495 376 World Ranking 715 National Ranking 16

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Enzyme

His main research concerns Perforin, Cell biology, Granzyme, Cytotoxic T cell and Granzyme B. His research integrates issues of Tumor necrosis factor alpha and Cell membrane in his study of Perforin. His work in Cell biology addresses subjects such as Immunosurveillance, which are connected to disciplines such as Proinflammatory cytokine.

His Granzyme research includes themes of Apoptosis, Programmed cell death, Fas receptor, Exocytosis and Pore forming protein. His work carried out in the field of Cytotoxic T cell brings together such families of science as Immunological synapse, Degranulation and Immunology, Effector. His research in Granzyme B intersects with topics in Proteases, Natural killer cell, Caspase, Molecular biology and Cell killing.

His most cited work include:

  • Functional significance of the perforin/granzyme cell death pathway (914 citations)
  • Differential tumor surveillance by natural killer (NK) and NKT cells (713 citations)
  • In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. (693 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Cytotoxic T cell, Perforin, Granzyme, Cell biology and Immunology. His study in Cytotoxic T cell is interdisciplinary in nature, drawing from both Molecular biology, Cancer research, Immune system and Antigen. Joseph A. Trapani has included themes like Natural killer cell, Lymphocyte and Effector in his Perforin study.

His biological study spans a wide range of topics, including Proteases, Caspase and Granzyme B, Granzyme A. His studies deal with areas such as Apoptosis, Programmed cell death, Immunological synapse, Cell membrane and Degranulation as well as Cell biology. In most of his Immunology studies, his work intersects topics such as Cytotoxicity.

He most often published in these fields:

  • Cytotoxic T cell (62.75%)
  • Perforin (58.31%)
  • Granzyme (49.67%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cancer research (25.72%)
  • Cytotoxic T cell (62.75%)
  • Cell biology (51.00%)

In recent papers he was focusing on the following fields of study:

Joseph A. Trapani mainly focuses on Cancer research, Cytotoxic T cell, Cell biology, Perforin and Immune system. He combines subjects such as Cancer, Immunotherapy, T cell, Antigen and Regulation of gene expression with his study of Cancer research. His Cytotoxic T cell research is multidisciplinary, incorporating perspectives in Viral hepatitis, Exocytosis and Cell Degranulation.

His Cell biology research integrates issues from Perforin Deficiency, CD8, CRISPR and Lymphocyte. A large part of his Perforin studies is devoted to Granzyme. His research investigates the connection between Granzyme and topics such as Cell culture that intersect with issues in Molecular biology, In vivo and Stem cell.

Between 2017 and 2021, his most popular works were:

  • Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity. (97 citations)
  • Tumor immune evasion arises through loss of TNF sensitivity (87 citations)
  • Tumor immune evasion arises through loss of TNF sensitivity (87 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Enzyme

Joseph A. Trapani mostly deals with Cancer research, Cytotoxic T cell, Immune system, Cell biology and Immunotherapy. His Cancer research research incorporates elements of Cancer cell, Cancer, Regulation of gene expression and Signal transducing adaptor protein. Joseph A. Trapani studies Cytotoxic T cell, focusing on Perforin in particular.

His Immune system research incorporates themes from Myeloid and Blockade. His Cell biology research focuses on Immunological synapse and how it relates to Natural killer T cell, Plasma membrane organization, Granzyme and Lymphocyte function-associated antigen 1. In his study, Antigen and Genome editing is strongly linked to T cell, which falls under the umbrella field of Immunotherapy.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Functional significance of the perforin/granzyme cell death pathway

Joseph A. Trapani;Mark J. Smyth.
Nature Reviews Immunology (2002)

1368 Citations

Differential tumor surveillance by natural killer (NK) and NKT cells

Mark J. Smyth;Kevin Y. T. Thia;Shayna E.A. Street;Erika Cretney.
Journal of Experimental Medicine (2000)

975 Citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

Teresa Fernandes-Alnemri;Robert C. Armstrong;Joseph Krebs;Srinivasa M. Srinivasula.
Proceedings of the National Academy of Sciences of the United States of America (1996)

971 Citations

A fresh look at tumor immunosurveillance and immunotherapy

Mark J. Smyth;Dale I. Godfrey;Joseph A. Trapani.
Nature Immunology (2001)

948 Citations

Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells

Thomas Luft;Ken C Pang;Elisabeth Thomas;Paul J Hertzog.
Journal of Immunology (1998)

750 Citations

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

Mark J. Smyth;Kevin Y.T. Thia;Shayna E.A. Street;Duncan MacGregor.
Journal of Experimental Medicine (2000)

694 Citations

Perforin-mediated target-cell death and immune homeostasis

Ilia Voskoboinik;Ilia Voskoboinik;Mark J. Smyth;Mark J. Smyth;Joseph A. Trapani;Joseph A. Trapani.
Nature Reviews Immunology (2006)

583 Citations

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik;Ilia Voskoboinik;James C. Whisstock;James C. Whisstock;Joseph A. Trapani;Joseph A. Trapani.
Nature Reviews Immunology (2015)

577 Citations

Granzymes: exogenous porteinases that induce target cell apoptosis

Mark.J. Smyth;Joseph A. Trapani.
Immunology Today (1995)

490 Citations

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

Shayna E.A. Street;Joseph A. Trapani;Duncan MacGregor;Mark J. Smyth.
Journal of Experimental Medicine (2002)

459 Citations

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