Christopher J. Froelich

Overview

Best Publications

• An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin

  Steffen Stenger;Dennis A. Hanson;Rachel Teitelbaum;Puneet Dewan

  1443
  Citations

• Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

  Henning R. Stennicke;Juliane M. Jürgensmeier;Hwain Shin;Quinn Deveraux

  1023
  Citations

• Enhancement of natural cytotoxicity by beta-endorphin.

  P M Mathews;C J Froelich;W L Sibbitt;A D Bankhurst

  638
  Citations

• The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

  Kim A Orth;Arul M. Chinnaiyan;Manish Garg;Christopher J. Froelich

  604
  Citations

• New Paradigm for Lymphocyte Granule-mediated Cytotoxicity: TARGET CELLS BIND AND INTERNALIZE GRANZYME B, BUT AN ENDOSOMOLYTIC AGENT IS NECESSARY FOR CYTOSOLIC DELIVERY AND SUBSEQUENT APOPTOSIS *

  Christopher J. Froelich;Kim A Orth;Jane Turbov;Prem Seth

  541
  Citations

• ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

  Hangjun Duan;Kim A Orth;Arul M. Chinnaiyan;Guy G. Poirier

  412
  Citations

• Reconstitution of Caspase 3 Sensitizes MCF-7 Breast Cancer Cells to Doxorubicin- and Etoposide-induced Apoptosis

  Xiao He Yang;Todd L. Sladek;Xuesong Liu;Bryn R. Butler

  402
  Citations

• Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

  Sunil S Metkar;Baikun Wang;Miguel Aguilar-Santelises;Srikumar M Raja

  372
  Citations

• Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

  Sunil S. Metkar;Cheikh Menaa;Julian Pardo;Julian Pardo;Baikun Wang

  357
  Citations

• Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin

  Marguerite S. Buzza;Laura Zamurs;Jiuru Sun;Catherina H. Bird

  324
  Citations

• Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.

  Michael J. Pinkoski;Marita Hobman;Jeffrey A. Heibein;Kevin Tomaselli

  305
  Citations

• Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

  Kylie A. Browne;Elizabeth Blink;Vivien R. Sutton;Christopher J. Froelich

  262
  Citations

• Granule-mediated killing: Pathways for granzyme B-initiated apoptosis

  Robert V. Talanian;Xiao He Yang;Jane Turbov;Prem Seth

  251
  Citations

• Granzyme B Mimics Apical Caspases DESCRIPTION OF A UNIFIED PATHWAY FOR TRANS-ACTIVATION OF EXECUTIONER CASPASE-3 AND -7

  Xiaohe Yang;Henning R. Stennicke;Baikun Wang;Douglas R. Green

  244
  Citations

• Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo.

  E. H. A. Spaeny-Dekking;W. L. Hanna;A. M. Wolbink;P. C. Wever

  235
  Citations

• Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice.

  Thomas P. Johnston;Monika A. Punjabi;Christopher J. Froelich

  224
  Citations

• A Distinct Pathway of Cell-Mediated Apoptosis Initiated by Granulysin

  Allan A. Kaspar;Satoshi Okada;Jayant Kumar;Francis R. Poulain

  208
  Citations

• The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA).

  P P Tak;L Spaeny-Dekking;M C Kraan;F C Breedveld

  200
  Citations

• Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

  Christopher J. Froelich;Vishva M. Dixit;Xiaohe Yang

  198
  Citations

• Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

  Sunil S. Metkar;Baikun Wang;Michelle L. Ebbs;Jin H. Kim

  198
  Citations