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Christopher J. Froelich

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
14684
World Ranking
9171
National Ranking
4067

Christopher J. Froelich publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Christopher J. Froelich sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 138 publications — 21st percentile

21% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Christopher J. Froelich D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Christopher J. Froelich sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 65 D-Index — 55th percentile

55% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Christopher J. Froelich is affiliated with NorthShore University HealthSystem in the United States. Their research primarily focuses on fields related to Biochemistry, Genetics, and Molecular Biology, with significant contributions in Medicine. Within these broader fields, they have specialized in subfields including Genetics, Molecular Biology, Physiology, and Cardiology and Cardiovascular Medicine.

Their recent publications demonstrate a focus on virus-based gene therapy and related methodologies. Key papers include:

  • Evaluating rAAV Strength and Empty:Full Purity Using Orthogonal Methods, 2025, published in Cytotherapy
  • Breaking the Bottleneck in Lentiviral Production: Achieving Ultra-Low Infectivity-to-Particle Ratios and Cost Efficiency for Transformative Gene Therapies, 2025, published in Cytotherapy
  • Recombinant Adeno-Associated Virus (rAAV) Manufacturing Platforms: Process and Quality Considerations, 2025, published in Cytotherapy

Their work encompasses several main topics, including:

  • Virus-based gene therapy research
  • RNA Interference and Gene Delivery
  • Biomedical Ethics and Regulation
  • Viral Infectious Diseases and Gene Expression in Insects
  • Viral Infections and Immunology Research

Froelich has frequently published in the journal Cytotherapy, with three publications noted in this venue. Collaborations are a notable aspect of their research, with frequent coauthors including Pouria Motevalian, P. Motevalian, U. Lakshmipathy, A P Correia, and Mina Park.

Best Publications

  • An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin

    Steffen Stenger;Dennis A. Hanson;Rachel Teitelbaum;Puneet Dewan

  • Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

    Henning R. Stennicke;Juliane M. Jürgensmeier;Hwain Shin;Quinn Deveraux

  • Enhancement of natural cytotoxicity by beta-endorphin.

    P M Mathews;C J Froelich;W L Sibbitt;A D Bankhurst

  • The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

    Kim A Orth;Arul M. Chinnaiyan;Manish Garg;Christopher J. Froelich

  • New Paradigm for Lymphocyte Granule-mediated Cytotoxicity: TARGET CELLS BIND AND INTERNALIZE GRANZYME B, BUT AN ENDOSOMOLYTIC AGENT IS NECESSARY FOR CYTOSOLIC DELIVERY AND SUBSEQUENT APOPTOSIS *

    Christopher J. Froelich;Kim A Orth;Jane Turbov;Prem Seth

  • ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

    Hangjun Duan;Kim A Orth;Arul M. Chinnaiyan;Guy G. Poirier

  • Reconstitution of Caspase 3 Sensitizes MCF-7 Breast Cancer Cells to Doxorubicin- and Etoposide-induced Apoptosis

    Xiao He Yang;Todd L. Sladek;Xuesong Liu;Bryn R. Butler

  • Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

    Sunil S Metkar;Baikun Wang;Miguel Aguilar-Santelises;Srikumar M Raja

  • Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

    Sunil S. Metkar;Cheikh Menaa;Julian Pardo;Julian Pardo;Baikun Wang

  • Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin

    Marguerite S. Buzza;Laura Zamurs;Jiuru Sun;Catherina H. Bird

  • Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.

    Michael J. Pinkoski;Marita Hobman;Jeffrey A. Heibein;Kevin Tomaselli

  • Cytosolic delivery of granzyme B by bacterial toxins: Evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

    Kylie A. Browne;Elizabeth Blink;Vivien R. Sutton;Christopher J. Froelich

  • Granule-mediated killing: Pathways for granzyme B-initiated apoptosis

    Robert V. Talanian;Xiao He Yang;Jane Turbov;Prem Seth

  • Granzyme B Mimics Apical Caspases DESCRIPTION OF A UNIFIED PATHWAY FOR TRANS-ACTIVATION OF EXECUTIONER CASPASE-3 AND -7

    Xiaohe Yang;Henning R. Stennicke;Baikun Wang;Douglas R. Green

  • Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo.

    E. H. A. Spaeny-Dekking;W. L. Hanna;A. M. Wolbink;P. C. Wever

  • Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice.

    Thomas P. Johnston;Monika A. Punjabi;Christopher J. Froelich

  • A Distinct Pathway of Cell-Mediated Apoptosis Initiated by Granulysin

    Allan A. Kaspar;Satoshi Okada;Jayant Kumar;Francis R. Poulain

  • The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA).

    P P Tak;L Spaeny-Dekking;M C Kraan;F C Breedveld

  • Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

    Christopher J. Froelich;Vishva M. Dixit;Xiaohe Yang

  • Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

    Sunil S. Metkar;Baikun Wang;Michelle L. Ebbs;Jin H. Kim

Frequent Co-Authors

Markus M. Simon
Markus M. Simon Max Planck Society
Gregor Anderluh
Gregor Anderluh University of Ljubljana
Joseph A. Trapani
Joseph A. Trapani Peter MacCallum Cancer Centre
Prem Seth
Prem Seth University of Chicago
Mauro Dalla Serra
Mauro Dalla Serra Consiglio Nazionale delle Ricerche - CNR
Kim Orth
Kim Orth The University of Texas Southwestern Medical Center
Robert J. C. Gilbert
Robert J. C. Gilbert University of Oxford
Vishva M. Dixit
Vishva M. Dixit Genentech
David A. Jans
David A. Jans Monash University
Reinhard Wallich
Reinhard Wallich Heidelberg University

External Links

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Best Scientists Citing Christopher J. Froelich

Joseph A. Trapani

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Publications: 114

Phillip I. Bird

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Publications: 62

David J. Granville

David J. Granville

University of British Columbia

Publications: 58

Guy S. Salvesen

Guy S. Salvesen

Sanford Burnham Prebys Medical Discovery Institute

Publications: 57

Alan M. Krensky

Alan M. Krensky

Northwestern University

Publications: 48

Judy Lieberman

Judy Lieberman

Boston Children's Hospital

Publications: 47

Stefan H. E. Kaufmann

Stefan H. E. Kaufmann

Max Planck Institute for Infection Biology

Publications: 40

Mark J. Smyth

Mark J. Smyth

QIMR Berghofer Medical Research Institute

Publications: 37

Ilia Voskoboinik

Ilia Voskoboinik

Peter MacCallum Cancer Centre

Publications: 37

Robert L. Modlin

Robert L. Modlin

University of California, Los Angeles

Publications: 35

R. Chris Bleackley

R. Chris Bleackley

University of Alberta

Publications: 35

Gregor Anderluh

Gregor Anderluh

University of Ljubljana

Publications: 32

John C. Reed

John C. Reed

Johnson & Johnson (United States)

Publications: 30

Steffen Stenger

Steffen Stenger

University of Ulm

Publications: 29

Vishva M. Dixit

Vishva M. Dixit

Genentech

Publications: 29

James C. Whisstock

James C. Whisstock

Monash University

Publications: 29

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