Kim Orth

Research.com Recognitions

• 2020 - Member of the National Academy of Sciences

Overview

Best Publications

• Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure.

  John Krupinski;Françoise Coussen;Françoise Coussen;Heather A. Bakalyar;Wei Jen Tang

  902
  Citations

• Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases.

  Arul M. Chinnaiyan;Kim A Orth;Karen O'Rourke;Hangjun Duan

  763
  Citations

• Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation

  Sohini Mukherjee;Gladys Keitany;Yan Li;Yong Wang

  751
  Citations

• Target Protease Specificity of the Viral Serpin CrmA ANALYSIS OF FIVE CASPASES

  Qiao Zhou;Scott Snipas;Kim Orth;Marta Muzio

  684
  Citations

• Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease.

  Kim Orth;Zhaohui Xu;Mary Beth Mudgett;Zhao Qin Bao

  684
  Citations

• Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

  Thomas E. Willnow;Joseph L Goldstein;Kim A Orth;Michael S Brown

  677
  Citations

• The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

  Kim A Orth;Arul M. Chinnaiyan;Manish Garg;Christopher J. Froelich

  604
  Citations

• A Transforming Growth Factor β Receptor Type II Gene Mutation Common in Colon and Gastric but Rare in Endometrial Cancers with Microsatellite Instability

  Lois L. Myeroff;Ramon Parsons;Seong Jin Kim;Lora Hedrick

  599
  Citations

• Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

  Bodo Levkau;Hidenori Koyama;Elaine W. Raines;Bruce E. Clurman

  584
  Citations

• New Paradigm for Lymphocyte Granule-mediated Cytotoxicity: TARGET CELLS BIND AND INTERNALIZE GRANZYME B, BUT AN ENDOSOMOLYTIC AGENT IS NECESSARY FOR CYTOSOLIC DELIVERY AND SUBSEQUENT APOPTOSIS *

  Christopher J. Froelich;Kim A Orth;Jane Turbov;Prem Seth

  541
  Citations

• Inhibition of the Mitogen-Activated Protein Kinase Kinase Superfamily by a Yersinia Effector

  Kim Orth;Lance E. Palmer;Zhao Qin Bao;Scott Stewart

  519
  Citations

• Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis

  Long Ping Wen;Jimothy A. Fahrni;Sergiu Troie;Jun Lin Guan

  486
  Citations

• AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

  Melanie L. Yarbrough;Yan Li;Lisa N. Kinch;Nick V. Grishin

  482
  Citations

• Vibrio parahaemolyticus cell biology and pathogenicity determinants.

  Christopher A. Broberg;Thomas J. Calder;Kim Orth

  442
  Citations

• ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

  Hangjun Duan;Kim A Orth;Arul M. Chinnaiyan;Guy G. Poirier

  412
  Citations

• Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/α2-macroglobulin receptor

  Kim Orth;Edwin L. Madison;Mary Jane Gething;Mary Jane Gething;Joseph F. Sambrook

  346
  Citations

• Cutting Edge: Salmonella AvrA Effector Inhibits the Key Proinflammatory, Anti-Apoptotic NF-κB Pathway

  Lauren S. Collier-Hyams;Hui Zeng;Jun Sun;Amelia D. Tomlinson

  341
  Citations

• Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta.

  Andrew Hotson;Renee Chosed;Hongjun Shu;Kim A Orth

  320
  Citations

• A distinctive role for the Yersinia protein kinase: Actin binding, kinase activation, and cytoskeleton disruption

  Stephen J. Juris;Amy E. Rudolph;Amy E. Rudolph;Don Huddler;Kim Orth

  294
  Citations

• Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases

  Kim Orth;Karen O'Rourke;Guy S. Salvesen;Vishva M. Dixit

  268
  Citations