Scott H. Kaufmann

Overview

Best Publications

• Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

  William C. Earnshaw;Luis M. Martins;Scott H. Kaufmann

  3967
  Citations

• Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

  Y. A. Lazebnik;S. H. Kaufmann;S. Desnoyers;G. G. Poirier

  3310
  Citations

• Specific Proteolytic Cleavage of Poly(ADP-ribose) Polymerase: An Early Marker of Chemotherapy-induced Apoptosis

  Scott H. Kaufmann;Serge Desnoyers;Yvonne Ottaviano;Nancy E. Davidson

  2555
  Citations

• Induction of apoptosis by cancer chemotherapy.

  Scott H. Kaufmann;William C. Earnshaw

  1704
  Citations

• PARP inhibition: PARP1 and beyond

  Michèle Rouleau;Anand Patel;Michael J. Hendzel;Scott H. Kaufmann

  1565
  Citations

• Induction of Endonucleolytic DNA Cleavage in Human Acute Myelogenous Leukemia Cells by Etoposide, Camptothecin, and Other Cytotoxic Anticancer Drugs: A Cautionary Note

  Scott H. Kaufmann

  1336
  Citations

• Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial

  Elizabeth M Swisher;Kevin K Lin;Amit M Oza;Clare L Scott

  1159
  Citations

• Programmed cell death: alive and well in the new millennium.

  Scott H. Kaufmann;Michael O. Hengartner

  915
  Citations

• Cathepsin B contributes to TNF-α–mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

  M. Eugenia Guicciardi;Jan Deussing;Hideyuki Miyoshi;Steven F. Bronk

  907
  Citations

• The Current Status of Camptothecin Analogues as Antitumor Agents

  William J. Slichenmyer;Eric K. Rowinsky;Ross C. Donehower;Scott H. Kaufmann

  794
  Citations

• Caspases and caspase inhibitors.

  Pascal Villa;Scott H. Kaufmann;William C. Earnshaw

  794
  Citations

• The role of proteases during apoptosis.

  Tushar Patel;Gregory J. Gores;Scott H. Kaufmann

  728
  Citations

• Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

  Yuri A. Lazebnik;Atsushi Takahashi;Robert D. Moir;Robert D. Goldman

  695
  Citations

• Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas

  William A. Faubion;M. Eugenia Guicciardi;Hideyuki Miyoshi;Steven F. Bronk

  651
  Citations

• Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

  Atsushi Takahashi;Emad S. Alnemri;Yuri A. Lazebnik;Yuri A. Lazebnik;Teresa Fernandes-Alnemri

  637
  Citations

• Phase II Trial of Single-Agent Temsirolimus (CCI-779) for Relapsed Mantle Cell Lymphoma

  Thomas E. Witzig;Susan M. Geyer;Irene Ghobrial;David J. Inwards

  630
  Citations

• PICKLE is a CHD3 chromatin-remodeling factor that regulates the transition from embryonic to vegetative development in Arabidopsis

  Joe Ogas;Scott Kaufmann;Jim Henderson;Chris Somerville

  602
  Citations

• Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial.

  Judith E. Karp;Jeffrey E. Lancet;Scott H. Kaufmann;David W. End

  595
  Citations

• Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells

  Anand G. Patel;Jann N. Sarkaria;Scott H. Kaufmann

  580
  Citations

• Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.

  E K Rowinsky;L B Grochow;C B Hendricks;D S Ettinger

  477
  Citations