Guy G. Poirier

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Best Publications

• Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

  Y. A. Lazebnik;S. H. Kaufmann;S. Desnoyers;G. G. Poirier

  3310
  Citations

• Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

  Muneesh Tewari;Long T Quan;Karen O'Rourke;Serge Desnoyers

  3048
  Citations

• Specific Proteolytic Cleavage of Poly(ADP-ribose) Polymerase: An Early Marker of Chemotherapy-induced Apoptosis

  Scott H. Kaufmann;Serge Desnoyers;Yvonne Ottaviano;Nancy E. Davidson

  2555
  Citations

• POLY(ADP-RIBOSYL)ATION REACTIONS IN THE REGULATION OF NUCLEAR FUNCTIONS

  Damien d'AMOURS;Serge Desnoyers;Icy d'SILVA;Guy G. Poirier

  2364
  Citations

• Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.

  Seong Woon Yu;Hongmin Wang;Marc F. Poitras;Carmen Coombs

  2308
  Citations

• PARP inhibition: PARP1 and beyond

  Michèle Rouleau;Anand Patel;Michael J. Hendzel;Scott H. Kaufmann

  1565
  Citations

• Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

  Seong-Woon Yu;Shaida A. Andrabi;Hongmin Wang;Hongmin Wang;No Soo Kim

  925
  Citations

• Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks.

  Tomas Lindahl;Masahiko S. Satoh;Guy G. Poirier;Arne Klungland

  823
  Citations

• Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases.

  Arul M. Chinnaiyan;Kim A Orth;Karen O'Rourke;Hangjun Duan

  763
  Citations

• Poly(ADP-ribose) (PAR) polymer is a death signal

  Shaida A. Andrabi;No Soo Kim;Seong-Woon Yu;Seong-Woon Yu;Hongmin Wang;Hongmin Wang

  750
  Citations

• Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

  Yuri A. Lazebnik;Atsushi Takahashi;Robert D. Moir;Robert D. Goldman

  695
  Citations

• PARP1-dependent Kinetics of Recruitment of MRE11 and NBS1 Proteins to Multiple DNA Damage Sites

  Jean-François Haince;Darin McDonald;Amélie Rodrigue;Ugo Déry

  689
  Citations

• Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure.

  G G Poirier;G de Murcia;J Jongstra-Bilen;C Niedergang

  687
  Citations

• Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

  Atsushi Takahashi;Emad S. Alnemri;Yuri A. Lazebnik;Yuri A. Lazebnik;Teresa Fernandes-Alnemri

  637
  Citations

• Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis.

  David K. Perry;Mirrian J. Smyth;Mirrian J. Smyth;Henning R. Stennicke;Guy S. Salvesen

  613
  Citations

• Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

  Marc Germain;El Bachir Affar;Damien D'Amours;Vishva M. Dixit

  556
  Citations

• ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase

  Homayoun Vaziri;Michael D. West;Richard C. Allsopp;Timothy S. Davison

  521
  Citations

• The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

  David R. Beidler;Muneesh Tewari;Paul D. Friesen;Guy Poirier

  518
  Citations

• Systematic Analysis of the Protein Interaction Network for the Human Transcription Machinery Reveals the Identity of the 7SK Capping Enzyme

  Célia Jeronimo;Diane Forget;Annie Bouchard;Qintong Li

  507
  Citations

• PARP-1, a determinant of cell survival in response to DNA damage

  Véronique J. Bouchard;Michèle Rouleau;Guy G. Poirier

  495
  Citations