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Alexander Bürkle

Alexander Bürkle

D-Index & Metrics

Molecular Biology

D-Index
71
Citations
14244
World Ranking
1391
National Ranking
102

Overview

Alexander Bürkle is affiliated with the University of Konstanz in Germany and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans multiple subfields including molecular biology, oncology, physiology, nutrition and dietetics, and cardiology and cardiovascular medicine.

Their research topics cover diverse areas such as:

  • PARP inhibition in cancer therapy
  • Spaceflight effects on biology
  • DNA repair mechanisms
  • Nutritional studies and diet
  • Integrated circuits and semiconductor failure analysis
  • Antioxidant activity and oxidative stress
  • Animal virus infections studies

Alexander Bürkle has published in a range of scientific venues, frequently contributing to:

  • GeroScience
  • The Journals of Gerontology Series A
  • Mechanisms of Ageing and Development
  • Toxicology Letters
  • Scientific Reports

Significant recent papers by Alexander Bürkle and colleagues include:

  • "Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains" (2021, Scientific Reports)
  • "Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy" (2020, Nature Communications)
  • "PARP1 catalytic variants reveal branching and chain length-specific functions of poly(ADP-ribose) in cellular physiology and stress response" (2020, Nucleic Acids Research)
  • "Long-term human spaceflight and inflammaging: Does it promote aging?" (2023, Ageing Research Reviews)
  • "Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study" (2021, Frontiers in Microbiology)

The scientist frequently collaborates with other researchers, including:

  • María Moreno-Villanueva
  • Miriam Capri
  • Claudio Franceschi
  • Tilman Grune
  • Efstathios S. Gonos

Best Publications

  • Physiology and pathophysiology of poly(ADP-ribosyl)ation.

    Alexander Bürkle

  • Poly(ADP‐ribose)

    Alexander Bürkle

  • Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span

    Karlheinz Grube;Alexander Burkle

  • Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms.

    A Hartwig;M Asmuss;I Ehleben;U Herzer

  • Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells

    Birgit Heller;Zhao-Qi Wang;Erwin F. Wagner;Jürgen Radons

  • DNA amplification of adeno-associated virus as a response to cellular genotoxic stress.

    Yalkinoglu Ao;Heilbronn R;Bürkle A;Schlehofer

  • Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

    M. Molinete;W. Vermeulen;A. Bürkle;J. Menissier-De Murcia

  • Lethal recessive myelin toxicity of prion protein lacking its central domain

    Frank Baumann;Markus Tolnay;Christine Brabeck;Jens Pahnke

  • Reconfiguration of DNA methylation in aging

    Michele Zampieri;Fabio Ciccarone;Roberta Calabrese;Claudio Franceschi

  • MARK-AGE biomarkers of ageing

    Alexander Bürkle;María Moreno-Villanueva;Jürgen Bernhard;María Blasco

  • Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion.

    J. Radons;B. Heller;A. Burkle;B. Hartmann

  • Stress, DNA damage and ageing -- an integrative approach.

    von Zglinicki T;Bürkle A;Kirkwood Tb

  • Poly(ADP-ribose): PARadigms and PARadoxes

    Alexander Bürkle;László Virág

  • Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

    Philip Wenzel;Swenja Schuhmacher;Joachim Kienhöfer;Johanna Müller

  • Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases

    Nathan A Berger;Valerie C Besson;A Hamid Boulares;Alexander Bürkle

  • Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length.

    Jörg Fahrer;Ramon Kranaster;Matthias Altmeyer;Andreas H Marx

  • Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability.

    A Hartwig;M Asmuss;H Blessing;S Hoffmann;S Hoffmann

  • Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians

    Marie-Laure Muiras;Marcus Müller;François Schächter;A. Bürkle

  • The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.

    R Heilbronn;A Bürkle;S Stephan;H zur Hausen

  • Overexpression of Nonconvertible PrP c Δ114–121 in Scrapie-Infected Mouse Neuroblastoma Cells Leads to trans-Dominant Inhibition of Wild-Type PrP Sc Accumulation

    Christina Hölscher;Hajo Delius;Alexander Bürkle

Frequent Co-Authors

Claudio Franceschi
Claudio Franceschi University of Bologna
Tilman Grune
Tilman Grune University of Potsdam
Ewa Sikora
Ewa Sikora Polish Academy of Sciences
Efstathios S. Gonos
Efstathios S. Gonos National Hellenic Research Foundation
Olivier Toussaint
Olivier Toussaint University of Namur
Beatrix Grubeck-Loebenstein
Beatrix Grubeck-Loebenstein University of Innsbruck
Miriam Capri
Miriam Capri University of Bologna
Marco Malavolta
Marco Malavolta Advanced Technology Center
Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
Claude Libert
Claude Libert Ghent University

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