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Jürgen A. Kleinschmidt

Jürgen A. Kleinschmidt

D-Index & Metrics

Molecular Biology

D-Index
71
Citations
16045
World Ranking
1382
National Ranking
101

Overview

Jürgen A. Kleinschmidt is affiliated with the German Cancer Research Center in Germany. Their research primarily focuses on virus-based gene therapy and intersects various aspects of medicine, biochemistry, genetics, and molecular biology.

Their work covers multiple topics including:

  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • Viral Infectious Diseases and Gene Expression in Insects
  • Interferon and immune responses
  • Ubiquitin and proteasome pathways
  • Systemic Sclerosis and Related Diseases
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Jürgen A. Kleinschmidt has been published predominantly in the following venues:

  • Journal of Virology
  • Arthritis & Rheumatology

The following selected papers illustrate some of their recent contributions:

  • "Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach" (2020), Journal of Virology
  • "SUMOylation Targets Adeno-associated Virus Capsids but Mainly Restricts Transduction by Cellular Mechanisms" (2020), Journal of Virology
  • "Adeno-Associated Virus Type 5 Infection via PDGFRα Is Associated With Interstitial Lung Disease in Systemic Sclerosis and Generates Composite Peptides and Epitopes Recognized by the Agonistic Immunoglobulins Present in Patients With Systemic Sclerosis" (2023), Arthritis & Rheumatology
  • "Correction for Gurda et al., 'Mapping a Neutralizing Epitope onto the Capsid of Adeno-Associated Virus Serotype 8'" (2025), Journal of Virology

Their frequent collaborators include researchers in the field contributing jointly on various projects, such as:

  • Mavis Agbandje-McKenna
  • Qingxin Chen
  • Martin Müller
  • L. Patrick Havlik
  • Katherine E. Simon

Kleinschmidt's subfields of study emphasize molecular biology and genetics while also engaging in epidemiology, immunology, and pathology. This interdisciplinary approach supports investigations of viral mechanisms and their relationship with human diseases, including systemic sclerosis and interstitial lung diseases.

Best Publications

  • Novel tools for production and purification of recombinant adenoassociated virus vectors.

    Dirk Grimm;Andrea Kern;Karola Rittner;Jürgen A. Kleinschmidt

  • Identification of a Heparin-Binding Motif on Adeno-Associated Virus Type 2 Capsids

    A. Kern;K. Schmidt;C. Leder;O. J. Müller

  • Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2.

    Anne Girod;Martin Ried;Christiane Wobus;Harald Lahm

  • Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors

    Oliver J Müller;Felix Kaul;Matthew D Weitzman;Renata Pasqualini

  • The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity.

    Anne Girod;Christiane E. Wobus;Zoltán Zádori;Martin Ried

  • A viral assembly factor promotes AAV2 capsid formation in the nucleolus

    Florian Sonntag;Kristin Schmidt;Jürgen A. Kleinschmidt

  • Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm

    Jan Michael Peters;Werner W. Franke;Jürgen A. Kleinschmidt

  • Monoclonal Antibodies against the Adeno-Associated Virus Type 2 (AAV-2) Capsid: Epitope Mapping and Identification of Capsid Domains Involved in AAV-2–Cell Interaction and Neutralization of AAV-2 Infection

    Christiane E. Wobus;Barbara Hügle-Dörr;Anne Girod;Gabriele Petersen

  • DNA helicase‐mediated packaging of adeno‐associated virus type 2 genomes into preformed capsids

    Jason A. King;Ralf Dubielzig;Dirk Grimm;Jürgen A. Kleinschmidt

  • Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'γ)2 antibody

    Jeffrey S. Bartlett;Jurgen Kleinschmidt;Richard C. Boucher;R. Jude Samulski

  • Adeno-Associated Virus Type 2 Capsids with Externalized VP1/VP2 Trafficking Domains Are Generated prior to Passage through the Cytoplasm and Are Maintained until Uncoating Occurs in the Nucleus

    Florian Sonntag;Svenja Bleker;Barbara Leuchs;Roger Fischer

  • Structural Features of the 26 S Proteasome Complex

    J. M. Peters;Z. Cejka;J. R. Harris;J. A. Kleinschmidt

  • Subcellular compartmentalization of adeno-associated virus type 2 assembly.

    A Wistuba;A Kern;S Weger;D Grimm

  • Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system.

    Wim T.J.M.C. Hermens;Olivier Ter Brake;Paul A. Dijkhuizen;Marc A.F. Sonnemans

  • Mutational Analysis of Narrow Pores at the Fivefold Symmetry Axes of Adeno-Associated Virus Type 2 Capsids Reveals a Dual Role in Genome Packaging and Activation of Phospholipase A2 Activity

    Svenja Bleker;Florian Sonntag;Jürgen A. Kleinschmidt

  • Co-existence of two different types of soluble histone complexes in nuclei of Xenopus laevis oocytes

    J. A. Kleinschmidt;E. Fortkamp;G. Krohne;H. Zentgraf

  • AAV capsid structure and cell interactions.

    Mavis Agbandje-McKenna;Jürgen Kleinschmidt

  • Enhancement of Capsid Gene Expression: Preparing the Human Papillomavirus Type 16 Major Structural Gene L1 for DNA Vaccination Purposes

    Christoph Leder;Jürgen A. Kleinschmidt;Carsten Wiethe;Martin Müller

  • Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2.

    D Grimm;A Kern;M Pawlita;F K Ferrari

  • A Conformational Change in the Adeno-Associated Virus Type 2 Capsid Leads to the Exposure of Hidden VP1 N Termini

    Stephanie Kronenberg;Bettina Böttcher;Claus W. von der Lieth;Svenja Bleker

Frequent Co-Authors

Dirk Grimm
Dirk Grimm Heidelberg University
Hugo A. Katus
Hugo A. Katus Heidelberg University
Werner W. Franke
Werner W. Franke German Cancer Research Center
Frederik Wenz
Frederik Wenz University of Freiburg
Martin Müller
Martin Müller German Cancer Research Center
Mavis Agbandje-McKenna
Mavis Agbandje-McKenna University of Florida
Christiane E. Wobus
Christiane E. Wobus University of Michigan–Ann Arbor
Lutz Gissmann
Lutz Gissmann German Cancer Research Center
Michael Pawlita
Michael Pawlita German Cancer Research Center
Michael Hallek
Michael Hallek University of Cologne

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