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Biology and Biochemistry

D-Index
71
Citations
17238
World Ranking
6678
National Ranking
3106

Overview

John A. Chiorini is affiliated with the National Institutes of Health in the United States. Their research spans multiple fields within biomedical science, focusing strongly on medicine and biochemistry, genetics, and molecular biology. The scientist has contributed to a substantial body of work, primarily investigating physiological processes, molecular biology mechanisms, immunology, infectious diseases, and genetics.

Their key research topics cover several specific areas. These include salivary gland disorders and functions, virus-based gene therapy research, galectins and cancer biology, inflammasome and immune disorders, dermatological and COVID-19 studies, COVID-19 clinical research studies, and SARS-CoV-2 and COVID-19 research.

John A. Chiorini has published extensively in a variety of scientific venues. Notable frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Molecular Therapy - Methods & Clinical Development
  • Annals of the Rheumatic Diseases
  • Arthritis & Rheumatology

The scientist's recent papers illustrate the diversity and focus of their research interests. These include:

  • SARS-CoV-2 infection of the oral cavity and saliva, 2021, Nature Medicine
  • Autophagy as a modulator of cell death machinery, 2020, Cell Death and Disease
  • Enteric viruses replicate in salivary glands and infect through saliva, 2022, Nature
  • LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization, 2021, Autophagy
  • LAMP3 induces apoptosis and autoantigen release in Sjögren's syndrome patients, 2020, Scientific Reports

The scientist collaborates regularly with several co-authors. Frequent collaborators include:

  • Blake M. Warner
  • Hiroyuki Nakamura
  • Peter D. Burbelo
  • Tsutomu Tanaka
  • Sandra Afione

Best Publications

  • Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system

    Beverly L. Davidson;Colleen S. Stein;Jason A. Heth;Inês Martins

  • The family Parvoviridae

    Susan F. Cotmore;Mavis Agbandje-McKenna;John A. Chiorini;Dmitry V. Mukha

  • SARS-CoV-2 infection of the oral cavity and saliva.

    Ni Huang;Paola Pérez;Takafumi Kato;Yu Mikami

  • Adeno-Associated Virus Serotype 4 (AAV4) and AAV5 Both Require Sialic Acid Binding for Hemagglutination and Efficient Transduction but Differ in Sialic Acid Linkage Specificity

    Nikola Kaludov;Kevin E. Brown;Robert W. Walters;Joseph Zabner

  • Identification of PDGFR as a receptor for AAV-5 transduction

    Giovanni Di Pasquale;Beverly L Davidson;Colleen S Stein;Inês Martins

  • Cloning and Characterization of Adeno-Associated Virus Type 5

    John A. Chiorini;Frank Kim;Linda Yang;Robert M. Kotin

  • ICTV Virus Taxonomy Profile: Parvoviridae.

    Susan F. Cotmore;Mavis Agbandje-McKenna;Marta Canuti;John A. Chiorini

  • Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer.

    Robert W. Walters;Su Min P. Yi;Shaf Keshavjee;Kevin E. Brown

  • T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

    Andrew S Kondratowicz;Nicholas J Lennemann;Patrick L Sinn;Robert A Davey

  • Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

    Joseph Zabner;Michael Seiler;Robert Walters;Robert M. Kotin

  • Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles.

    John A. Chiorini;Linda Yang;Yuejiang Liu;Brian Safer

  • Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatography.

    Nikola Kaludov;Beverly Handelman;John A. Chiorini

  • Structurally mapping the diverse phenotype of adeno-associated virus serotype 4

    Lakshmanan Govindasamy;Eric Padron;Robert McKenna;Nicholas Muzyczka

  • Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment.

    Frederick B. Vivino;Vatinee Y. Bunya;Giacomina Massaro-Giordano;Chadwick R. Johr

  • Adeno-Associated Virus Type 12 (AAV12): a Novel AAV Serotype with Sialic Acid- and Heparan Sulfate Proteoglycan-Independent Transduction Activity

    Michael Schmidt;Antonis Voutetakis;Sandra Afione;Changyu Zheng

  • Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.

    Bruce J. Baum;Ilias Alevizos;Changyu Zheng;Ana P. Cotrim

  • High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors.

    John A. Chiorini;Clemens M. Wendtner;Elena Urcelay;Brian Safer

  • Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors.

    Joseph M. Alisky;Stephanie M. Hughes;Sybille L. Sauter;Douglas Jolly

  • Functional Correction of CNS Phenotypes in a Lysosomal Storage Disease Model Using Adeno-Associated Virus Type 4 Vectors

    Gumei Liu;Inês Martins;John A. Wemmie;John A. Chiorini

  • Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli.

    J A Chiorini;M D Weitzman;R A Owens;E Urcelay

Frequent Co-Authors

Mavis Agbandje-McKenna
Mavis Agbandje-McKenna University of Florida
Bruce J. Baum
Bruce J. Baum National Institutes of Health
Gabor G. Illei
Gabor G. Illei Horizon Therapeutics
Paul P. Tak
Paul P. Tak GlaxoSmithKline (United Kingdom)
Robert McKenna
Robert McKenna University of Florida
Brian Safer
Brian Safer National Institutes of Health
Nicholas Muzyczka
Nicholas Muzyczka University of Florida
Robert M. Kotin
Robert M. Kotin University of Massachusetts Chan Medical School
Joseph Zabner
Joseph Zabner University of Iowa
Beverly L. Davidson
Beverly L. Davidson Children's Hospital of Philadelphia

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