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Biology and Biochemistry

D-Index
56
Citations
12767
World Ranking
14316
National Ranking
6033

Overview

Aravind Asokan is a researcher affiliated with Duke University in the United States. Their scientific contributions span the fields of biochemistry, genetics, and molecular biology, with a significant focus also on medicine. Their work addresses multiple specialized areas including molecular biology, genetics, cardiology and cardiovascular medicine, epidemiology, and surgery.

Their primary research topics include virus-based gene therapy research, CRISPR and genetic engineering, RNA interference and gene delivery, viral infections and immunology research, CAR-T cell therapy research, viral infectious diseases and gene expression in insects, and RNA regulation and disease.

They have published extensively, with notable recent papers including:

  • Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme, 2020, JCI Insight
  • The NIH Somatic Cell Genome Editing program, 2021, Nature
  • Transgenic mice for in vivo epigenome editing with CRISPR-based systems, 2021, Nature Methods
  • Intravital imaging of mouse embryos, 2020, Science
  • An evolved AAV variant enables efficient genetic engineering of murine T cells, 2023, Cell

They frequently collaborate with other researchers including Trevor Gonzalez, Garth Devlin, Alan Rosales, Zachary C. Elmore, and Charles A. Gersbach.

Their publications appear in several venues, with the greatest number of contributions in:

  • UNC Libraries
  • Journal of Virology
  • Nature Communications
  • Molecular Therapy
  • Molecular Genetics and Metabolism

Best Publications

  • In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

    Christopher E. Nelson;Chady H. Hakim;David G. Ousterout;Pratiksha I. Thakore

  • Adeno-associated virus serotypes: vector toolkit for human gene therapy.

    Zhijian Wu;Aravind Asokan;R. Jude Samulski

  • Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

    Humberto Mestre;Lauren M. Hablitz;Anna L.R. Xavier;Weixi Feng

  • The AAV Vector Toolkit: Poised at the Clinical Crossroads

    Aravind Asokan;David V Schaffer;David V Schaffer;R Jude Samulski

  • Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy

    Christopher E. Nelson;Yaoying Wu;Matthew P. Gemberling;Matthew L. Oliver

  • Terminal N-Linked Galactose Is the Primary Receptor for Adeno-associated Virus 9

    Shen Shen;Kelli D. Bryant;Sarah M. Brown;Scott H. Randell

  • Optical Control of CRISPR/Cas9 Gene Editing.

    James Hemphill;Erin K. Borchardt;Kalyn Brown;Aravind Asokan

  • Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles

    Wuping Li;Aravind Asokan;Zhijian Wu;Terry Van Dyke

  • Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle

    Aravind Asokan;Julia C. Conway;Jana L. Phillips;Chengwen Li

  • Single Amino Acid Changes Can Influence Titer, Heparin Binding, and Tissue Tropism in Different Adeno-Associated Virus Serotypes

    Zhijian Wu;Aravind Asokan;Joshua C. Grieger;Lakshmanan Govindasamy

  • Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer.

    Nagesh Pulicherla;Shen Shen;Swati Yadav;Kari Debbink

  • Adeno-Associated Virus Type 2 Contains an Integrin α5β1 Binding Domain Essential for Viral Cell Entry

    Aravind Asokan;Julie B. Hamra;Lakshmanan Govindasamy;Mavis Agbandje-McKenna

  • Production of Recombinant Adeno-Associated Viral Vectors

    Vivian W. Choi;Aravind Asokan;Rebecca A. Haberman;Richard Jude Samulski

  • Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia.

    Chengwen Li;N. Narkbunnam;N. Narkbunnam;Richard J Samulski;Aravind Asokan

  • Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion

    Longping Victor Tse;Kelli A. Klinc;Victoria J. Madigan;Ruth M. Castellanos Rivera

  • Biology of adeno-associated viral vectors in the central nervous system.

    Giridhar Murlidharan;Richard J. Samulski;Aravind Asokan

  • Exploitation of intracellular pH gradients in the cellular delivery of macromolecules.

    Aravind Asokan;Moo J. Cho

  • Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry.

    Elizabeth E. Pierson;David. Z. Keifer;Aravind Asokan;Martin F. Jarrold

  • Biophysical and Ultrastructural Characterization of Adeno-Associated Virus Capsid Uncoating and Genome Release

    Eric D. Horowitz;K. Shefaet Rahman;Brian D. Bower;David J. Dismuke

  • In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

    C. E. Nelson;C. H. Hakim;D. G. Ousterout;P. I. Thakore

Frequent Co-Authors

Richard J. Samulski
Richard J. Samulski University of North Carolina at Chapel Hill
Mavis Agbandje-McKenna
Mavis Agbandje-McKenna University of Florida
Charles A. Gersbach
Charles A. Gersbach Duke University
Robert McKenna
Robert McKenna University of Florida
William F. Marzluff
William F. Marzluff University of North Carolina at Chapel Hill
Jonah B. Sacha
Jonah B. Sacha Oregon Health & Science University
Yasuhiro Ikeda
Yasuhiro Ikeda AstraZeneca (United Kingdom)
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Steven J.M. Jones
Steven J.M. Jones University of British Columbia

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