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Hildegard Büning

Hildegard Büning

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
10956
World Ranking
16097
National Ranking
1127

Overview

Hildegard Büning is affiliated with the Hannover Medical School in Germany and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work predominantly spans molecular biology and genetics, with additional focus on oncology, immunology, and hepatology as subfields of study.

The scientist's research topics cover a range of areas related to gene therapy and molecular techniques. These include virus-based gene therapy research, CRISPR and genetic engineering, CAR-T cell therapy research, RNA interference and gene delivery, viral infectious diseases and gene expression in insects, liver physiology and pathology, and retinal development and disorders.

They have published in several frequent venues: Human Gene Therapy, Molecular Therapy, Molecular Therapy - Methods & Clinical Development, Journal of Hepatology, and bioRxiv (Cold Spring Harbor Laboratory).

Recent notable papers by Hildegard Büning include:

  • Use of Cell and Genome Modification Technologies to Generate Improved "Off-the-Shelf" CAR T and CAR NK Cells, 2020, Frontiers in Immunology
  • Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders, 2021, EMBO Molecular Medicine
  • A new age of precision gene therapy, 2023, The Lancet
  • Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives, 2020, Cancers
  • A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism, 2020, Nature Communications

Frequent co-authors collaborating with Büning include Axel Schambach, Michael Morgan, Ulrich Hacker, Nadja Meumann, and Michael Ott.

Best Publications

  • Real-time single-molecule imaging of the infection pathway of an adeno-associated virus.

    Georg Seisenberger;Martin U. Ried;Thomas Endreß;Hildegard Büning

  • Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.

    Marianna Hösel;Maria Quasdorff;Katja Wiegmann;Dennis Webb

  • Gene therapy on the move

    Kerstin B. Kaufmann;Hildegard Büning;Anne Galy;Axel Schambach;Axel Schambach

  • In vitro selection of viral vectors with modified tropism: the adeno-associated virus display.

    Luca Perabo;Hildegard Büning;David M Kofler;Martin U Ried

  • HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

    Joshua A. Horwitz;Ariel Halper-Stromberg;Hugo Mouquet;Alexander D. Gitlin

  • In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration.

    Florence M. Bareyre;Natalie Garzorz;Claudia Lang;Thomas Misgeld

  • Recent developments in adeno‐associated virus vector technology

    Hildegard Büning;Luca Perabo;Oliver Coutelle;Sibille Quadt-Humme

  • Targeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectors.

    Stephen J. White;Stuart A. Nicklin;Hildegard Büning;M. Julia Brosnan

  • Green fluorescent protein-tagged adeno-associated virus particles allow the study of cytosolic and nuclear trafficking.

    Kerstin Lux;Nico Goerlitz;Stefanie Schlemminger;Luca Perabo

  • Capsid Modifications for Targeting and Improving the Efficacy of AAV Vectors

    Hildegard Büning;Arun Srivastava

  • Receptor targeting of adeno-associated virus vectors.

    H Büning;M U Ried;L Perabo;F M Gerner

  • Restoration of Cone Vision in the CNGA3−/− Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function

    Stylianos Michalakis;Regine Mühlfriedel;Naoyuki Tanimoto;Vidhyasankar Krishnamoorthy

  • Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

    Robert C Münch;Hanna Janicki;Iris Völker;Anke Rasbach

  • A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses

    Andreas Neerincx;Katja Lautz;Maureen Menning;Elisabeth Kremmer

  • Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virus.

    Luca Perabo;Jan Endell;Jan Endell;Susan King;Kerstin Lux

  • Adeno-Associated Virus Capsids Displaying Immunoglobulin-Binding Domains Permit Antibody-Mediated Vector Retargeting to Specific Cell Surface Receptors

    Martin U. Ried;Anne Girod;Kristin Leike;Hildegard Büning

  • Genetic modifications of the adeno-associated virus type 2 capsid reduce the affinity and the neutralizing effects of human serum antibodies

    N A Huttner;A Girod;L Perabo;D Edbauer

  • Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

    Marianna Hösel;Mathias Broxtermann;Hanna Janicki;Knud Esser

  • Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses.

    Lorraine M. Work;Hildegard Büning;Ela Hunt;Stuart A. Nicklin

  • Development of Efficient Viral Vectors Selective for Vascular Smooth Muscle Cells

    Lorraine M Work;Stuart A Nicklin;Nick J.R Brain;Kate L Dishart

Frequent Co-Authors

Michael Hallek
Michael Hallek University of Cologne
Axel Schambach
Axel Schambach Hannover Medical School
Stuart A. Nicklin
Stuart A. Nicklin University of Glasgow
Andy Baker
Andy Baker University of New South Wales
Martin Biel
Martin Biel Ludwig-Maximilians-Universität München
Dirk Grimm
Dirk Grimm Heidelberg University
Christian J. Buchholz
Christian J. Buchholz Paul Ehrlich Institut
Mathias Ackermann
Mathias Ackermann University of Zurich
Andrew H. Baker
Andrew H. Baker University of Edinburgh
Thilo Dörk
Thilo Dörk Hannover Medical School

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