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Christian J. Buchholz

Christian J. Buchholz

D-Index & Metrics

Molecular Biology

D-Index
47
Citations
7692
World Ranking
2752
National Ranking
188

Overview

Christian J. Buchholz is affiliated with the Paul Ehrlich Institut in Germany. Their research spans multiple domains within biochemistry, genetics, molecular biology, and medicine, with a significant focus on oncology, molecular biology, genetics, immunology, and biomedical engineering.

The scientist's main research topics include:

  • CAR-T cell therapy research
  • Virus-based gene therapy research
  • Viral Infectious Diseases and Gene Expression in Insects
  • RNA Interference and Gene Delivery
  • CRISPR and Genetic Engineering
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses

Christian J. Buchholz has contributed to several publication venues, with most frequent contributions in:

  • Molecular Therapy - Methods & Clinical Development
  • Schwäbische Heimat
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Therapy
  • Regular and Young Investigator Award Abstracts

Among their recent publications are the following papers, listed with the full title, year of publication, and venue:

  • In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes, 2020, Molecular Therapy
  • Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy, 2022, Immunity
  • A new age of precision gene therapy, 2023, The Lancet
  • Precision medicine: In vivo CAR therapy as a showcase for receptor-targeted vector platforms, 2022, Molecular Therapy
  • Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8, 2021, Molecular Therapy - Methods & Clinical Development

Christian J. Buchholz has frequently collaborated with multiple co-authors who have contributed extensively to related research areas. These frequent co-authors include:

  • Frederic B. Thalheimer
  • Naphang Ho
  • Elham Adabi
  • Jessica Hartmann
  • Alexander Michels

Best Publications

  • Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

    Jessica Hartmann;Martina Schüßler‐Lenz;Attilio Bondanza;Christian J Buchholz

  • The Secreted -Amyloid Precursor Protein Ectodomain APPs Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice

    Sabine Ring;Sascha W. Weyer;Susanne B. Kilian;Elaine Waldron

  • Measles Virus Spread and Pathogenesis in Genetically Modified Mice

    Branka Mrkic;Jovan Pavlovic;Thomas Rülicke;Pietro Volpe

  • Targeted Cell Entry of Lentiviral Vectors

    Sabrina Funke;Andrea Maisner;Michael D Mühlebach;Ulrike Koehl

  • Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

    Robert C Münch;Hanna Janicki;Iris Völker;Anke Rasbach

  • Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1.

    J. Stitz;C.J. Buchholz;M. Engelstädter;W. Uckert

  • Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors

    Brigitte Anliker;Tobias Abel;Sabrina Kneissl;Juraj Hlavaty

  • Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.

    Romain Fol;Romain Fol;Romain Fol;Jerome Braudeau;Jerome Braudeau;Susann Ludewig;Tobias Abel

  • DARPins: An Efficient Targeting Domain for Lentiviral Vectors

    Robert C Münch;Michael D Mühlebach;Thomas Schaser;Sabrina Kneissl

  • Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery.

    Christian J. Buchholz;Thorsten Friedel;Hildegard Büning

  • Specific Elimination of CD133+ Tumor Cells with Targeted Oncolytic Measles Virus

    Patricia Bach;Tobias Abel;Christopher Hoffmann;Zoltan Gal

  • Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors

    Robert C. Münch;Anke Muth;Alexander Muik;Thorsten Friedel

  • Preferential initiation at the second AUG of the measles virus F mRNA: a role for the long untranslated region

    Toni Cathomen;Christian J. Buchholz;Pius Spielhofer;Roberto Cattaneo

  • Oncolytic Efficacy and Enhanced Safety of Measles Virus Activated by Tumor-Secreted Matrix Metalloproteinases

    Christoph Springfeld;Veronika von Messling;Veronika von Messling;Marie Frenzke;Guy Ungerechts

  • Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

    N Milosch;G Tanriöver;A Kundu;A Rami

  • Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

    Ruben R. Bender;Anke Muth;Irene C. Schneider;Thorsten Friedel

  • Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition

    Max C Richter;Susann Ludewig;Alex Winschel;Tobias Abel

  • Circumventing Tolerance to the Prion Protein (PrP): Vaccination with PrP-Displaying Retrovirus Particles Induces Humoral Immune Responses against the Native Form of Cellular PrP

    Daphne Nikles;Patricia Bach;Klaus Boller;Christoph A. Merten

  • Measles virus spread by cell-cell contacts: uncoupling of contact-mediated receptor (CD46) downregulation from virus uptake.

    Ruth Firsching;Christian J. Buchholz;Urs Schneider;Roberto Cattaneo

  • T-cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing

    Qi Zhou;Irene C. Schneider;Inan Edes;Annemarie Honegger

Frequent Co-Authors

Roberto Cattaneo
Roberto Cattaneo Mayo Clinic
Winfried S. Wels
Winfried S. Wels Goethe University Frankfurt
Els Verhoeyen
Els Verhoeyen Inserm : Institut national de la santé et de la recherche médicale
Ulrich Kalinke
Ulrich Kalinke Hannover Medical School
Ulrike Müller
Ulrike Müller Heidelberg University
Andreas Plückthun
Andreas Plückthun University of Zurich
Mary Collins
Mary Collins Queen Mary University of London
Hildegard Büning
Hildegard Büning Hannover Medical School
Jürgen Schneider-Schaulies
Jürgen Schneider-Schaulies University of Würzburg

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