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Microbiology

D-Index
68
Citations
16559
World Ranking
2162
National Ranking
159

Overview

Winfried S. Wels is affiliated with Goethe University Frankfurt in Germany. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, with a specialized emphasis on Immunology and Oncology. Other subfields include Genetics, Molecular Biology, and Pulmonary and Respiratory Medicine.

The main topics covered in their work comprise:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • Virus-based gene therapy research
  • RNA Interference and Gene Delivery
  • Glioma Diagnosis and Treatment

Frequent co-authors in Wels's research include:

  • Torsten Tonn (22 publications)
  • Evelyn Ullrich (17 publications)
  • Michael C. Burger (14 publications)
  • F Straßheimer (13 publications)
  • Joachim P. Steinbach (11 publications)

Publishing venues where Wels has appeared multiple times include:

  • Neuro-Oncology (12 publications)
  • Frontiers in Immunology (7 publications)
  • Klinische Pädiatrie (7 publications)
  • Journal for ImmunoTherapy of Cancer (4 publications)
  • Cytotherapy (4 publications)

Notable recent papers authored or coauthored by Wels cover topics related to CAR-T cells, natural killer cells, and glioblastoma treatment. These papers include:

  • "Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma," 2020, Nature Communications
  • "High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia," 2020, Frontiers in Immunology
  • "Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma," 2023, Neuro-Oncology
  • "'UniCAR'-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells," 2020, Scientific Reports
  • "HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial," 2020, UNC Libraries

Best Publications

  • Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

    Nabil Ahmed;Vita S. Brawley;Meenakshi Hegde;Catherine Robertson

  • HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial

    Nabil Ahmed;Nabil Ahmed;Vita Brawley;Vita Brawley;Meenakshi Hegde;Meenakshi Hegde;Kevin Bielamowicz

  • Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

    Meenakshi Hegde;Malini Mukherjee;Malini Mukherjee;Zakaria Grada;Antonella Pignata

  • TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

    Zakaria Grada;Zakaria Grada;Meenakshi Hegde;Meenakshi Hegde;Tiara Byrd;Tiara Byrd;Donald R Shaffer;Donald R Shaffer

  • ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

    Congcong Zhang;Michael C. Burger;Lukas Jennewein;Sabrina Genßler

  • NK-92: an ‘off-the-shelf therapeutic’ for adoptive natural killer cell-based cancer immunotherapy

    Garnet Suck;Marcus Odendahl;Paulina Nowakowska;Christian Seidl

  • Retargeting of natural killer–cell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction

    Christoph Uherek;Torsten Tonn;Barbara Uherek;Sven Becker

  • Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor

    Kurt Schönfeld;Christiane Sahm;Congcong Zhang;Sonja Naundorf

  • Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cells.

    Dirk Moritz;Winfried Wels;Jurgen Mattern;Bernd Groner

  • 3D model for CAR-mediated cytotoxicity using patient-derived colorectal cancer organoids

    Theresa E Schnalzger;Theresa E Schnalzger;Marnix Hp de Groot;Congcong Zhang;Congcong Zhang;Mohammed H Mosa

  • Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity.

    Congcong Zhang;Pranav Oberoi;Sarah Oelsner;Anja Waldmann

  • Expression of a CD20-specific chimeric antigen receptor enhances cytotoxic activity of NK cells and overcomes NK-resistance of lymphoma and leukemia cells

    Tina Müller;Christoph Uherek;Guitta Maki;Kai Uwe Chow

  • CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies

    Annette Romanski;Christoph Uherek;Gesine Bug;Erhard Seifried

  • Advantages and applications of CAR-expressing natural killer cells.

    Wolfgang Glienke;Ruth Esser;Christoph Priesner;Julia D. Suerth

  • Intracellular expression of single chain antibodies reverts ErbB-2 transformation

    R R Beerli;W Wels;N E Hynes

  • Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody-dependent cellular cytotoxicity.

    Laurent Boissel;Monica Betancur-Boissel;Weiquan Lu;Daniela S Krause

  • Construction, bacterial expression and characterization of a bifunctional single-chain antibody-phosphatase fusion protein targeted to the human erbB-2 receptor.

    Winfried Wels;Ina-Maria Harwerth;Marcus Zwickl;Norman Hardman

  • Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor.

    Christiane Sahm;Kurt Schönfeld;Winfried S. Wels

  • Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression.

    Nabil Ahmed;Vita S Salsman;Vita S Salsman;Eric Yvon;Eric Yvon;Chrystal U Louis;Chrystal U Louis

  • Monoclonal antibodies against the extracellular domain of the erbB-2 receptor function as partial ligand agonists

    I M Harwerth;W Wels;B M Marte;N E Hynes

  • METHODS: ORIGINAL ARTICLE TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

    Zakaria Grada;Meenakshi Hegde;Tiara Byrd;Donald R Shaffer

Frequent Co-Authors

Torsten Tonn
Torsten Tonn TU Dresden
Stephen Gottschalk
Stephen Gottschalk St. Jude Children's Research Hospital
Bernd Groner
Bernd Groner Goethe University Frankfurt
Gianpietro Dotti
Gianpietro Dotti University of North Carolina at Chapel Hill
Peter Bader
Peter Bader Goethe University Frankfurt
Helen E. Heslop
Helen E. Heslop Baylor College of Medicine
Halvard Bonig
Halvard Bonig Goethe University Frankfurt
Christian J. Buchholz
Christian J. Buchholz Paul Ehrlich Institut
Cliona M. Rooney
Cliona M. Rooney Baylor College of Medicine
Nancy E. Hynes
Nancy E. Hynes Friedrich Miescher Institute

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