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Biology and Biochemistry
Switzerland
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
39147
World Ranking
2508
National Ranking
54

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

Nancy E. Hynes is affiliated with the Friedrich Miescher Institute in Switzerland. Their research contributions span multiple fields, with a focus on medicine and biochemistry, genetics, and molecular biology. The scientist has a notable emphasis on subfields including molecular biology, cancer research, oncology, nephrology, and surgery.

Their research interests cover a range of biomedical topics such as renal and related cancers, parathyroid disorders and treatments, microRNA in disease regulation, genetic and kidney cyst diseases, biomedical research and pathophysiology, birth, development, and health, as well as breast implant and reconstruction.

Among the recent publications authored or co-authored by Nancy E. Hynes are:

  • Knowledge gaps in oncoplastic breast surgery (2020), published in The Lancet Oncology
  • Ret Receptor Has Distinct Alterations and Functions in Breast Cancer (2020), published in Journal of Mammary Gland Biology and Neoplasia
  • Elevated serum magnesium lowers calcification propensity in Memo1-deficient mice (2020), published in PLoS ONE
  • Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity (2022), published in Journal of Cell Communication and Signaling
  • Aberrant RET expression affects normal mammary gland post-lactation transition, enhancing cancer potential (2022), published in Disease Models & Mechanisms

Frequent co-authors collaborating with Nancy E. Hynes include:

  • Matthias B. Moor
  • Suresh Krishna Ramakrishnan
  • Olivier Bonny
  • Katalin Bartos
  • Sophie Braga-Lagache

Key publication venues for Nancy E. Hynes encompass:

  • Zenodo (CERN European Organization for Nuclear Research)
  • The Lancet Oncology
  • Journal of Mammary Gland Biology and Neoplasia
  • PLoS ONE
  • Journal of Cell Communication and Signaling

Nancy E. Hynes's scientific output reflects engagement with complex biomedical issues, particularly related to cancer biology and kidney function. Their work contributes to understanding molecular mechanisms in disease and potential therapeutic paths across oncology, nephrology, and surgical disciplines.

Best Publications

  • ERBB receptors and cancer: the complexity of targeted inhibitors.

    Nancy E. Hynes;Heidi A. Lane

  • The ErbB signaling network: receptor heterodimerization in development and cancer

    Monilola A. Olayioye;Richard M. Neve;Heidi A. Lane;Nancy E. Hynes

  • ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

    Diana Graus‐Porta;Roger R. Beerli;John M. Daly;Nancy E. Hynes

  • The biology of erbB-2/neu/HER-2 and its role in cancer.

    Nancy E. Hynes;David F. Stern

  • ErbB receptors and signaling pathways in cancer

    Nancy E Hynes;Gwen MacDonald

  • The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

    Thomas Holbro;Roger R. Beerli;Francisca Maurer;Magdalena Koziczak

  • Recombinant antibodies specific for a growth factor receptor

    Winfried Stephan Dr. Wels;Nancy E. Dr. Hynes;Ina-Maria Harwerth;Bernd Dr. Groner

  • The ErbB receptors and their role in cancer progression.

    Thomas Holbro;Gianluca Civenni;Nancy E Hynes

  • ErbB Receptors: Directing Key Signaling Networks Throughout Life

    Thomas Holbro;Nancy E. Hynes

  • Correlation of c-erbB-2 Gene Amplification and Protein Expression in Human Breast Carcinoma with Nodal Status and Nuclear Grading

    Mark S. Berger;Gottfried W. Locher;Susanne Saurer;William J. Gullick

  • The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors

    Leah N. Klapper;Stefanie Glathe;Nora Vaisman;Nancy E. Hynes

  • ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases.

    Monilola A. Olayioye;Iwan Beuvink;Kay Horsch;John M. Daly

  • ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency.

    Heidi A. Lane;Iwan Beuvink;Andrea B. Motoyama;John M. Daly

  • Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities

    Roger R. Beerli;Nancy E. Hynes

  • Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling.

    D Graus-Porta;R R Beerli;N E Hynes

  • ErbB-1 and ErbB-2 Acquire Distinct Signaling Properties Dependent upon Their Dimerization Partner

    Monilola A. Olayioye;Diana Graus-Porta;Roger R. Beerli;Jack Rohrer

  • The Efficacy of ErbB Receptor-targeted Anticancer Therapeutics Is Influenced by the Availability of Epidermal Growth Factor-related Peptides

    Andrea B Motoyama;Nancy E Hynes;Heidi A Lane

  • Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis.

    Lily Yen;Xiao-Li You;Ala-Eddin Al Moustafa;Gerald Batist

  • Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation

    Thomas Schlange;Yutaka Matsuda;Susanne Lienhard;Alexandre Huber;Alexandre Huber

  • Correction: ERBB Receptors and Cancer: The Complexity of Targeted Inhibitors

    Nancy E. Hynes;Heidi A. Lane

Frequent Co-Authors

Bernd Groner
Bernd Groner Goethe University Frankfurt
Winfried S. Wels
Winfried S. Wels Goethe University Frankfurt
Helmut Ponta
Helmut Ponta Karlsruhe Institute of Technology
Yosef Yarden
Yosef Yarden Weizmann Institute of Science
Giorgio R. Merlo
Giorgio R. Merlo University of Turin
T. Keith Blackwell
T. Keith Blackwell Harvard University
William J. Gullick
William J. Gullick University of Kent
Charles H. Streuli
Charles H. Streuli University of Manchester
David S. Salomon
David S. Salomon National Institutes of Health
Ruth Chiquet-Ehrismann
Ruth Chiquet-Ehrismann Friedrich Miescher Institute

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