World's Best Scientists 2026 revealed!
T. Keith Blackwell

T. Keith Blackwell

D-Index & Metrics

Molecular Biology

D-Index
57
Citations
18695
World Ranking
2127
National Ranking
1056

Overview

T. Keith Blackwell is affiliated with Harvard University in the United States and has contributed extensively to the field of biochemistry, genetics, and molecular biology. Their research spans several related disciplines with a focus on molecular biology, aging, endocrine and autonomic systems, physiology, and cell biology.

The scientist's work prominently covers topics including genetics, aging, and longevity in model organisms, genomics, phytochemicals, and oxidative stress, circadian rhythm and melatonin, adipose tissue and metabolism, endoplasmic reticulum stress and disease, mitochondrial function and pathology, as well as ubiquitin and proteasome pathways.

Notable recent publications include:

  • Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans, 2021, Nature Communications
  • ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1, 2022, Nature Communications
  • Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics, 2023, Proceedings of the National Academy of Sciences
  • Mild mitochondrial impairment enhances innate immunity and longevity through ATFS-1 and p38 signaling, 2021, EMBO Reports
  • An antisteatosis response regulated by oleic acid through lipid droplet-mediated ERAD enhancement, 2023, Science Advances

Frequent co-authors with whom T. Keith Blackwell has collaborated include Ziyun Wu, Meng Jin, Monet S. Bland, Juliane C. Campos, and Takafumi Ogawa. The scientist's publications have appeared predominantly in venues such as bioRxiv, Nature Communications, Proceedings of the National Academy of Sciences, EMBO Reports, and Science Advances.

The accumulation of publications in these venues reflects a sustained engagement with cutting-edge research in molecular biology and related life sciences areas, particularly focusing on mechanisms underlying aging, stress response, and metabolic function.

Best Publications

  • The myoD gene family: nodal point during specification of the muscle cell lineage

    Harold Weintraub;Robert Davis;Stephen Tapscott;Matthew Thayer

  • Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

    Jennifer M. A. Tullet;Maren Hertweck;Jae Hyung An;Jae Hyung An;Joseph Baker

  • Ordered rearrangement of immunoglobulin heavy chain variable region segments.

    F W Alt;G D Yancopoulos;T K Blackwell;C Wood

  • A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span

    Maria K. Lehtinen;Zengqiang Yuan;Peter R. Boag;Peter R. Boag;Yue Yang

  • Development of the primary antibody repertoire.

    FW Alt;TK Blackwell;GD Yancopoulos

  • SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response

    Jae Hyung An;T. Keith Blackwell

  • TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

    Stacey Robida-Stubbs;Kira Glover-Cutter;Dudley W. Lamming;Dudley W. Lamming;Masaki Mizunuma;Masaki Mizunuma

  • MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

    Georg Stoecklin;Tiffany Stubbs;Nancy Kedersha;Stephen Wax

  • SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.

    T. Keith Blackwell;T. Keith Blackwell;Michael J. Steinbaugh;John M. Hourihan;Collin Y. Ewald

  • Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

    George D. Yancopoulos;T.Keith Blackwell;Heikyung Suh;Leroy Hood

  • The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.

    Hideki Inoue;Naoki Hisamoto;Jae Hyung An;Riva P. Oliveira

  • Condition‐adapted stress and longevity gene regulation by Caenorhabditis elegans SKN‐1/Nrf

    Riva de Paula Oliveira;Jess Porter Abate;Kieran Dilks;Jessica Landis

  • The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

    Barbara A. Malynn;Barbara A. Malynn;T.Keith Blackwell;Gabrielle M. Fulop;Gary A. Rathbun;Gary A. Rathbun

  • A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

    Henri Marc Bourbon;Andres Aguilera;Aseem Z. Ansari;Francisco J. Asturias

  • Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

    Collin Y. Ewald;Collin Y. Ewald;Jess N. Landis;Jess Porter Abate;Jess Porter Abate;Coleen T. Murphy

  • CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo

    Eun Yong Shim;Amy K. Walker;Yang Shi;T. Keith Blackwell

  • Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity

    Marcelo A. Mori;Prashant Raghavan;Thomas Thomou;Thomas Thomou;Jeremie Boucher

  • Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3

    Jae Hyung An;Kelly Vranas;Michael Lucke;Hideki Inoue

  • Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.

    F Young;B Ardman;Y Shinkai;R Lansford

  • Supplemental Information TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

    Stacey Robida-Stubbs;Kira Glover-Cutter;Dudley W. Lamming;Masaki Mizunuma

Frequent Co-Authors

Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
George D. Yancopoulos
George D. Yancopoulos Regeneron (United States)
Yang Shi
Yang Shi University of Oxford
Dudley W. Lamming
Dudley W. Lamming University of Wisconsin–Madison
Kunihiro Matsumoto
Kunihiro Matsumoto Nagoya University
Coleen T. Murphy
Coleen T. Murphy Princeton University
Min Han
Min Han University of Colorado Boulder
David A. Sinclair
David A. Sinclair Harvard University
Robert A. Phillips
Robert A. Phillips University of Toronto

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