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Molecular Biology

D-Index
100
Citations
32104
World Ranking
538
National Ranking
295

Overview

Perry J. Blackshear is affiliated with the National Institutes of Health in the United States and has a substantial body of research primarily in the fields of Biochemistry, Genetics, and Molecular Biology as well as Medicine. Their work spans across several subfields including Molecular Biology, Immunology, Cancer Research, Physiology, and Epidemiology.

The research topics they have focused on include:

  • RNA Research and Splicing
  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • RNA and protein synthesis mechanisms
  • Immune Cell Function and Interaction
  • Immune Response and Inflammation
  • RNA regulation and disease

Their recent publications reflect these key areas of study. Selected papers include:

  • "The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses," 2022, Science Immunology
  • "Clinical implications of tristetraprolin (TTP) modulation in the treatment of inflammatory diseases," 2022, Pharmacology & Therapeutics
  • "Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice," 2020, Redox Biology
  • "Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice," 2020, Frontiers in Immunology
  • "Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy," 2020, Cellular and Molecular Gastroenterology and Hepatology

Frequent publication venues for Blackshear's work include:

  • Frontiers in Immunology
  • UNC Libraries
  • The Journal of Immunology
  • Cellular and Molecular Gastroenterology and Hepatology
  • The FASEB Journal

They have also collaborated frequently with several colleagues, including:

  • Deborah J. Stumpo
  • Wi S. Lai
  • Melissa E. Cook
  • Tara R. Bradstreet
  • Ashlee M. Webber

Best Publications

  • Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

    Ester Carballo;Wi S. Lai;Perry J. Blackshear

  • Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

    Wi S. Lai;Ester Carballo;Julie R. Strum;Elizabeth A. Kennington

  • A pathogenetic role for TNFα in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency

    Gregory A Taylor;Ester Carballo;David M Lee;Wi S Lai

  • The MARCKS family of cellular protein kinase C substrates.

    P J Blackshear

  • Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability.

    Ester Carballo;Wi S. Lai;Perry J. Blackshear

  • Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover.

    P. J. Blackshear;P. J. Blackshear

  • Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.

    Edward Hitti;Tatiana Iakovleva;Matthew Brook;Stefanie Deppenmeier

  • Interactions of CCCH Zinc Finger Proteins with mRNA BINDING OF TRISTETRAPROLIN-RELATED ZINC FINGER PROTEINS TO AU-RICH ELEMENTS AND DESTABILIZATION OF mRNA

    Wi S. Lai;Ester Carballo;Judith M. Thorn;Elizabeth A. Kennington

  • Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

    Matthew A. Coelho;Sophie de Carné Trécesson;Sareena Rana;Davide Zecchin

  • Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action.

    Seth A. Brooks;Perry J. Blackshear;Perry J. Blackshear

  • Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

    P J Blackshear;L A Witters;P R Girard;J F Kuo

  • Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C.

    Deborah J. Stumpo;Jonathan M. Graff;Katherine A. Albert;Paul Greengard

  • MARCKS deficiency in mice leads to abnormal brain development and perinatal death

    Deborah J. Stumpo;Cheryl B. Bock;Jane S. Tuttle;Perry J. Blackshear

  • Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ

    Matthew K. Topham;Michaeline Bunting;Guy A. Zimmerman;Thomas M. McIntyre

  • Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease.

    Wi S. Lai;Elizabeth A. Kennington;Perry J. Blackshear

  • Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein.

    W S Lai;D J Stumpo;P J Blackshear

  • Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C.

    J M Graff;T N Young;J D Johnson;P J Blackshear;P J Blackshear

  • Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology

    Dimitris Kontoyiannis;Alexey Kotlyarov;Ester Carballo;Lena Alexopoulou

  • RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins

    Mingui Fu;Perry J. Blackshear

  • Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs.

    Wi S. Lai;Elizabeth A. Kennington;Perry J. Blackshear

Frequent Co-Authors

Darryl C. Zeldin
Darryl C. Zeldin National Institutes of Health
Gregory A. Taylor
Gregory A. Taylor Duke University
Matthias Gaestel
Matthias Gaestel Hannover Medical School
Lalith Perera
Lalith Perera National Institutes of Health
Angus C. Nairn
Angus C. Nairn Yale University
Stanislas Goriely
Stanislas Goriely Université Libre de Bruxelles
Alfred M. Cohen
Alfred M. Cohen Cancer Prevention Pharmaceuticals (United States)
Roberta Faccio
Roberta Faccio Washington University in St. Louis
Roger L. Eddy
Roger L. Eddy Roswell Park Cancer Institute
Aviv Regev
Aviv Regev Genentech

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